Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicole St-Denis"'
Autor:
Idil Ulengin-Talkish, Matthew A. H. Parson, Meredith L. Jenkins, Jagoree Roy, Alexis Z. L. Shih, Nicole St-Denis, Gergo Gulyas, Tamas Balla, Anne-Claude Gingras, Péter Várnai, Elizabeth Conibear, John E. Burke, Martha S. Cyert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Calcineurin — the Ca2+ regulated phosphatase and target of immunosuppressants — regulates GPCR-mediated phospholipid signaling at the plasma membrane. Here the authors show that CNAβ1 (a poorly studied isoform of the calcineurin catalytic subuni
Externí odkaz:
https://doaj.org/article/3b894a2338db4ca0a402fda3dfce006b
Autor:
Elizabeth Conibear, Tamas Balla, Péter Várnai, Meredith L. Jenkins, Anne-Claude Gingras, Matthew A.H. Parson, Nicole St-Denis, John E. Burke, Idil Ulengin-Talkish, Gergo Gulyas, Alexis Z. L. Shih, Martha S. Cyert, Jagoree Roy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a critical mediator of Ca2+ signaling. Here, to discover calcineurin-regulated processes we examined an understudied isoform, CNAβ1. We show that unlike canonical cy
Autor:
Anne-Claude Gingras, Jalal M. Kazan, Hyeonju Jeong, Arnim Pause, Pirjo M. Apaja, Gergely L. Lukacs, Nicole St. Denis, Ariel Roldan, Claire E. Martin, Guillaume Desrochers, Dmitri Kharitidi
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103274-(2021)
iScience, Vol 24, Iss 11, Pp 103274-(2021)
Summary Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms comple
Publikováno v:
Mol Cell Biol
Proper mitotic progression is crucial for maintenance of genomic integrity in proliferating cells and is regulated through an intricate series of events, including protein phosphorylation governed by a complex network of protein kinases. One kinase f
Autor:
Jagoree Roy, John E. Burke, Alexis Z. L. Shih, Anne-Claude Gingras, Péter Várnai, Nicole St-Denis, Gergo Gulyas, Meredith L. Jenkins, Tamas Balla, Elizabeth Conibear, Martha S. Cyert, Matthew A.H. Parson, Idil Ulengin-Talkish
Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a critical mediator of Ca2+ signaling. To discover novel calcineurin-regulated processes we examined an understudied isoform, CNAβ1. We show that unlike canonical cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6bff6339c4327f4a491d03cb31fd38
https://doi.org/10.1101/2021.07.14.451536
https://doi.org/10.1101/2021.07.14.451536
Autor:
Annabel Villedieu, Katelyn D. Darowski, Hongbo Guo, Anne-Claude Gingras, Caterina Iorio, Nicole St-Denis, Igor Stagljar, Zhong Yao, Ramy H. Malty, Andrew Emili, Victoria Wong, Benjamin G. Neel, Hiroyuki Aoki, Max Kotlyar, Yang Xu, Shahreen Amin, Igor Jurisica, Fabian Offensperger, Mohan Babu
Publikováno v:
Molecular Cell. 65:347-360
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the Membrane Yeast Two-Hybrid (MYTH) and the Mammalian Membrane T
Autor:
Elizabeth Conibear, Martha S. Cyert, Anne-Claude Gingras, Nicole St-Denis, Alexis Z. L. Shih, Rachel Bond, Tamas Balla, Péter Várnai, Idil Ulengin-Talkish
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Anne-Claude Gingras, Gagan D. Gupta, Nicole St-Denis, Zhen Yuan Lin, Laurence Pelletier, Beatriz Gonzalez-Badillo
Publikováno v:
Molecular & Cellular Proteomics. 14:946-960
The myotubularins are a family of phosphatases that dephosphorylate the phosphatidylinositols phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-phosphate. Several family members are mutated in disease, yet the biological functions of the
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators
Autor:
Gagan D. Gupta, Johnny M. Tkach, Laurence Pelletier, Zhen Yuan Lin, Amanda O. Veri, Dushyandi Rajendran, Ko W. Currie, Amber L. Couzens, Anne-Claude Gingras, Beatriz Gonzalez-Badillo, Sally W.T. Cheung, James D.R. Knight, Nicole St-Denis
Publikováno v:
Cell reports. 17(9)
SummaryReversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied
Publikováno v:
Journal of Cell Science. 124:2341-2348
CK2 is a serine/threonine kinase with many substrates, largely unknown modes of regulation and essential roles in mitotic progression. CK2α, a catalytic subunit of CK2, is phosphorylated in mitosis, and here we examine the effect of phosphorylation