Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Nicole Mideo"'
Limited impact of within-vector ecology on the evolution of malaria parasite transmission investment
Publikováno v:
Frontiers in Malaria, Vol 2 (2024)
Malaria parasites spend part of their life in a vertebrate host and the rest in an arthropod vector and must successfully navigate both environments to gain fitness. In vertebrate hosts, malaria parasites infect red blood cells and can either replica
Externí odkaz:
https://doaj.org/article/0a62f8bedea747c0963e77cfbfd63cb7
Publikováno v:
Evolution Letters, Vol 5, Iss 5, Pp 458-471 (2021)
Abstract Although vaccination has been remarkably effective against some pathogens, for others, rapid antigenic evolution results in vaccination conferring only weak and/or short‐lived protection. Consequently, considerable effort has been invested
Externí odkaz:
https://doaj.org/article/9586b179b02f4185bce1743abf81d763
Autor:
Martin Krkošek, Madeline Jarvis-Cross, Kiran Wadhawan, Isha Berry, Jean-Paul R. Soucy, Korryn Bodner, Ariel Greiner, Leila Krichel, Stephanie Penk, Dylan Shea, Juan S. Vargas Soto, Ed W. Tekwa, Nicole Mideo, Péter K. Molnár
Publikováno v:
FACETS, Vol 6, Iss 1, Pp 180-194 (2021)
This study empirically quantifies dynamics of SARS-CoV-2 establishment and early spread in Canada. We developed a transmission model that was simulation tested and fitted in a Bayesian framework to timeseries of new cases per day prior to physical di
Externí odkaz:
https://doaj.org/article/188b4f22c15845ce96c64555376a3a8c
Publikováno v:
Ecology and Evolution, Vol 10, Iss 12, Pp 5748-5758 (2020)
Abstract Repeated emergence of zoonotic viruses from bat reservoirs into human populations demands predictive approaches to preemptively identify virus‐carrying bat species. Here, we use machine learning to examine drivers of viral diversity in bat
Externí odkaz:
https://doaj.org/article/df2e573baa3243f7bd74f7fa9326cf19
Publikováno v:
eLife, Vol 10 (2021)
It remains challenging to understand why some hosts suffer severe illnesses, while others are unscathed by the same infection. We fitted a mathematical model to longitudinal measurements of parasite and red blood cell density in murine hosts from div
Externí odkaz:
https://doaj.org/article/2bc5ce5170514ec38d158369f157164f
Publikováno v:
Ecosphere, Vol 12, Iss 7, Pp n/a-n/a (2021)
Abstract The costs of mounting and maintaining an immune response lead to trade‐offs with investment in (or maintenance of) other organ systems or functions such as reproduction, as has been observed in several taxa, including birds, insects, and m
Externí odkaz:
https://doaj.org/article/c479e9cf6df54235a83f04991d88f373
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1008577 (2021)
Although drug resistance in Plasmodium falciparum typically evolves in regions of low transmission, resistance spreads readily following introduction to regions with a heavier disease burden. This suggests that the origin and the spread of resistance
Externí odkaz:
https://doaj.org/article/0cfb43450415422aa0cfa90ccb8167c5
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 10, p e1008211 (2020)
To understand why some hosts get sicker than others from the same type of infection, it is essential to explain how key processes, such as host responses to infection and parasite growth, are influenced by various biotic and abiotic factors. In many
Externí odkaz:
https://doaj.org/article/b02e9788523f461d92cde4746dd4f9e7
Autor:
Tsukushi Kamiya, Megan A. Greischar, Kiran Wadhawan, Benjamin Gilbert, Krijn Paaijmans, Nicole Mideo
Publikováno v:
Epidemics, Vol 30, Iss , Pp - (2020)
Identifying ecological drivers of disease transmission is central to understanding disease risks. For vector-borne diseases, temperature is a major determinant of transmission because vital parameters determining the fitness of parasites and vectors
Externí odkaz:
https://doaj.org/article/5479156678c14ce195a732647704474e
Publikováno v:
Evolutionary Applications, Vol 11, Iss 4, Pp 442-455 (2018)
Abstract Drug resistance has been reported against all antimalarial drugs, and while parasites can evolve classical resistance mechanisms (e.g., efflux pumps), it is also possible that changes in life history traits could help parasites evade the eff
Externí odkaz:
https://doaj.org/article/387c455a192243798434cbe9aec237d1