Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicole Sgambellone"'
Autor:
Jocelyn Rivera, Xiaoying Xu, Haengsoon Park, Lesley Schultz, Kamil Paruch, David A. Parry, Alvarez Carmen S, Emma Lees, Thierry O. Fischmann, Doll Ronald J, Tara M. Stauffer, Laura R. Rokosz, Chad E. Knutson, Wolfgang Seghezzi, Vincent S. Madison, Alan Hruza, Michael P. Dwyer, Ray Anthony James, Derek Wiswell, Mckittrick Brian A, Greg Tucker, Frances Shanahan, Nicole Sgambellone, Kerry Keertikar, Randall R. Rossman, Timothy J. Guzi, Vidyadhar M. Paradkar, Yaolin Wang, Quiao Zhou, Paul Kirschmeier, Amin A. Nomeir, Tin-Yau Chan, Courtney Brown
Publikováno v:
ACS Medicinal Chemistry Letters. 1:204-208
Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development of novel oncology therapeutics. Herein is described the utilization of an in vivo screening approach with integrated efficacy and tolerability par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7390edd40f7ca65dc0aeccd13f3ca9
https://doi.org/10.1021/ml100051d
https://doi.org/10.1021/ml100051d
Autor:
Nicole Sgambellone, Chi-Chao Chan, Yoichiro Iwakura, Daniel J. Cua, Phyllis B. Silver, Dror Luger, Jun Tang, Zoe Chen, Rachel R. Caspi, Edward P. Bowman
Publikováno v:
The Journal of Experimental Medicine
Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We examined the role of the interleukin (IL)-23–IL-17 and IL-12–T helper cell (Th)1 pathways in the pathogenesis of EAU. IL–23 but not IL-12 was necessary to elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960b0e723de6f93b7ee5520df0acaaa
http://europepmc.org/articles/PMC2292220
http://europepmc.org/articles/PMC2292220
Autor:
Kamil Paruch, Jose S. Duca, Wolfgang Seghezzi, David A. Parry, Frances Shanahan, Kerry Keertikar, Emma Lees, Carmen S. Alvarez, Doll Ronald J, Timothy J. Guzi, Thierry O. Fischmann, Michael P. Dwyer, Alan Hruza, Nicole Sgambellone, Derek Wiswell, Vincent Madison
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fb0ddeade0a1d1047966807e775062
https://pubmed.ncbi.nlm.nih.gov/17904366
https://pubmed.ncbi.nlm.nih.gov/17904366
Autor:
Daniel J. Cua, Jun Tang, Edward P. Bowman, Rachel R. Caspi, Nicole Sgambellone, Yoichiro Iwakura, Chi-Chao Chan, Phyllis B. Silver, Dror Luger, Zoe Chen
Publikováno v:
Cytokine. 39:26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f785de7ed0502c3b9a77f95ffa7fe0b
https://doi.org/10.1016/j.cyto.2007.07.098
https://doi.org/10.1016/j.cyto.2007.07.098