Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole Nüsgen"'
Autor:
Laurynas Daugela, Nicole Nüsgen, Maja Walier, Johannes Oldenburg, Rainer Schwaab, Osman El-Maarri
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44585 (2012)
In humans, considerable variation in methylation at single loci and repetitive elements in various cells and tissues is observed. Recently, several inter- and intra-tissue correlations for DNA methylation have been reported. To investigate the extent
Externí odkaz:
https://doaj.org/article/a915a7b7a7d14d44ae11623c90c2c61e
Autor:
Osman El-Maarri, Maja Walier, Frank Behne, Jan van Üüm, Heike Singer, Amalia Diaz-Lacava, Nicole Nüsgen, Barbara Niemann, Matthias Watzka, Jochen Reinsberg, Hans van der Ven, Thomas Wienker, Birgit Stoffel-Wagner, Rainer Schwaab, Johannes Oldenburg
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16252 (2011)
Previously, we reported on inter-individual and gender specific variations of LINE-1 methylation in healthy individuals. In this study, we investigated whether this variability could be influenced by age or sex hormones in humans. To this end, we stu
Externí odkaz:
https://doaj.org/article/176df10339f94d409a07a8a43d9efde4
Autor:
Rawya Al-Rifai, Mira Ibrahim, Doha Chrayteh, Salime El-Hazzouri, Heike Singer, Nicole Nüsgen, Johannes Oldenburg, Osman El-Maarri
Publikováno v:
52. Hamburger Hämophilie Symposion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58e53cedbca49cbdbb9266bf6327fc9
https://doi.org/10.1055/s-0042-1748631
https://doi.org/10.1055/s-0042-1748631
Publikováno v:
Hamburger Hämophilie Symposion Hamburg, Germany.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc55de355ab85b34577975528f3bddb
https://doi.org/10.1055/s-0040-1721599
https://doi.org/10.1055/s-0040-1721599
Autor:
Sascha Strauss, Melanie Rath, Muhammad Jamil, Heike Singer, Rawya Al-Rifai, Ioanna Andreou, Nicole Nüsgen, Osman El-Maarri, Johannes Oldenburg
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7776, p 7776 (2020)
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7776, p 7776 (2020)
In humans, Factor VIII (F8) deficiency leads to hemophilia A and F8 is largely synthesized and secreted by the liver sinusoidal endothelial cells (LSECs). However, the specificity and characteristics of these cells in comparison to other endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b545efc5f8f40919961efe16ce872023
Autor:
Osman El-Maarri, Markus Montag, Maria Köster, Nicole Nüsgen, Katrin van der Ven, Johannes Oldenburg, Muhammad Jamil, Hans van der Ven
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6377, p 6377 (2021)
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6377, p 6377 (2021)
To increase the efficiency of assisted reproductive techniques (ART), molecular studies have been performed to identify the best predictive biomarkers for selecting the most suitable germ cells for fertilization and the best embryo for intra-uterine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d39e41e629da71eb73dcc1addbe0bd
https://doi.org/10.3390/ijms22126377
https://doi.org/10.3390/ijms22126377
Autor:
Arijit Biswas, Wolfgang Goering, Albertas Daukša, Ioanna M. Dimitriou, Amit Sharma, Antanas Gulbinas, Heike Singer, Muhammad Jamil, Wolfgang A. Schulz, Nicole Nüsgen, Holger Fröhlich, Rolf Fimmers, Johannes Oldenburg, Osman El-Maarri
Publikováno v:
Clinical Epigenetics
Background Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LINE-1 loci or different CpGs wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b983126ec3ee2d2df1aba4e4b65e087
https://doi.org/10.1186/s13148-015-0051-y
https://doi.org/10.1186/s13148-015-0051-y
Autor:
Tim Becker, Heike Singer, Felix Schreiner, Thomas F. Wienker, Rainer Schwaab, Christian Meesters, Maja Walier, Nicole Nüsgen, Osman El-Maarri, Rolf Fimmers, Joachim Woelfle, Johannes Oldenburg, Vera M. Kalscheuer
Publikováno v:
Human molecular genetics 21(1), 219-235 (2011). doi:10.1093/hmg/ddr456
Human Molecular Genetics
Human Molecular Genetics
LINE-1 repeats account for ~17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted. Here, we used bisulfite conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c593d730b9ac87c553291ebd5fff1b8
https://pub.dzne.de/record/136370
https://pub.dzne.de/record/136370
Autor:
Per Hoffmann, Nicole Nüsgen, Markus M. Nöthen, Holger Fröhlich, Behnaz Pezeshkpoor, Andrea Hofmann, Muhammad Jamil, Stefanie Heilmann, Johannes Oldenburg, Osman El-Maarri
Publikováno v:
ResearcherID
Different endothelial cells share common features but also acquire organ specificity: for example the liver sinusoidal endothelial cells (LSECs) are major site of F8 secretion as compared to other endothelial cells. To decipher this specificity in LS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c707b39d4794a3be510be96e58a8c8c
https://doi.org/10.1182/blood.v126.23.4671.4671
https://doi.org/10.1182/blood.v126.23.4671.4671
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 791
Genome-wide sequence-specific methylation analysis has become a readily available and affordable procedure in epigenetic laboratories. Most of these procedures are based on immunoprecipitation, microarrays, or next generation deep bisulfite sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88b46fef332a93e4bb7f193dfbe6bd97
https://pubmed.ncbi.nlm.nih.gov/21913073
https://pubmed.ncbi.nlm.nih.gov/21913073