The mechanical influence of densification on epithelial architecture.

Autor: Christian Cammarota, Nicole S Dawney, Philip M Bellomio, Maren Jüng, Alexander G Fletcher, Tara M Finegan, Dan T Bergstralh

Publikováno v: PLoS Computational Biology, Vol 20, Iss 4, p e1012001 (2024)

Epithelial tissues are the most abundant tissue type in animals, lining body cavities and generating compartment barriers. The function of a monolayered epithelial tissue-whether protective, secretory, absorptive, or filtrative-relies on the side-by-

Externí odkaz: https://doaj.org/article/c4e1ec2af1c44925ac01768b342d6c4e

Competition Between Cell-Cell and Cell-Substrate Adhesion Determines Epithelial Monolayer Architecture in Culture

Autor: Philip M Bellomio, Alexander G. Fletcher, Maren M Jung, Qingyuan Jia, Daniel T. Bergstralh, Joseph A Glichowski, Christian M. Cammarota, Nicole S Dawney

SummaryOrgan surfaces are lined by epithelial monolayers - sheets of cells that are one-cell thick. This architecture underlies tissue function, and its loss is associated with disease, including cancer. Studies of in-plane epithelial cell behaviors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce0b3bea205cc0c5c844c4ec50574395
https://doi.org/10.1101/2021.09.13.460154

Tissue tension and not interphase cell shape determines cell division orientation in the

Autor: Tara M, Finegan, Daxiang, Na, Christian, Cammarota, Austin V, Skeeters, Tamás J, Nádasi, Nicole S, Dawney, Alexander G, Fletcher, Patrick W, Oakes, Dan T, Bergstralh

Publikováno v: The EMBO journal. 38(3)

The shapes and architecture of the organs in the animal body develop through complex coordination of cell shape change, cell migration, and cell proliferation. Finegan et al (2019) use the simple model of the Drosophila ovary and elongation of each e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::908a7d36fba8fd1bb432a73b76839305
https://pubmed.ncbi.nlm.nih.gov/30679198

Pins is not required for spindle orientation in the Drosophila wing disc

Autor: Nicole S Dawney, Holly E. Lovegrove, Daniel St Johnston, Izabela Kujawiak, Jinwei Zhu, Daniel T. Bergstralh, Rongguang Zhang, Samantha Cooper

Publikováno v: Bergstralh, D T, Lovegrove, H, Kujawiak, I, Dawney, N S, Zhu, J, Cooper, S, Zhang, R & Johnston, D S 2016, ' Pins is not required for spindle orientation in the drosophila wing disc ', Development (Cambridge), vol. 143, no. 14, pp. 2573-2581 . https://doi.org/10.1242/dev.135475
Development (Cambridge, England)

In animal cells, mitotic spindles are oriented by the dynein/dynactin motor complex, which exerts a pulling force on astral microtubules. Dynein/dynactin localization depends on Mud/NUMA, which is typically recruited to the cortex by Pins/LGN. In Dro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f91a740107de1195ef36b2093ccd014
https://doi.org/10.1242/dev.135475