Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics

Autor: Ran Ran, Javier Muñoz Briones, Smrutiti Jena, Nicole L. Anderson, Matthew R. Olson, Leopold N. Green, Douglas K. Brubaker

Publikováno v: iScience, Vol 27, Iss 4, Pp 109383- (2024)

Summary: The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an in vitro gut mimic, yet the translatability of insights from such a system to adult human physiological contexts is not full

Externí odkaz: https://doaj.org/article/f1236eabc5364a3ba232ca68f709454f

Using co-creation focus groups to customise a remote multidomain programme designed to increase dementia literacy

Autor: Aravind Ganesh, Teresa Liu-Ambrose, Natalie Phillips, Kenneth Rockwood, Edeltraut Kröger, Nathan Herrmann, Guangyong Zou, Paul Mick, Serge Gauthier, Walter Wittich, Marie-Céline Lorenzini, Danielle Laurin, Gillian Einstein, Jennifer Bethell, Eric Smith, Karen Messer, Caroline Duchaine, Andrew Hamilton, Heather Keller, Barry Greenberg, Lesley Miller, Susan Marzolini, Robin Hsiung, Jennifer Campos, Jennifer Walker, Catherine Hughes, Nicole Gervais, Andrew Centen, Louis Bherer, Brigitte Gilbert, Amanda Wagner, Katherine Siminovitch, Laura Middleton, Carol Thomas, Andrew Lim, Nicole Anderson, Quincy Almeida, Ron Postuma, Nadia Gosselin, Howard Feldman, Alan Evans, Howard Chertkow, Nellie Kamkar, Manuel Montero-Odasso, Mark Speechley, Bill McIlroy, Richard Camicioli, Roger Marple, Raed Joundi, Chris McGibbon, Linda Yetman, Bryn Robinson, Sylvie Belleville, Haakon Nygaard, Danielle Alcock, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Scott Hofer, Inbal Itzhak, Diane Jacobs, Jody-Lynn Lupo, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Kayla Regan, Gabrielle Aubin, Asma Fadhlaoui, Nicole D Anderson, Nouha Ben Gaied, Joyla Furlano, Pamela Jarrett, Michael Borrie, January Durant, Tatiana Herold, Yanina Sarquis-Adamson, Penelope Slack, Amal Trigui, Shahnaz Winer, Fatim Ajwani, Anas Alrohimi, Gabrielle Aubin Geneviève Arsenault-Lapierre, Maude Bouchard, Mark Boulos, Jacqueline Burt, Asif Javed Butt, Julie Carrier, Alison Chasteen, Rachel A. Crockett, Danielle D’Amico, Véronique Daneault, Thanh Dang-Vu, Alex Desautels, Caroline Desrosiers, Shirley Dumassais, Emily Dwosh, Margaret Fahnestok, Ryan Stanley Falck, Alexandra Fiocco, Christine Gagnon, Jean-François Gagnon, Liisa Galea, Catherine-Alexandra Grégoire, Stephanie Huang, Inbal Itzak, Elizaveta Klekovkina, Kim Lasnier-Le Quang, Dominique Lorrain, Kaljani Mahalingam, Sarantia Samantha Maltezos, Brooklyn Mankasingh, Samira Mehrabi, Tatiyana Mollayeva, Annabelle Moore, Aline Moussard, Reanne Mundadan, Kelly Murphy, Leigh-Anne M. Noltie, JB Orange, Emilie Parolin, Kathy Pichora-Fuller, Lori Piquette, Jason Plaks, Avery Pratt, Maria Natasha Rajah, Helli Raptis, Anne Julien-Rocheleau, Marie Y. Savundranayagam, Kylie Sullivan, Munira Sultana, Fatima Tangkhpanya, Talar Tcherkezian, Anne-Julie Tessier, Lynn Valeyry Verty, Stephanie Yamin, Anthonio Zadra, Rolando Acosta, Camille Beaudoin, Charlie Henri-Bellamare, Jessica Callegaro, Milad Heshmati, Pierre Pac Soo, Krista Lanctot, Joanne McLaurin, Paul Territo, Donald Weaver, Cheryl Wellington, Rida Abou-Haidar, Sarah Best, Korbin Blue, Isabella Celotto, Lauren Cole, Roger Dixon, Hiroko Dodge, Nada Elhayek, Thalia Field, Jason Haassenstab, Josée Hachee, Lisa Madlesnky, Lauren Moniz, Hanin Omar, Chris Pauley, Jenna Sands Ève Samson, Andrew Sexton, Sheetal Shajan, Sachie Sharma, Mariam Sidrak, Julia Truemner, François Boutin, Yves Boutot, Lise Daigle, Nita Goldband, Elaine Harris, Janet Finkelstein, Kateri Marchand, Lloyd Schneider

Publikováno v: BMJ Open, Vol 13, Iss 9 (2023)

Objectives To adapt the content and functionalities of Brain Health PRO, a web-based multidomain program designed to increase dementia literacy, to the context and needs of users, providers and community organisations across Québec, Canada.Design Fi

Externí odkaz: https://doaj.org/article/a786b6250ffb4973bb249507283a34ac

IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6

Autor: D. Alejandro Canaria, Maia G. Clare, Bingyu Yan, Charlotte B. Campbell, Zachariah A. Ismaio, Nicole L. Anderson, Sungtae Park, Alexander L. Dent, Majid Kazemian, Matthew R. Olson

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IL-9-producing CD4+ T helper cells, termed Th9 cells, differentiate from naïve precursor cells in response to a combination of cytokine and cell surface receptor signals that are elevated in inflamed tissues. After differentiation, Th9 cells accumul

Externí odkaz: https://doaj.org/article/f8a357bbff2a4fd8819701a96855a258

The Effects of Aging and Time of Day on Inhibitory Control: An Event-Related Potential Study

Autor: Rahel Rabi, Ricky Chow, Shahier Paracha, Lynn Hasher, Sandra Gardner, Nicole D. Anderson, Claude Alain

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

Time of day (TOD) influences on executive functions have been widely reported, with greater efficiency demonstrated at optimal relative to non-optimal TOD according to one’s chronotype (i.e., synchrony effect). Older adults (OAs) show declines in i

Externí odkaz: https://doaj.org/article/721cf754c1e04f7ab6ae0e61bf441e80

Cardiovascular risk and encoding-related hippocampal connectivity in older adults

Autor: Liesel-Ann C. Meusel, Carol E. Greenwood, Andrea Maione, Ekaterina Tchistiakova, Bradley J. MacIntosh, Nicole D. Anderson

Publikováno v: BMC Neuroscience, Vol 20, Iss 1, Pp 1-10 (2019)

Abstract Background Cardiovascular conditions contribute to brain volume loss, reduced cerebrovascular health, and increased dementia risk in aging adults. Altered hippocampal connectivity has also been observed in individuals with cardiovascular con

Externí odkaz: https://doaj.org/article/abeb1178c63945f69571122258d971c8