Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole Min Qian Pek"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 273-290 (2021)
Epithelial cells in the liver (known as hepatocytes) are high-performance engines of myriad metabolic functions and versatile responders to liver injury. As hepatocytes metabolize amino acids, alcohol, drugs, and other substrates, they produce and ar
Externí odkaz:
https://doaj.org/article/8cbd639ed031408ca7c8ee10358e1593
Autor:
Yong Fan, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Jin Hui Hor, Shi-Yan Ng, Boon-Seng Soh
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field (AHF) cardiac progenitor cells (CPCs) for the formation of the right ven
Externí odkaz:
https://doaj.org/article/95ec1034b7d448fe9ddccf1c4bb5b23c
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2016)
In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy. Traditionally, knowledge gathered from rodents is extended to human pancre
Externí odkaz:
https://doaj.org/article/d8e188542a274b95be3f066f95ac238a
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 936 (2018)
The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture has stemmed from the manipulation of various combinations of directed multi-lineage differentiation and morphogenetic processes that mimic organogenesis. Orga
Externí odkaz:
https://doaj.org/article/91364526bc9c422caa3d96294b789b94
Publikováno v:
Current Cardiology Reports. 24:463-471
Given a general lack of emphasis on the molecular underpinnings of single ventricle (SV) congenital heart diseases (CHD), our review highlights and summarizes recent advances in uncovering the genetic and molecular mechanisms in SV CHD etiology.While
Autor:
Jennifer Cable, Matthias P. Lutolf, Jianping Fu, Sunghee Estelle Park, Athanasia Apostolou, Shuibing Chen, Cheng Jack Song, Jason R. Spence, Prisca Liberali, Madeline Lancaster, Anna B. Meier, Nicole Min Qian Pek, James M. Wells, Meghan M. Capeling, Ana Uzquiano, Samira Musah, Meritxell Huch, Mina Gouti, Pleun Hombrink, Giorgia Quadrato, Jean‐Paul Urenda
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES. 1518(1)
Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fa
Autor:
Kai Yi Tay, Kan Xing Wu, Florence Wen Jing Chioh, Matias Ilmari Autio, Nicole Min Qian Pek, Balakrishnan Chakrapani Narmada, Sock-Hwee Tan, Adrian Fatt-Hoe Low, Michelle Mulan Lian, Elaine Guo Yan Chew, Hwee Hui Lau, Shih Ling Kao, Adrian Kee Keong Teo, Jia Nee Foo, Roger Sik Yin Foo, Chew Kiat Heng, Mark Yan Yee Chan, Christine Cheung
Background and aims: Single nucleotide polymorphism rs6903956 has been identified as one of the genetic risk factors for coronary artery disease (CAD). However, rs6903956 lies in a non-coding locus on chromosome 6p24.1. We aim to interrogate the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fca752bb9ffd58aa6c421982b80e6c
https://doi.org/10.1101/2022.07.12.499721
https://doi.org/10.1101/2022.07.12.499721
Autor:
Nicole Min Qian Pek
Publikováno v:
Journal of Regenerative Biology and Medicine.
Over the past decade, new advancements in stem cell and three-dimensional cell culture technologies have reignited interests in organoid research. The unassuming ‘blobs’ of cells made to mimic organs are revolutionizing human medicine. By utilizi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 273-290 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 273-290 (2021)
Epithelial cells in the liver (known as hepatocytes) are high-performance engines of myriad metabolic functions and versatile responders to liver injury. As hepatocytes metabolize amino acids, alcohol, drugs, and other substrates, they produce and ar
Autor:
Qian Hua Phua, Jin-Hui Hor, Yang Yu, Shi-Yan Ng, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Yong Fan, Henry He Yang, Boon Seng Soh, Omer An
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 11, Pp 1-16 (2019)
Cell Death and Disease, Vol 10, Iss 11, Pp 1-16 (2019)
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a mitochondrial disorder that is commonly caused by the m.3243A > G mutation in the MT-TL1 gene encoding for mitochondrial tRNA(Leu(UUR)). While clinical s