Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicole Taub"'
Autor:
Barbara Scherz, Roland Rabl, Stefanie Flunkert, Siegfried Rohler, Joerg Neddens, Nicole Taub, Magdalena Temmel, Ute Panzenboeck, Vera Niederkofler, Robert Zimmermann, Birgit Hutter-Paier
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197674 (2018)
Transgenic mouse models are indispensable tools to mimic human diseases and analyze the effectiveness of related new drugs. For a long time amyotrophic lateral sclerosis (ALS) research depended on only a few mouse models that exhibit a very strong an
Externí odkaz:
https://doaj.org/article/47f096b395ef46148adcfa7f08e8eb0d
Autor:
Irene Sola, Elisabet Viayna, Tània Gómez, Carles Galdeano, Matteo Cassina, Pelayo Camps, Margherita Romeo, Luisa Diomede, Mario Salmona, Pilar Franco, Mireille Schaeffer, Diego Colantuono, David Robin, Daniela Brunner, Nicole Taub, Birgit Hutter-Paier, Diego Muñoz-Torrero
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 4492-4515 (2015)
We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer’s disease (AD). Its synthesis featur
Externí odkaz:
https://doaj.org/article/07c01f55a50348b5a7e8cec7faab37ec
Autor:
Luisa Diomede, Pilar Franco, Nicole Taub, Margherita Romeo, Pelayo Camps, Mario Salmona, Elisabet Viayna, David Robin, Birgit Hutter-Paier, Matteo Cassina, Carles Galdeano, Irene Sola, Diego Muñoz-Torrero, Mireille Schaeffer, Diego Colantuono, Tània Gómez, Daniela Brunner
Publikováno v:
Molecules
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Volume 20
Issue 3
Pages 4492-4515
Molecules, Vol 20, Iss 3, Pp 4492-4515 (2015)
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Volume 20
Issue 3
Pages 4492-4515
Molecules, Vol 20, Iss 3, Pp 4492-4515 (2015)
We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer’s disease (AD). Its synthesis featur
Autor:
Birgit Hutter-Paier, Meritxell Aguilo, Stefanie Flunkert, Nicole Taub, Joerg Neddens, Balázs Dobrovich, Robert Zimmermann
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Nicole Taub, Roland Rabl, Joerg Neddens, Stefanie Flunkert, Vera Niederkofler, Birgit Hutter-Paier, Barbara Scherz, Siegfried Rohler, Robert Zimmermann, Magdalena Temmel, Ute Panzenboeck
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197674 (2018)
PLoS ONE, Vol 13, Iss 5, p e0197674 (2018)
Transgenic mouse models are indispensable tools to mimic human diseases and analyze the effectiveness of related new drugs. For a long time amyotrophic lateral sclerosis (ALS) research depended on only a few mouse models that exhibit a very strong an
Autor:
Leopold Kremser, Beatrix Fürst, Taras Stasyk, Herbert Lindner, Michael W. Hess, Sabine Weys, Lukas A. Huber, Mariana E. G. de Araujo, Hannes L. Ebner, Przemyslaw A. Filipek, Nicole Taub
Publikováno v:
Journal of Biological Chemistry. 288:18228-18242
LAMTOR3 (MP1) and LAMTOR2 (p14) form a heterodimer as part of the larger Ragulator complex that is required for MAPK and mTOR1 signaling from late endosomes/lysosomes. Here, we show that loss of LAMTOR2 (p14) results in an unstable cytosolic monomeri
Autor:
Nicole Taub, Birgit Hutter-Paier, Joerg Neddens, Vera Niederkofler, Robert Zimmermann, Meritxell Aguilo, Ewald Auer
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
George C.T. Yeoh, Nicole Taub, Christine Bäuerl, Elisabeth Nimmerfall, Johannes Wieser, Pia-Maria Blaas, Ken M. Ng, Verena Puxbaum, Lukas Mach, Mario Mikula, Wolfgang Mikulits
Publikováno v:
Journal of Hepatology
Background & Aims The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R), a multifunctional protein, plays a central role in intracellular targeting of lysosomal enzymes and control of insulin-like growth factor II (IGF-II) bioact
Autor:
Nicole Taub, Manfred Windisch, Birgit Hutter-Paier, Stefanie Flunkert, Tina Löffler, Emma Schofield, Malcolm Ward
Publikováno v:
Journal of Molecular Neuroscience
The role of hyperphosphorylation of the microtubule-associated protein tau in the pathological processes of several neurodegenerative diseases is becoming better understood. Consequently, development of new compounds capable of preventing tau hyperph
Autor:
Lukas A. Huber, Ad J. M. Gillis, Marleen Blom, Hans Stoop, A. Koen Braat, Joseph H.A. Vissers, Marko Potman, Wouter Nijkamp, E. Verhoeven, Maarten van Lohuizen, Roderick L. Beijersbergen, Nicole Taub, Bart A. Westerman, Leendert H. J. Looijenga, Arno Velds
Publikováno v:
Journal of experimental medicine, 208(13), 2675-2689. Rockefeller University Press
The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2675-2689. Rockefeller University Press
Westerman, B A, Braat, A K, Taub, N, Potman, M, Vissers, J H A, Blom, M, Verhoeven, E, Stoop, H, Gillis, A, Velds, A, Nijkamp, W, Beijersbergen, R, Huber, L A, Looijenga, L H J & van Lohuizen, M 2011, ' A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation ', Journal of Experimental Medicine, vol. 208, no. 13, pp. 2675-2689 . https://doi.org/10.1084/jem.20102037
The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2675-2689. Rockefeller University Press
Westerman, B A, Braat, A K, Taub, N, Potman, M, Vissers, J H A, Blom, M, Verhoeven, E, Stoop, H, Gillis, A, Velds, A, Nijkamp, W, Beijersbergen, R, Huber, L A, Looijenga, L H J & van Lohuizen, M 2011, ' A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation ', Journal of Experimental Medicine, vol. 208, no. 13, pp. 2675-2689 . https://doi.org/10.1084/jem.20102037
Knockdown of the scaffolding protein Mek binding protein 1 (Mp1) in mouse embryonic stem cells suppresses differentiation but not proliferation, and more invasive human germ cell tumors express lower amounts of Mp1.
Despite intense investigation
Despite intense investigation