Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nicole T. Watt"'
Autor:
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36457- (2024)
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor. Whether this reflects the failure to simult
Externí odkaz:
https://doaj.org/article/8e31cd24581c4d399766217804bdc0d5
Autor:
Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activatio
Externí odkaz:
https://doaj.org/article/e431ba3360bc41d78c30c04a825835be
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and in disease. Zinc is released into the synaptic cleft of glutamatergic neurons alongside glutamate from where it interacts and modulates NMDA and AMPA recepto
Externí odkaz:
https://doaj.org/article/a3f6a89c92924a939b175cd7ba96443c
Autor:
Helen Imrie, Hema Viswambharan, Natalie J Haywood, Katherine I Bridge, Nadira Y Yuldasheva, Stacey Galloway, Katie J Simmons, Richard M Cubbon, Piruthivi Sukumar, Nicole T Watt, Laeticia Lichtenstein, Judy I Wyatt, Hiromi Kudo, Robert Goldin, Baptiste Rode, Stephen B Wheatcroft, Mark T Kearney
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 366-378 (2022)
High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting in deposition of lipids in tissues ill-equipped to deal with this challenge. The role of insulin like growth factor-1 (IGF-1) in
Externí odkaz:
https://doaj.org/article/3a306229dac84d0493dc86af288e28b8
Publikováno v:
BioEssays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6472e9fcbe5d9e9798e5fc1ce553538e
https://doi.org/10.1002/bies.202300029
https://doi.org/10.1002/bies.202300029
Autor:
Hélène N Daou, Nicole T Watt, Amanda DV MacCannell, Mattia Scalabrin, Shaimaa Gad, Simon Futers, David J Beech, Scott T Bowen, Lee D Roberts
Publikováno v:
Physiology. 38
Skeletal muscle integrates many of the systemic signals, which contribute to the adaptive remodeling, and beneficial effects of exercise. One mechanism through which muscle mediates the systemic effects of exercise is through muscle-derived hormones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4d3c9e75ed020804f4037e6c99af43
https://doi.org/10.1152/physiol.2023.38.s1.5786418
https://doi.org/10.1152/physiol.2023.38.s1.5786418
Autor:
Hannah A. Taylor, Katie J. Simmons, Eva M. Clavane, Christopher J. Trevelyan, Jane M. Brown, Lena Przemyłska, Nicole T. Watt, Laura C. Matthews, Paul J. Meakin
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4568
The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is an extensively studied therapeutic target for Alzheimer’s disease (AD), owing to its role in the production of neurotoxic amyloid beta (Aβ) peptides. However, despite numerous BACE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600584819b99fb9da8848ef1c29f1105
https://pubmed.ncbi.nlm.nih.gov/35562959
https://pubmed.ncbi.nlm.nih.gov/35562959
Autor:
Stephen B. Wheatcroft, Andrew Walker, Anna Skromna, Piruthivi Sukumar, Amy Moron, Chloe G Wilkinson, Antonio Vidal-Puig, Natallia Makava, Mark T. Kearney, Michael Drozd, Katherine I Bridge, Cheukyau Luk, Jason L. Scragg, Nicole T. Watt, Hema Viswambharan, Lee D. Roberts, Kathryn J. Griffin, Nadira Yuldasheva, Katie J. Simmons, Jessica Smith, Nele Warmke, Romana Mughal, Richard M Cubbon, Klaus K. Witte, Sunti Limumpornpetch, Claire H Ozber, Sam Straw, Natalie J Haywood, David J. Beech
SummaryThere are at least two distinct types of thermogenic adipocyte in mammals: a pre-existing form established during development, termed classical brown adipocytes and an inducible form, ‘beige’ adipocytes1–3. Various environmental cues can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f706df9edc76eca7ebe2a29b6496567e
https://doi.org/10.1101/2021.12.01.470734
https://doi.org/10.1101/2021.12.01.470734
Autor:
Mark T. Kearney, Jürgen E. Schneider, Michael Drozd, Nadira Yuldasheva, Amanda D. V. MacCannell, Lee D. Roberts, Jordan H. Boyle, Natallia Makava, Sean Smart, Stephen B. Wheatcroft, Richard M Cubbon, Anna Skromna, Chloe G Wilkinson, Katherine I Bridge, Claire H Ozber, David J. Beech, Irvin Teh, Piruthivi Sukumar, Natalie J Haywood, Joanna Koch-Paszkowski, Cheukyau Luk, Nicole T. Watt, Nele Warmke
Publikováno v:
EMBO Rep
Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin-like growth factor-1 (IGF-1) and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110b96a75b23e3b0156d72d9ea5d2384
https://doi.org/10.15252/embr.202050767
https://doi.org/10.15252/embr.202050767
Autor:
Ben Mercer, Romana Mughal, Peter Carmeliet, Mark T. Kearney, Kathryn J. Griffin, Nadira Yuldasheva, Stacey Galloway, Natalie J Haywood, Taha Soomro, Stephen B. Wheatcroft, Nicole T. Watt, Richard M Cubbon, Jessica Smith, Nele Warmke, Andrew Walker, David J. Beech
Publikováno v:
Endocrinology
Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr+/-) against littermate controls, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00726d150fa618f7a840ea23986162a
https://pubmed.ncbi.nlm.nih.gov/34037749
https://pubmed.ncbi.nlm.nih.gov/34037749