Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Nicole Paczia"'
Autor:
Hai He, Paul A. Gómez-Coronado, Jan Zarzycki, Sebastian Barthel, Jörg Kahnt, Peter Claus, Moritz Klein, Melanie Klose, Valérie de Crécy-Lagard, Daniel Schindler, Nicole Paczia, Timo Glatter, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Promiscuous enzymes often serve as the starting point for the evolution of novel functions. Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several times independently for different purposes during evolution
Externí odkaz:
https://doaj.org/article/5f1a2364ec8a465f91e3ac80a6c06931
Autor:
Giovanni Scarinci, Jan-Luca Ariens, Georgia Angelidou, Sebastian Schmidt, Timo Glatter, Nicole Paczia, Victor Sourjik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract While different stages of mutualism can be observed in natural communities, the dynamics and mechanisms underlying the gradual erosion of independence of the initially autonomous organisms are not yet fully understood. In this study, by cond
Externí odkaz:
https://doaj.org/article/b0741e1c1ee24f9d91908cdc3fe645a6
Autor:
Helena Schulz-Mirbach, Jan Lukas Krüsemann, Theofania Andreadaki, Jana Natalie Nerlich, Eleni Mavrothalassiti, Simon Boecker, Philipp Schneider, Moritz Weresow, Omar Abdelwahab, Nicole Paczia, Beau Dronsella, Tobias J. Erb, Arren Bar-Even, Steffen Klamt, Steffen N. Lindner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Anaerobic microbial fermentations provide high product yields and are a cornerstone of industrial bio-based processes. However, the need for redox balancing limits the array of fermentable substrate-product combinations. To overcome this lim
Externí odkaz:
https://doaj.org/article/70455d7d634d43588ef2f556c5b5c224
Autor:
Aranzazu Arias-Rojas, Adini Q Arifah, Georgia Angelidou, Belal Alshaar, Ursula Schombel, Emma Forest, Dagmar Frahm, Volker Brinkmann, Nicole Paczia, Chase L Beisel, Nicolas Gisch, Igor Iatsenko
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012462 (2024)
Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacterized. To cl
Externí odkaz:
https://doaj.org/article/0c6cb570cd50400c90092644d5058a49
Autor:
Lennart Schada von Borzyskowski, Lucas Hermann, Katharina Kremer, Sebastian Barthel, Bianca Pommerenke, Timo Glatter, Nicole Paczia, Erhard Bremer, Tobias J. Erb
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The hydroxyacid glycolate is a highly abundant carbon source in the environment. Glycolate is produced by unicellular photosynthetic organisms and excreted at petagram scales to the environment, where it serves as growth substrate for hetero
Externí odkaz:
https://doaj.org/article/86cb0367fb6d4e4992e9eb5c88e1bb4c
Autor:
Karin Schann, Jenny Bakker, Maximilian Boinot, Pauline Kuschel, Hai He, Maren Nattermann, Nicole Paczia, Tobias Erb, Arren Bar‐Even, Sebastian Wenk
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Formaldehyde is a key metabolite in natural and synthetic one‐carbon metabolism. To facilitate the engineering of formaldehyde‐producing enzymes, the development of sensitive, user‐friendly, and cost‐effective detection methods is re
Externí odkaz:
https://doaj.org/article/09741b6af7a5420e9d4900c7ce3bfc16
Autor:
Marie Burt, Georgia Angelidou, Christopher Nils Mais, Christian Preußer, Timo Glatter, Thomas Heimerl, Rüdiger Groß, Javier Serrania, Gowtham Boosarpu, Elke Pogge von Strandmann, Janis A. Müller, Gert Bange, Anke Becker, Mareike Lehmann, Danny Jonigk, Lavinia Neubert, Hinrich Freitag, Nicole Paczia, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract The continuous emergence of multidrug‐resistant bacterial pathogens poses a major global healthcare challenge, with Klebsiella pneumoniae being a prominent threat. We conducted a comprehensive study on K. pneumoniae’s antibiotic resistan
Externí odkaz:
https://doaj.org/article/d578823b51904a85bb20616a75988ddc
Autor:
José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and ADP-ribose (ADPR). Here, we use LC-MS/MS and NAD captureSeq to
Externí odkaz:
https://doaj.org/article/b2bd0d8d07d04d60867ee100d9ab99d3
Autor:
Björn Klabunde, André Wesener, Wilhelm Bertrams, Isabell Beinborn, Nicole Paczia, Kristin Surmann, Sascha Blankenburg, Jochen Wilhelm, Javier Serrania, Kèvin Knoops, Eslam M. Elsayed, Katrin Laakmann, Anna Lena Jung, Andreas Kirschbaum, Sven Hammerschmidt, Belal Alshaar, Nicolas Gisch, Mobarak Abu Mraheil, Anke Becker, Uwe Völker, Evelyn Vollmeister, Birke J. Benedikter, Bernd Schmeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic l
Externí odkaz:
https://doaj.org/article/f53e17d7ffee4a8b866fd16db80c5bb8
Autor:
Maren Nattermann, Sebastian Wenk, Pascal Pfister, Hai He, Seung Hwan Lee, Witold Szymanski, Nils Guntermann, Fayin Zhu, Lennart Nickel, Charlotte Wallner, Jan Zarzycki, Nicole Paczia, Nina Gaißert, Giancarlo Franciò, Walter Leitner, Ramon Gonzalez, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO2 by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered microbes. A key step in expanding syn
Externí odkaz:
https://doaj.org/article/e3ea1543e7bb47f085fc0b1f3974546b