Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicole Maphis"'
Autor:
Jessica Binder, Oleg Ursu, Cristian Bologa, Shanya Jiang, Nicole Maphis, Somayeh Dadras, Devon Chisholm, Jason Weick, Orrin Myers, Praveen Kumar, Jeremy J. Yang, Kiran Bhaskar, Tudor I. Oprea
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Jessica Binder et al. developed a machine learning model to discover potential drug targets for Alzheimer’s disease. They validated their 20 top candidates in several in vitro models, and highlight FRRS1, CTRAM, SCGB3A1, FAM92B/CIBAR2, and TMEFF2 a
Externí odkaz:
https://doaj.org/article/eafe528a0fb444148715ee8fe57ec23e
Autor:
Kiran Bhaskar, Nicole Maphis, Guixiang Xu, Nicholas H. Varvel, Olga N. Kokiko-Cochran, Jason P. Weick, Susan M. Staugaitis, Astrid Cardona, Richard M. Ransohoff, Karl Herrup, Bruce T. Lamb
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 273-285 (2014)
Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However, the mechanisms are still unclear. Here we demonstrate that neuroinflammation, cell autonomous to microglia, is capable of inducing neuronal cell cycle events (
Externí odkaz:
https://doaj.org/article/aa7b7a2767a347dda18b20f23efe615d
Autor:
Soiba Khalid Mansoor, Laurel O. Sillerud, Judy L. Cannon, David S. Peabody, Fadi A. Jamaleddin Ahmad, Jonathan L. Brigman, Erin Crossey, Kiran Bhaskar, Yirong Yang, Amanda Yaney, Julianne Peabody, Bryce Chackerian, Colin M. Wilson, Maria Alvarez, Nicole Maphis, Shanya Jiang, Reed Selwyn
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline and could be caused by the aggregation of hyperphosphorylated pathological ta
Autor:
Kiran Bhaskar, Stephen D. Jett, Jason P. Weick, Shanya Jiang, Michael T. Heneka, Nicole Maphis, Nikolaos Mellios, Crina M. Floruta, Jessica L. Binder, Walter A. Duran, Eileen H. Bigio, Devon Chisholm, Changiz Geula, Lea L. Weston, Amber Zimmerman, Eicke Latz
Publikováno v:
SSRN Electronic Journal.
Pathological aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1s. First, pTau burden correlates with increased IL-1β and infl
Autor:
Michael T. Heneka, Devon Chisholm, Lea L. Weston, Nicole Maphis, Amber Zimmerman, Stephen D. Jett, Jason P. Weick, Changiz Geula, Gary A. Rosenberg, Michael A. Mandell, Jessica L. Binder, Walter A. Duran, Shanya Jiang, Nikolaos Mellios, Eicke Latz, Eileen H. Bigio, Crina M. Peterson, Kiran Bhaskar
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 12, Pp 109720-(2021)
Cell Reports, Vol 36, Iss 12, Pp 109720-(2021)
SUMMARY Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analys
Autor:
Ki-Wook Kim, Steffen Jung, Samuel D. Crish, Judy L. Cannon, Nicole Maphis, Guixiang Xu, Astrid E. Cardona, Kiran Bhaskar, Shane Formica, Bruce T. Lamb, Olga N. Kokiko-Cochran, Gina N. Wilson, Crystal M. Miller, Shane M. Bemiller
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Background Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx 3 cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still uncl
Autor:
Jeffery F. Thompson, Laurel O. Sillerud, Kiran Bhaskar, Sulaiman Iqbal, Erik B. Erhardt, Nicole Maphis, Arvind Caprihan, Lea L. Weston, Candice S Espinoza, Quanguang Zhang, Gary A. Rosenberg, John Weaver, Limor Raz, Sandro Marini, John C. Pesko
Publikováno v:
Neurobiology of Disease, Vol 126, Iss, Pp 124-136 (2019)
BACKGROUND: Hypertension-induced microvascular brain injury is a major vascular contributor to cognitive im-pairment and dementia. We hypothesized that chronic hypoxia promotes the hyperphosphorylation of tau and cell death in an accelerated spontane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2a9ba98f8534f6b7c6bc4ed495fc65
https://europepmc.org/articles/PMC6347559/
https://europepmc.org/articles/PMC6347559/
Autor:
Astrid E. Cardona, Shanya Jiang, Nicole Maphis, Kiran Bhaskar, Guixiang Xu, Olga N. Kokiko-Cochran, Bruce T. Lamb, Richard M. Ransohoff
Publikováno v:
Brain. 138:1738-1755
Pathological aggregation of tau is a hallmark of Alzheimer's disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment
Autor:
Nicole Maphis, Jessica L. Binder, Banu Gopalan, Carrie Wright, Shanya Jiang, Kiran Bhaskar, Bruce T. Lamb
Publikováno v:
Frontiers in Molecular Neuroscience
Increasing evidence suggests that hyperphosphorylation and aggregation of microtubule-associated protein tau (MAPT or tau) correlates with the development of cognitive impairment in Alzheimer’s disease (AD) and related tauopathies. While numerous a
Autor:
Adeline M. Fanni, Patrick L. Donabedian, Kiran Bhaskar, David G. Whitten, Nicole Maphis, Florencia A. Monge, Eva Y. Chi
Publikováno v:
Biophysical Journal. 114:20a-21a