PDX-derived organoids model in vivo drug response and secrete biomarkers

Autor: Ling Huang, Bruno Bockorny, Indranil Paul, Dipikaa Akshinthala, Pierre-Oliver Frappart, Omar Gandarilla, Arindam Bose, Veronica Sanchez-Gonzalez, Emily E. Rouse, Sylvain D. Lehoux, Nicole Pandell, Christine M. Lim, John G. Clohessy, Joseph Grossman, Raul Gonzalez, Sofia Perea Del Pino, George Daaboul, Mandeep S. Sawhney, Steven D. Freedman, Alexander Kleger, Richard D. Cummings, Andrew Emili, Lakshmi B. Muthuswamy, Manuel Hidalgo, Senthil K. Muthuswamy

Publikováno v: JCI Insight, Vol 5, Iss 21 (2020)

Patient-derived organoid models are proving to be a powerful platform for both basic and translational studies. Here we conduct a methodical analysis of pancreatic ductal adenocarcinoma (PDAC) tumor organoid drug response in paired patient-derived xe

Externí odkaz: https://doaj.org/article/ece33f7ae51a4b3987a1856d60d1d5c9

Table S1 from NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants

Autor: Christopher J. Sweeney, Leigh Ellis, Nicole Pandell, John G. Clohessy, Anis A. Hamid, Katherine L. Morel

List of qPCR primers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6986e348e63a6a59593513f236e446eb
https://doi.org/10.1158/1541-7786.22525904

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Autor: Olivier Kocher, Maria Cristina Magli, Marzia Del Re, Sam Fox, Assunta De Rienzo, Barbara Storti, Virginia Savova, Mahmoud A. Bassal, Rapolas Zilionis, Kimberly Vermilya, Stefania Crucitta, Art Branstrom, Elena Levantini, Eva Csizmadia, Claire V. Meyerovitz, Riccardo Panella, Rachel D. Levy, Valerie A. Maymi, Chee Wai Fhu, Daniela S. Basseres, Henry Yang, Alessandra Giorgetti, Marla Weetall, Raphael Bueno, Raffaele Ciampi, Giorgia Maroni, Julio Castaño, Corinne E. Gustafson, John G. Clohessy, Ranieri Bizzarri, Nicole Pandell, Azhar Ali, Allon M. Klein, Indira Krishnan, Jia Li, Junyan Zhang, Daniel G. Tenen, Romano Danesi, Robert S. Welner, Peter J. Tramontozzi

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Communications biology, Berlin : Nature research, 2021, vol. 4, iss. 1, art. no. 370, p. [1-15]
Communications Biology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications biology 4 (2021): 370-1–370-15. doi:10.1038/s42003-021-01897-6
info:cnr-pdr/source/autori:Maroni G.; Bassal M.A.; Krishnan I.; Fhu C.W.; Savova V.; Zilionis R.; Maymi V.A.; Pandell N.; Csizmadia E.; Zhang J.; Storti B.; Castano J.; Panella R.; Li J.; Gustafson C.E.; Fox S.; Levy R.D.; Meyerovitz C.V.; Tramontozzi P.J.; Vermilya K.; De Rienzo A.; Crucitta S.; Basseres D.S.; Weetall M.; Branstrom A.; Giorgetti A.; Ciampi R.; Del Re M.; Danesi R.; Bizzarri R.; Yang H.; Kocher O.; Klein A.M.; Welner R.S.; Bueno R.; Magli M.C.; Clohessy J.G.; Ali A.; Tenen D.G.; Levantini E./titolo:Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer/doi:10.1038%2Fs42003-021-01897-6/rivista:Communications biology/anno:2021/pagina_da:370-1/pagina_a:370-15/intervallo_pagine:370-1–370-15/volume:4

Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb8c66e11c1d739999424c93142dd2a
http://hdl.handle.net/2445/177192

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

Autor: Sofia Perea Del Pino, Emily E Rouse, Ling Huang, John G. Clohessy, Omar Gandarilla, Senthil K. Muthuswamy, Veronica Sanchez-Gonzalez, Andrew Emili, Joseph Grossman, Manuel Hidalgo, Dipikaa Akshinthala, Arindam Bose, Raul S. Gonzalez, Lakshmi Muthuswamy, Mandeep S. Sawhney, Indranil Paul, George G. Daaboul, Steven D. Freedman, Nicole Pandell, Bruno Bockorny, Richard D. Cummings, Sylvain Lehoux

Patient-derived models are transforming translational cancer research. It is not clear if the emergence of patient-derived organoid (PDO) models can extend the utility of the widely used patient-derived xenograft (PDX). In addition, the utility of PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91793f2dfb6bb000937a5337ba422e8
https://doi.org/10.1101/513267

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Autor: Alvaro C. Laga, John M. Asara, Howard Y. Chang, Justin L. Tan, Brian T. Do, Leonard I. Zon, Anne Bothmer, Richard M. White, David H. Price, Ng Shyh-Chang, Ryan A. Flynn, Nicole Pandell, Song Yang, Violaine Saint-André, Yoon Jung Kim, Zi Peng Fan, Koh Fujinaga, Elliott J. Hagedorn, Serine Avagyan, Tae Hoon Kim, Cristina Santoriello, B. Matija Peterlin, Ellen van Rooijen, John G. Clohessy, John E. Brogie, Richard A. Young, Celeste B. Greer, Yi Zhou, Pier Paolo Pandolfi, Rachel D. Fogley, Julien Ablain

Publikováno v: Molecular Cell
Molecular Cell, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
Molecular Cell, Elsevier, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
PMC
Molecular cell, vol 62, iss 1

International audience; Studying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities. In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor suppressor that responds to nucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2be414500e23e7e55cf569d834dacf
https://hal-pasteur.archives-ouvertes.fr/pasteur-02871949