Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Nicole S. Spoelstra"'
Autor:
Anthony D. Elias, Nicole S. Spoelstra, Alyse W. Staley, Sharon Sams, Lyndsey S. Crump, Gregory A. Vidal, Virginia F. Borges, Peter Kabos, Jennifer R. Diamond, Elena Shagisultanova, Anosheh Afghahi, Jose Mayordomo, Tessa McSpadden, Gloria Crawford, Angelo D’Alessandro, Kathryn L. Zolman, Adrie van Bokhoven, Yonghua Zhuang, Rosa I. Gallagher, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Dexiang Gao, Jennifer K. Richer
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract This clinical trial combined fulvestrant with the anti-androgen enzalutamide in women with metastatic ER+/HER2− breast cancer (BC). Eligible patients were women with ECOG 0–2, ER+/HER2− measurable or evaluable metastatic BC. Prior fulv
Externí odkaz:
https://doaj.org/article/ad0c82b5d82a4e81a6170a0a923d1435
Autor:
Zheqi Li, Nicole S. Spoelstra, Matthew J. Sikora, Sharon B. Sams, Anthony Elias, Jennifer K. Richer, Adrian V. Lee, Steffi Oesterreich
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Both TP53 and ESR1 mutations occur frequently in estrogen receptor positive (ER+) metastatic breast cancers (MBC) and their distinct roles in breast cancer tumorigenesis and progression are well appreciated. Recent clinical studies discovere
Externí odkaz:
https://doaj.org/article/03cb6e6b73364a1baa4c00765d7de9ff
Autor:
Toru Hanamura, Jessica L. Christenson, Kathleen I. O’Neill, Emmanuel Rosas, Nicole S. Spoelstra, Michelle M. Williams, Jennifer K. Richer
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Purpose Accumulating evidence has attracted attention to the androgen receptor (AR) as a biomarker and therapeutic target in breast cancer. We hypothesized that AR activity within the tumor has clinical implications and investigated whether
Externí odkaz:
https://doaj.org/article/0371be8231394e019312e132cfe5dbce
Autor:
Michelle M. Williams, Jessica L. Christenson, Kathleen I. O’Neill, Sabrina A. Hafeez, Claire L. Ihle, Nicole S. Spoelstra, Jill E. Slansky, Jennifer K. Richer
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Many immune suppressive mechanisms utilized by triple negative breast cancer (TNBC) are regulated by oncogenic epithelial-to-mesenchymal transition (EMT). How TNBC EMT impacts innate immune cells is not fully understood. To determine how TNB
Externí odkaz:
https://doaj.org/article/60e89acc1885465fafd6cd0d4bea2bf5
Autor:
Natalia B. Fernández, Sofía M. Sosa, Justin T. Roberts, María S. Recouvreux, Luciana Rocha-Viegas, Jessica L. Christenson, Nicole S. Spoelstra, Facundo L. Couto, Ana R. Raimondi, Jennifer K. Richer, Natalia Rubinstein
Publikováno v:
Cells, Vol 12, Iss 3, p 444 (2023)
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no effective targeted therapies are available. Growing evidence suggests that chemotherapy-resistant cancer cells with stem-like properties (CSC) may repopulate the
Externí odkaz:
https://doaj.org/article/82ee5a10864e493fb5f423a04c49e88e
Autor:
Kathleen I. O’Neill, Li-Wei Kuo, Michelle M. Williams, Hanne Lind, Lyndsey S. Crump, Nia G. Hammond, Nicole S. Spoelstra, M. Cecilia Caino, Jennifer K. Richer
Publikováno v:
Cancers, Vol 14, Iss 14, p 3543 (2022)
Triple-negative breast cancer (TNBC) often undergoes at least partial epithelial-to-mesenchymal transition (EMT) to facilitate metastasis. Identifying EMT-associated characteristics can reveal novel dependencies that may serve as therapeutic vulnerab
Externí odkaz:
https://doaj.org/article/773f4b7fb82749dbb78c461246ac43e8
Autor:
Jennifer K. Richer, Joel R. Eisner, Anthony Elias, Elaina T. Van Patten, Jordan Reese, G. Devon Trahan, Kenneth L. Jones, Nicole S. Spoelstra, Michelle M. Williams, Kathleen I. O'Neill, Jessica L. Christenson
Single-cell RNAseq of AR expressing MDA-MB-453 TNBC cells. scRNAseq was performed on untreated MDA-MB-453 cells cultured in full serum media. Cells were divided in groups based on their expression of AR, ARLow and ARHigh. (A) tSNE plot of AR levels i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbf37a51d74bc33ff7d21665e1ab4ca
https://doi.org/10.1158/1535-7163.22522315.v1
https://doi.org/10.1158/1535-7163.22522315.v1
Autor:
Jennifer K. Richer, Britta M. Jacobsen, Jason Gertz, Anthony Elias, Carol A. Sartorius, Thomas J. Rogers, Valerie N. Barton, Vernon T. Phan, Kathleen C. Torkko, Kiel T. Carson Butterfield, Nicole S. Spoelstra, Beatrice Babbs, Michael A. Gordon, Nicholas C. D'Amato
S1. Enza or AR knockdown decrease baseline and E2-induced proliferation of breast cancer cells in vitro. S2. E2 induces and Enza inhibits AR nuclear localization. S3. AR and ER binding in MCF7 cells. S4. Enza synergizes with anti-estrogens. S5. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ebfa7a4bf9b6c98a3fee34d571b345
https://doi.org/10.1158/1541-7786.22514868.v1
https://doi.org/10.1158/1541-7786.22514868.v1
Autor:
Jennifer K. Richer, Britta M. Jacobsen, Jason Gertz, Anthony Elias, Carol A. Sartorius, Thomas J. Rogers, Valerie N. Barton, Vernon T. Phan, Kathleen C. Torkko, Kiel T. Carson Butterfield, Nicole S. Spoelstra, Beatrice Babbs, Michael A. Gordon, Nicholas C. D'Amato
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e04739f44a5cdc804986faf0a40dc15
https://doi.org/10.1158/1541-7786.22514865
https://doi.org/10.1158/1541-7786.22514865
Autor:
Jennifer K. Richer, Joel R. Eisner, Anthony Elias, Elaina T. Van Patten, Jordan Reese, G. Devon Trahan, Kenneth L. Jones, Nicole S. Spoelstra, Michelle M. Williams, Kathleen I. O'Neill, Jessica L. Christenson
Gene expression changes following DHT treatment in HCI-009 PDXs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c53a70a81f9c0d97a096182a3c60a86
https://doi.org/10.1158/1535-7163.22522306.v1
https://doi.org/10.1158/1535-7163.22522306.v1