Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nicole Mentens"'
Autor:
Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Peripheral T cell lymphoma (PTCL) not otherwise specified (NOS) is a subgroup of PTCL, which has no distinctive features and is poorly characterized at the genetic level. Here, the authors identify two fusion transcripts that activate T cell receptor
Externí odkaz:
https://doaj.org/article/969eed6176e84cfbb86762c9aa0218ee
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
TAL1 is ectopically expressed in about 30% of T-cell acute lymphoblastic leukemia (T-ALL) due to chromosomal rearrangements leading to the STIL-TAL1 fusion genes or due to non-coding mutations leading to a de novo enhancer driving TAL1 expression. An
Externí odkaz:
https://doaj.org/article/5675bd1107774dcb811fcd97b5dece6d
Publikováno v:
HemaSphere, Vol 5, Iss 9, p e637 (2021)
Externí odkaz:
https://doaj.org/article/5814ddd82546453b937ea17ecff46833
Publikováno v:
HemaSphere, Vol 2, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/9ce7a85f0f9940f7976cb61ce754ffb2
Autor:
Jo-Anne van der Krogt, Marlies Vanden Bempt, Julio Finalet Ferreiro, Nicole Mentens, Kris Jacobs, Ursula Pluys, Kathleen Doms, Ellen Geerdens, Anne Uyttebroeck, Pascal Pierre, Lucienne Michaux, Timothy Devos, Peter Vandenberghe, Thomas Tousseyn, Jan Cools, Iwona Wlodarska
Publikováno v:
Haematologica, Vol 102, Iss 9 (2017)
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by 2p23/ALK aberrations, including the classic t(2;5)(p23;q35)/NPM1-ALK rearrangement present in ~80% of cases and several variant t(2p23/ALK) occurring in the
Externí odkaz:
https://doaj.org/article/bd7dbfd30f014255b4ea1dc1fa9f3bb3
Autor:
Kim De Keersmaecker, Michaël Porcu, Luk Cox, Tiziana Girardi, Roel Vandepoel, Joyce Op de Beeck, Olga Gielen, Nicole Mentens, Keiryn L. Bennett, Oliver Hantschel
Publikováno v:
Haematologica, Vol 99, Iss 1 (2014)
The NUP214-ABL1 fusion protein is a constitutively active protein tyrosine kinase that is found in 6% of patients with T-cell acute lymphoblastic leukemia and that promotes proliferation and survival of T-lymphoblasts. Although NUP214-ABL1 is sensiti
Externí odkaz:
https://doaj.org/article/4460a43707d945168167078489fd1bd0
Autor:
Zeynep Kalender Atak, Valentina Gianfelici, Gert Hulselmans, Kim De Keersmaecker, Arun George Devasia, Ellen Geerdens, Nicole Mentens, Sabina Chiaretti, Kaat Durinck, Anne Uyttebroeck, Peter Vandenberghe, Iwona Wlodarska, Jacqueline Cloos, Robin Foà, Frank Speleman, Jan Cools, Stein Aerts
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003997 (2013)
RNA-seq is a promising technology to re-sequence protein coding genes for the identification of single nucleotide variants (SNV), while simultaneously obtaining information on structural variations and gene expression perturbations. We asked whether
Externí odkaz:
https://doaj.org/article/c071ae03c1c64656a02630ecaab2c10c
Publikováno v:
Haematologica, Vol 96, Iss 5 (2011)
The mouse pro-B cell line Ba/F3 has gained major interest as a model system to investigate oncogenic tyrosine kinases and to determine the efficacy of kinase inhibitors. While Ba/F3 cells are suitable to study oncogenic kinases derived from various c
Externí odkaz:
https://doaj.org/article/3317eaac33f646248b86ee7de8525e8e
Autor:
Kim De Keersmaecker, Idoya Lahortiga, Nicole Mentens, Cedric Folens, Leander Van Neste, Sofie Bekaert, Peter Vandenberghe, Maria D. Odero, Peter Marynen, Jan Cools
Publikováno v:
Haematologica, Vol 93, Iss 4 (2008)
Background Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with γ-secretase inhibitors causes cell cycle block, but only after treatment for several days. We further documented the effect
Externí odkaz:
https://doaj.org/article/39823d40c1414292b05a844cedcf4544
Autor:
Idoya Lahortiga, Cem Akin, Jan Cools, Todd M. Wilson, Nicole Mentens, Diane C. Arthur, Irina Maric, Pierre Noel, Can Kocabas, Peter Marynen, Lawrence S. Lessin, Iwona Wlodarska, Jamie Robyn, Dean D. Metcalfe
Publikováno v:
Haematologica, Vol 93, Iss 1 (2008)
Background Translocations involving region 5q31-32 (PDGFRB) have been reported in a variety of myeloproliferative diseases and are often associated with significant peripheral eosinophilia. We report an unusual case of a patient presenting with perip
Externí odkaz:
https://doaj.org/article/a771c1c5e2224887949050c99c46691e