Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nicole M. Thomson"'
Autor:
Linda B. von Weymarn, Xiaotong Lu, Nicole M. Thomson, Loic LeMarchand, Sungshim L. Park, Sharon E. Murphy
Publikováno v:
Chem Res Toxicol
Smoking intensity varies across smokers and is influenced by individual variability in the metabolism of nicotine, the major addictive agent in tobacco. Therefore, lung cancer risk, which varies by racial ethnic group is influenced by the primary cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e900c73b74bcfb72af3742a167c07a6b
https://doi.org/10.1021/acs.chemrestox.2c00413
https://doi.org/10.1021/acs.chemrestox.2c00413
Autor:
Stephen S. Hecht, Nicole M Thomson, Katelyn M. Tessier, Ellen Meier, Sharon E. Murphy, Dorothy K. Hatsukami, Xianghua Luo, Steven G. Carmella, Laura Dick
Publikováno v:
Nicotine Tob Res
Introduction Studies suggest tobacco and cannabis co-users may experience greater toxicant exposure than exclusive cigarette (ET) smokers. No study has systematically tested differences in toxicant exposure among co-users, exclusive cannabis (ECa) sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46faf2f611536393b5256a69515173de
https://doi.org/10.1093/ntr/ntab125
https://doi.org/10.1093/ntr/ntab125
Autor:
Sungshim L. Park, Loic Le Marchand, Guang Cheng, Silvia Balbo, Menglan Chen, Steven G. Carmella, Nicole M. Thomson, Younghan Lee, Yesha M. Patel, Daniel O. Stram, Joni Jensen, Dorothy K. Hatsukami, Sharon E. Murphy, Stephen S. Hecht
Publikováno v:
Chem Res Toxicol
The Multiethnic Cohort Study has demonstrated that the risk for lung cancer in cigarette smokers among three ethnic groups is highest in Native Hawaiians, intermediate in Whites, and lowest in Japanese Americans. We hypothesized that differences in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b142f47c60e737c4bb2fca360e6c9239
https://europepmc.org/articles/PMC10019528/
https://europepmc.org/articles/PMC10019528/
Autor:
Menglan Chen, Steven G. Carmella, Bruce R. Lindgren, Xianghua Luo, Joshua Ikuemonisan, Brittany Niesen, Nicole M. Thomson, Sharon E. Murphy, Dorothy K. Hatsukami, Stephen S. Hecht
Publikováno v:
Chem Res Toxicol
Carcinogen and toxicant uptake by e-cigarette users have not been fully evaluated. In the study reported here, we recruited 30 e-cigarette users, 63 non-smokers, and 33 cigarette smokers who gave monthly urine samples over a period of 4-6 months. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecb5433d8cfe67a922bdada5e4efda2
https://europepmc.org/articles/PMC9852357/
https://europepmc.org/articles/PMC9852357/
Autor:
Irina Stepanov, Joni Jensen, Silvia Balbo, Peter W. Villalta, Benedikt Warth, Dorothy K. Hatsukami, Nicole M. Thomson, Romel P Dator
Publikováno v:
Chemical Research in Toxicology
African American (AA) smokers are at a higher risk of developing lung cancer compared to whites. The variations in the metabolism of nicotine and tobacco-derived carcinogens in these groups were reported previously with the levels of nicotine metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7debaa605cc91fa5449acfd9d5a3326
https://doi.org/10.1021/acs.chemrestox.0c00064
https://doi.org/10.1021/acs.chemrestox.0c00064
Autor:
Eric C. Donny, Sharon E. Murphy, Dorothy K. Hatsukami, Nicole M. Thomson, Linda B. von Weymarn
Publikováno v:
Chemical research in toxicology. 29(3)
Nicotine is the most abundant alkaloid in tobacco accounting for 95% of the alkaloid content. There are also several minor tobacco alkaloids; among these are nornicotine, anatabine, and anabasine. We developed and applied a 96 well plate-based capill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082d59fcff67fee6d27f322145ef90b2
https://pubmed.ncbi.nlm.nih.gov/26825008
https://pubmed.ncbi.nlm.nih.gov/26825008
Autor:
Adam R. Benoit, Michael J. Stark, Nicole M. Thomson, Barbara A. Pizacani, Steven G. Carmella, Clyde W. Dent, Kristen Rohde, Julie E. Maher, Stephen S. Hecht, Ronda S. Bard
Publikováno v:
American Journal of Public Health. 97:1457-1463
Objectives. We studied the impact of clean indoor air law exemptions and preemption policies on the prevalence of a tobacco-specific lung carcinogen—4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)—among nonsmoking bar and restaurant workers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d9b1782596203b76ca6d557a8af34
https://doi.org/10.2105/ajph.2006.094086
https://doi.org/10.2105/ajph.2006.094086
Autor:
Natalia Y. Tretyakova, Renée S. Mijal, Anthony E. Pegg, Nancy L. Fleischer, Lisa A. Peterson, Rebecca Ziegel, Nicole M. Thomson
Publikováno v:
Chemical Research in Toxicology. 17:1600-1606
Liquid chromatography with electrospray tandem mass spectrometry (LC/ESI-MS/MS) was employed to quantify O6-[4-oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine (O6-pobdG), a mutagenic adduct formed by pyridyloxobutylating nitrosamines. Selected reaction mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fdeafc2e54afa76d56c09e5257bbb8
https://doi.org/10.1021/tx0498298
https://doi.org/10.1021/tx0498298
Autor:
Daniel P. Predecki, Elizabeth E. Donaldson, Peter W. Villalta, Nicole M. Thomson, Lisa A. Peterson
Publikováno v:
Chemical Research in Toxicology. 16:661-667
4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB) is a metabolite of the tobacco specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). HPB is also a breakdown product of covalently bound pyridyloxobutyl a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0699ce4b46179d419b131dbefd65b404
https://doi.org/10.1021/tx025676h
https://doi.org/10.1021/tx025676h
Autor:
Robert C. Moschel, Qingming Fang, Nancy L. Fleischer, Renée S. Mijal, Lisa A. Peterson, and Anthony E. Pegg, Nicole M. Thomson, Gary T. Pauly, Sreenivas Kanugula
Publikováno v:
Chemical research in toxicology. 17(3)
The tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent pulmonary carcinogen, both methylates and pyridyloxobutylates DNA. Both reaction pathways generate promutagenic O 6 -alkylguanine adducts. These adducts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e8301c4856ead800b0c2fb2f6207be
https://pubmed.ncbi.nlm.nih.gov/15025514
https://pubmed.ncbi.nlm.nih.gov/15025514