Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicole Pribut"'
Autor:
Kiran S. Toti, Nicole Pribut, Michael D’Erasmo, Madhuri Dasari, Savita K. Sharma, Perry W. Bartsch, Samantha L. Burton, Hannah B. Gold, Anatoliy Bushnev, Cynthia A. Derdeyn, Adriaan E. Basson, Dennis C. Liotta, Eric J. Miller
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy.
Externí odkaz:
https://doaj.org/article/95897a2077a94f00b1666c0194367d18
Autor:
Madhuri Dasari, Stephen C. Pelly, Jiafeng Geng, Hannah B. Gold, Nicole Pribut, Savita K. Sharma, Michael P. D’Erasmo, Perry W. Bartsch, Carrie Sun, Kiran Toti, Rebecca S. Arnold, John A. Petros, Lingjie Xu, Yi Jiang, Eric J. Miller, Dennis C. Liotta
Publikováno v:
ACS Pharmacology & Translational Science. 6:702-709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae41ed73a3e6aa38dfae85c4e54699f4
https://doi.org/10.1021/acsptsci.2c00252
https://doi.org/10.1021/acsptsci.2c00252
Autor:
Anatoliy S. Bushnev, Perry W. Bartsch, Savita Sharma, Kyle E. Giesler, Dennis C. Liotta, Eric J. Miller, Madhuri Dasari, D'erasmo Michael, Adriaan E. Basson, Soyon S. Hwang, Akshay Raghuram, Nicole Pribut, Iskandar Sabrina, Samantha L. Burton, Cynthia A. Derdeyn
Publikováno v:
Journal of Medicinal Chemistry. 64:12917-12937
Tenofovir (TFV) is the cornerstone nucleotide reverse transcriptase inhibitor (NtRTI) in many combination antiretroviral therapies prescribed to patients living with HIV/AIDS. Due to poor cell permeability and oral bioavailability, TFV is administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fe8f64ae776888f4188d89e13f619a
https://doi.org/10.1021/acs.jmedchem.1c01083
https://doi.org/10.1021/acs.jmedchem.1c01083
Autor:
Perry W. Bartsch, Julien Sourimant, Thalia Le, Edgars Jecs, Nicole Pribut, Richard K. Plemper, Stephen C. Pelly, Robert Wilson, Zackery W. Dentmon, Savita Sharma, Pieter B. Burger, Jeong-Joong Yoon, Dennis C. Liotta, Thomas M. Kaiser, Soyon S. Hwang
Publikováno v:
ACS Infect Dis
A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound 2 in particular exhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cce3380433cbafe8e4064585046da3
https://doi.org/10.1021/acsinfecdis.9b00524
https://doi.org/10.1021/acsinfecdis.9b00524
Autor:
Nicole Pribut, Stephen C. Pelly, Adriaan E. Basson, Dennis C. Liotta, Willem A. L. van Otterlo
Publikováno v:
ACS medicinal chemistry letters. 10(2)
[Image: see text] Since the discovery of HIV as the etiological agent of AIDS, the virus has infected millions of people each year. Fortunately, with the use of HAART, viremia can be suppressed to below detectable levels in the infected individuals,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92496fe9d10d0706e230611c9b58feb0
https://pubmed.ncbi.nlm.nih.gov/30783503
https://pubmed.ncbi.nlm.nih.gov/30783503
Autor:
Ronel Müller, Stephen C. Pelly, Adriaan E. Basson, Nicole Pribut, Willem A. L. van Otterlo, Mohammad Hassam, Lynn Morris, Iqbal Mulani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4376-4380
The human immunodeficiency virus (HIV) pandemic remains a significant problem, especially in developing nations where the social and economic impacts are severe. Until a cure or vaccine for the disease is found, a constant supply of new compounds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3bbade8180ae4e5a066fb43c9fcc70
https://doi.org/10.1016/j.bmcl.2014.08.020
https://doi.org/10.1016/j.bmcl.2014.08.020
Autor:
Adriaan E. Basson, Willem A. L. van Otterlo, Clinton G. L. Veale, Stephen C. Pelly, Nicole Pribut
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
The development of novel anti-HIV agents remains an important medicinal chemistry challenge given that no cure for the disease is imminent, and the continued use of current NNRTIs inevitably leads to problems associated with resistance. Inspired by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a001695553acbda290daf19e3fc6c976
https://pubmed.ncbi.nlm.nih.gov/27287366
https://pubmed.ncbi.nlm.nih.gov/27287366
Autor:
Adriaan E. Basson, Margaret A.L. Blackie, Siobhan Brigg, Willem A. L. van Otterlo, Moscos Avgenikos, Stephen C. Pelly, Nicole Pribut, Reinhardt Venter
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
In a previous communication we described a series of indole based NNRTIs which were potent inhibitors of HIV replication, both for the wild type and K103N strains of the virus. However, the methyl ether functionality on these compounds, which was cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b5363fb7aab3d92610683dfcd5aef1
https://pubmed.ncbi.nlm.nih.gov/26876929
https://pubmed.ncbi.nlm.nih.gov/26876929