Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicole M. Hewlett"'
Autor:
Qiang Yang, Lawrence C. Creemer, Peter L. Johnson, James A. Knobelsdorf, Benjamin M. Nugent, Carl V. De Amicis, Sarah Ryan, Elizabeth O. McCusker, Gregory T. Whiteker, Nakyen Choy, Beth A. Lorsbach, Nicole M. Hewlett, Fangzheng Li, Belgin Canturk, Nicholas R. Babij, Michelle Smith
Publikováno v:
Organic Process Research & Development. 20:661-667
The 1H and 13C NMR chemical shifts of 48 industrially preferred solvents in six commonly used deuterated NMR solvents (CDCl3, acetone-d6, DMSO-d6, acetonitrile-d3, methanol-d4, and D2O) are reported. This work supplements the compilation of NMR data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6733ab91ec0b5f33e0e6e0e699eaeede
https://doi.org/10.1021/acs.oprd.5b00417
https://doi.org/10.1021/acs.oprd.5b00417
Publikováno v:
Angewandte Chemie International Edition. 54:2830-2833
The proteasome represents an invaluable target for the treatment of cancer and autoimmune disorders. The application of proteasome inhibitors, however, remains limited to blood cancers because their reactive headgroups and peptidic scaffolds convey u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71abc6fcad88fe2425e0b77babd01ab4
https://doi.org/10.1002/anie.201410168
https://doi.org/10.1002/anie.201410168
Autor:
Jetze J. Tepe, Shun Su, Ken S. Feldman, Amanda P. Skoumbourdis, Matthew D. Fodor, Ian B. Seiple, Theresa A. Lansdell, Nicole M. Hewlett, Phil S. Baran
Publikováno v:
Journal of Natural Products. 75:980-985
We report herein that the oroidin-derived alkaloids palau'amine (1), dibromophakellin (2), and dibromophakellstatin (3) inhibit the proteolytic activity of the human 20S proteasome as well as the (i)20S immunoproteasome catalytic core. Palau'amine is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086015ee96ec9715b13d2a648e483f8
https://doi.org/10.1021/np300231f
https://doi.org/10.1021/np300231f
Autor:
Jetze J. Tepe, Nicole M. Hewlett
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[1199-01-5] C9H7NO2 (MW 161.16) InChI = 1S/C9H7NO2/c11-8-6-10-9(12-8)7-4-2-1-3-5-7/h1-5H,6H2 InChIKey = QKCKCXFWENOGER-UHFFFAOYSA-N (reagent used as a masked glycine equivalent and for the formation of heterocyclic structures) Alternate Name: 2-pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fbb9ce1b95ca2ef8f6c139c281e35eb
https://doi.org/10.1002/047084289x.rn01743
https://doi.org/10.1002/047084289x.rn01743
Autor:
Nicole M. Hewlett, Jetze J. Tepe
(±)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b36075ccc695da939203afee581558
https://europepmc.org/articles/PMC3162990/
https://europepmc.org/articles/PMC3162990/
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0366a0bee23457b4aa4ec2e0768af1ee
https://doi.org/10.1002/chin.201003123
https://doi.org/10.1002/chin.201003123
Autor:
Nicole M. Hewlett, Jetze J. Tepe
Publikováno v:
Organic Letters; Sep2011, Vol. 13 Issue 17, p4550-4553, 4p