Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicole R. Sullivan"'
Autor:
Gonzalo A. Carrasco, Deborah N. D'Souza, Nancy A. Muma, James W. Crane, Louis D. Van de Kar, Keiko Shimizu, Cuihong Jia, George Battaglia, Yahong Zhang, Francisca Garcia, Nicole R. Sullivan
Publikováno v:
Brain Research. 1183:51-59
Brain serotonin 1A (5-HT 1A ) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. We previously reported that systemic administration of either full or partial 5-HT 1A agonists increases neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c9a40093a064287a1f6288bec3cc79
https://doi.org/10.1016/j.brainres.2007.07.101
https://doi.org/10.1016/j.brainres.2007.07.101
Autor:
William Adams, Terri Cummons, Adedayo Adedoyin, Valerie Smith, Nicole R. Sullivan, Liza Leventhal, Taylor Spangler, Garth Whiteside, Shaiu-Ching Sun, Albert J. Uveges, James H. Harrison, Jonathan Schantz, Brian W. Strassle, Alena Barry, Rana Ramdass, Peimin Lu, Philip G. Jones, Michael J. Piesla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:1294-1304
Here, we have investigated the in vitro pharmacology of a muscarinic agonist, (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983), and we demonstrated its activity in several models of pain. WAY-132983 had a similar a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7102703eae594820ecea62286159f5d3
https://doi.org/10.1124/jpet.106.118604
https://doi.org/10.1124/jpet.106.118604
Autor:
Paige E. Mahaney, Puwen Zhang, Casey C. McComas, Eugene John Trybulski, Ani Sarkahian, Nicole R. Sullivan, Liza Leventhal, Albert J. Uveges, Lisa Nogle, William L. Watts, An T. Vu
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8455-8466
Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including major depressive disorder and pain disorders such as diabetic neuropathy and fibromyalgia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf20c6072374d9fa11c4b618abfe2fa
https://doi.org/10.1016/j.bmc.2006.08.039
https://doi.org/10.1016/j.bmc.2006.08.039
Autor:
Gonzalo A. Carrasco, L.D. Van de Kar, Nicole R. Sullivan, Michelle Landry, Francisca Garcia, George Battaglia, Nancy A. Muma
Publikováno v:
Neuroscience. 143:7-13
We previously reported that treatment and withdrawal from cocaine increases: (1) 5-HT 2A receptor-mediated neuroendocrine responses, and (2) Gα q and Gα 11 G-protein levels in the hypothalamic paraventricular nucleus (PVN) at 48 h post-treatment. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c172d645e440a8f66cc6111c59629a72
https://doi.org/10.1016/j.neuroscience.2006.09.021
https://doi.org/10.1016/j.neuroscience.2006.09.021
Autor:
Nicole R. Sullivan, Louis D. Van de Kar, Yijin She, Bozena Zemaitaitis, Kathleen H. Young, Nancy A. Muma, Gonzalo A. Carrasco, Francisca Garcia, Katerina J. Damjanoska, David Howland, George Battaglia, Ju Shi
Publikováno v:
Neuropharmacology. 51:524-535
Serotonin 2A (5-HT2A) receptors are coupled to Galphaq and Galpha11 proteins to activate phospholipase C (PLC). Regulators of G-protein signaling proteins (RGS) modulate G-protein signaling by accelerating the intrinsic GTPase activity of Galphaq and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f38f696694d8f5dcf5335c89f7df3e
https://doi.org/10.1016/j.neuropharm.2006.04.012
https://doi.org/10.1016/j.neuropharm.2006.04.012
Autor:
Francisca Garcia, Nicole R. Sullivan, Angela J. Grippo, Ju Shi, Katerina J. Damjanoska, Zhuo Chen, Gonzalo A. Carrasco, James W. Crane, Nancy A. Muma, Louis D. Van de Kar
Publikováno v:
Psychopharmacology. 179:769-780
Interactions among stress, serotonin 1A (5-HT(1A)) receptors, and the hypothalamic-pituitary-adrenocortical (HPA) system have been proposed to influence the development of depression in humans. The investigation of depression-relevant behaviors and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09b7ecc400e5dc900216532dd83f99a
https://doi.org/10.1007/s00213-004-2103-4
https://doi.org/10.1007/s00213-004-2103-4
Autor:
Deborah N. D'Souza, Katerina J. Damjanoska, S.A Barker, Francisca Garcia, L.D. Van de Kar, Nancy A. Muma, Nicole R. Sullivan, Gonzalo A. Carrasco, Yahong Zhang
Publikováno v:
Neuroscience. 127:261-267
Desensitization of post-synaptic serotonin 1A (5-HT 1A ) receptors may underlie the clinical improvement of neuropsychiatric disorders. In the hypothalamic paraventricular nucleus, Gα z proteins mediate the 5-HT 1A receptor-stimulated increases in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba5171135e32ddbbc1624324d86acb7
https://doi.org/10.1016/j.neuroscience.2004.05.031
https://doi.org/10.1016/j.neuroscience.2004.05.031
Autor:
Francisca Garcia, Yahong Zhang, George Battaglia, Gonzalo A. Carrasco, Nancy A. Muma, Katerina J. Damjanoska, Nicole R. Sullivan, Deborah N. D'Souza, Lydia L. DonCarlos, Louis D. Van de Kar
Publikováno v:
Neuroendocrinology. 80:31-41
The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT1A) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT1A receptor agonist (±)8-OH-DPAT (5, 15 or 30 min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d14c3fe5789f386159f2878ff16384
https://doi.org/10.1159/000080795
https://doi.org/10.1159/000080795
Autor:
Francisca Garcia, Nicole R. Sullivan Hanley, Deborah N. D'Souza, Louis D. Van de Kar, Julie E. Tetzlaff, George Battaglia, Nancy A. Muma, Bertalan Dudas, Brett R. Petersen, Katerina J. Damjanoska, Gonzalo A. Carrasco, Yahong Zhang, Kumar Scripathirathan, Thackery S. Gray
Publikováno v:
The Journal of Neuroscience. 22:9635-9642
The present study determined whether the serotonin(2A) (5-HT(2A)) receptors in the hypothalamic paraventricular nucleus mediate the neuroendocrine responses to a peripheral injection of the 5-HT(2A/2C)receptor agonist (−)DOI [(−)1-(2,5-dimethoxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3cd1da02b4286893872bfda5982610
https://doi.org/10.1523/jneurosci.22-21-09635.2002
https://doi.org/10.1523/jneurosci.22-21-09635.2002
Publikováno v:
Journal of Neurochemistry. 77:589-597
We have investigated in C6 glioma cells the involvement of protein kinase C (PKC) in the regulation of serotonin-(2A) receptor (5-HT(2A) receptor) expression by agonist treatment. Comparison of the time-courses of agonist-induced downregulation of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6356af8d3e0ce189f99093896cb69bce
https://doi.org/10.1046/j.1471-4159.2001.00261.x
https://doi.org/10.1046/j.1471-4159.2001.00261.x