Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicole R. Higdon"'
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058d11e4149544128cfd448da56d7569
https://doi.org/10.1016/j.bmc.2006.09.019
https://doi.org/10.1016/j.bmc.2006.09.019
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbbbb19eb89de61edd6e606a68da00
https://doi.org/10.1021/jm0602413
https://doi.org/10.1021/jm0602413
Autor:
Raymond S. Hurst, Vincent E. Groppi, Bruce N. Rogers, Alice L. Bodnar, Theron M. Wall, Luz A. Cortes-Burgos, Jason K. Myers, Dac M. Dinh, Nicole R. Higdon, Mark L. Wolfe, Erik H. F. Wong, Karen K. Cook, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 48:905-908
A library of benzamides was tested for alpha7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this library, quinuclidine benzamides were found to have alpha7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c869cd816f6b43ca88a5152d5473990d
https://doi.org/10.1021/jm049363q
https://doi.org/10.1021/jm049363q
Autor:
Vincent E. Groppi, Nicole R. Higdon, Raymond S. Hurst, Mihály Hajós, William E. Hoffmann, Michael Krause, Theron M. Wall
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:1213-1222
Schizophrenic patients are thought to have an impaired ability to process sensory information. This deficit leads to disrupted auditory gating measured electrophysiologically as a reduced suppression of the second of paired auditoryevoked responses (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fad24b44542ae4409e3f8e25429ee6
https://doi.org/10.1124/jpet.104.076968
https://doi.org/10.1124/jpet.104.076968
Autor:
Martin D. Meglasson, Michael A. Clark, Karen L. Rutherford-Root, Nicole R. Higdon, Judy A. Lawson, Raymond S. Hurst, William G. McDonald, Joseph V. Haas, James P. McGrath
Publikováno v:
European Journal of Pharmacology. 482:31-37
Four dopamine receptor agonists used for the treatment of Parkinson's disease (apomorphine, pergolide, ropinirole and sumanirole) were evaluated for the ability to block human ether-a-go-go related gene (hERG) K(+) channels and to modify the duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e233b6f7a3ea592994fd0d2002bbfb
https://doi.org/10.1016/j.ejphar.2003.09.054
https://doi.org/10.1016/j.ejphar.2003.09.054
Autor:
Sonia Bertrand, David W. Piotrowski, Vincent E. Groppi, Theron M. Wall, Mario Raggenbass, Raymond S. Hurst, Karen L. Rutherford-Root, Nicole R. Higdon, Mihály Hajós, R. Ogier, William E. Hoffmann, Mitchell B. Berkenpas, Daniel Bertrand, Stephen P. Arneric, Geraldine Allaman, Judy A. Lawson
Publikováno v:
Journal of Neuroscience, Vol. 25, No 17 (2005) pp. 4396-4405
Several lines of evidence suggest a link between the alpha7 neuronal nicotinic acetylcholine receptor (nAChR) and brain disorders including schizophrenia, Alzheimer's disease, and traumatic brain injury. The present work describes a novel molecule, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa11afca755e5e116ae17757f441993
https://europepmc.org/articles/PMC6725110/
https://europepmc.org/articles/PMC6725110/
Autor:
M. Clark, Jill A. Dalton, Nicole R. Higdon, Mark L. Wolfe, Theodore J. Baird, David V. Gauvin, Theron Wall
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:168-169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf5aac71ff8c2d794b56fd45c7372e5
https://doi.org/10.1016/j.vascn.2008.05.093
https://doi.org/10.1016/j.vascn.2008.05.093