Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nicole Plank"'
Publikováno v:
Molbank, Vol 2022, Iss 3, p M1437 (2022)
The title compound (S)-3-(3-((7-ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile (2) was synthesized in five steps, starting from 4-chloro-7-iodo-9H-pyrimido[4,5-b]indole (3), and was characterized by 1H-NMR, 13C-NMR, MS and H
Externí odkaz:
https://doaj.org/article/09f9b6b7003d44e386cf2c71cfb3b500
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 264 (2023)
The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-me
Externí odkaz:
https://doaj.org/article/9a6fd8a70a674c2e9e584d2d2ad88fe1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9739 (2021)
G protein activation represents an early key event in the complex GPCR signal transduction process and is usually studied by label-dependent methods targeting specific molecular events. However, the constrained environment of such “invasive” tech
Externí odkaz:
https://doaj.org/article/c15deab3006143ce9f22ff5a079cca50
Publikováno v:
Journal of Medicinal Chemistry. 63:13090-13102
Currently employed histamine H2 receptor (H2R) radioligands possess several drawbacks, for example, high non-specificity, insurmountable binding, or short half-life. We report the synthesis and the chemical and pharmacological characterization of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8915a09f7d4787c4c6058489196e0ff
https://doi.org/10.1021/acs.jmedchem.0c01494
https://doi.org/10.1021/acs.jmedchem.0c01494
Publikováno v:
Journal of Measurements in Engineering, Vol 8, Iss 1, Pp 15-26 (2020)
Optical levers for precision angle measurement have the advantage of exerting only a negligible force on the object being measured. Also, in autocollimating configuration, optical levers are insensitive to longitudinal movements of the target mirror.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6740e6980e346574da04fcb15d57dac
https://doi.org/10.21595/jme.2020.21210
https://doi.org/10.21595/jme.2020.21210
Publikováno v:
Journal of medicinal chemistry. 63(21)
Currently employed histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bb0f7dbbcc5824555083117d38f17b4
https://pubmed.ncbi.nlm.nih.gov/33108724
https://pubmed.ncbi.nlm.nih.gov/33108724
Autor:
Guenther Bernhardt, Peter Schmidt, David Wifling, Bo Xu, Kerstin Burkert, Qiang Zhao, Cuiying Yi, Max Keller, Rongguang Zhang, Raymond C. Stevens, Beibei Li, Daniel Huster, Beili Wu, Timo Littmann, Anette Kaiser, Shuo Han, Lisa Maria Kögler, Mathias Bosse, Armin Buschauer, Sheng Ye, Jens Meiler, Dan Larhammar, Nicole Plank, Zhenlin Yang, Annette G. Beck-Sickinger, Brian J. Bender
Publikováno v:
Nature
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology(1,2). The NPY-Y receptor system has emerged as one of the most complex networks with three peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c7c85e188410a47148a2b5ceedc71f
https://doi.org/10.1038/s41586-018-0046-x
https://doi.org/10.1038/s41586-018-0046-x
Autor:
Thorsten Schäfer, Joachim Wegener, Sebastian Lieb, Timo Littmann, Günther Bernhardt, Miho Tanaka, Kristina Friedland, Armin Buschauer, Stéphane Krief, Sigurd Elz, Takeaki Ozawa, Nicole Plank, Johannes Felixberger
Publikováno v:
Pharmacological Research. 114:13-26
A set of histamine H1 receptor (H1R) agonists and antagonists was characterized in functional assays, using dynamic mass redistribution (DMR), electric cell-substrate impedance sensing (ECIS) and various signaling pathway specific readouts (Fura-2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7070fd392bd258bb0676b1a86d15024
https://doi.org/10.1016/j.phrs.2016.10.010
https://doi.org/10.1016/j.phrs.2016.10.010
Autor:
Joachim Wegener, Armin Buschauer, Stefanie Michaelis, Günther Bernhardt, Sebastian Lieb, Nicole Plank
Publikováno v:
Pharmacological research. 108
Label-free cell-based assays have been attracting growing attention in drug research. Optical approaches based on evanescent electric fields (e.g. EPIC, RWG/DMR, SPR) and electrochemical impedance analysis (ECIS, xCELLigence) are by far the most wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f7b4f7d7eee3dd27249be94268c5c7
https://pubmed.ncbi.nlm.nih.gov/27133553
https://pubmed.ncbi.nlm.nih.gov/27133553
Autor:
Nicole Plank, Agnes Boltz, Rainer Tobisch, Gerhard Garhöfer, Wolfgang Brezna, Leopold Schmetterer, Nikolaus Dragostinoff, Reinhard Told, Kirsten Lux, Katarzyna J. Witkowska, Christian Krutzler
Publikováno v:
Translational Vision Science & Technology
Purpose The visual performance of monofocal, bifocal, and trifocal intraocular lenses was evaluated by human individuals using a vision simulator device. This allowed investigation of the visual impression after cataract surgery, without the need act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa6395e01bd75a354bc3527ff79cce7
https://pubmed.ncbi.nlm.nih.gov/27777828
https://pubmed.ncbi.nlm.nih.gov/27777828