Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Nicole M. Anders"'
Autor:
Shefali Chauhan, Emily Lian, Iman Habib, Qianqian Liu, Nicole M. Anders, Megan M. Bugg, Noah C. Federman, Joel M. Reid, Clinton F. Stewart, Tristan Cates, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 + ARMS ofte
Externí odkaz:
https://doaj.org/article/f0d777b3277b40b58dcedcf300719a97
Autor:
Maggie Li, Barbara J. Smith, Jaeyeun Lee, Jennifer Petr, Nicole M. Anders, Robyn Wiseman, Michelle A. Rudek, Richard F. Ambinder, Prashant J. Desai
Publikováno v:
Infectious Agents and Cancer, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Antiviral therapies that target herpesviruses are clinically important. Nelfinavir is a protease inhibitor that targets the human immunodeficiency virus (HIV) aspartyl protease. Previous studies demonstrated that this drug could a
Externí odkaz:
https://doaj.org/article/5c85366898714cc8a83db117ba7dffca
Autor:
Amanda B. Kagan, Dominique A. Garrison, Nicole M. Anders, Jonathan A. Webster, Sharyn D. Baker, Srinivasan Yegnasubramanian, Michelle A. Rudek
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1309-1322 (2023)
Abstract Although DNA methyltransferase inhibitors (DNMTis), such as azacitidine and decitabine, are used extensively in the treatment of myelodysplastic syndromes and acute myeloid leukemia, there remain unanswered questions about DNMTi's mechanism
Externí odkaz:
https://doaj.org/article/2558cdc7ea7d4ba6b1738378115c452f
Autor:
Henry T. Hsueh, Renee Ti Chou, Usha Rai, Wathsala Liyanage, Yoo Chun Kim, Matthew B. Appell, Jahnavi Pejavar, Kirby T. Leo, Charlotte Davison, Patricia Kolodziejski, Ann Mozzer, HyeYoung Kwon, Maanasa Sista, Nicole M. Anders, Avelina Hemingway, Sri Vishnu Kiran Rompicharla, Malia Edwards, Ian Pitha, Justin Hanes, Michael P. Cummings, Laura M. Ensign
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Sustained drug delivery strategies have many potential benefits for treating a range of diseases, particularly chronic diseases that require treatment for years. For many chronic ocular diseases, patient adherence to eye drop dosing regimens
Externí odkaz:
https://doaj.org/article/7e5564fd12a045e4b4626040941ea3e5
Autor:
Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, Jaron Sanchez, Brooks Applewhite, Kathleen Jee, Monika Deshpande, Miguel Flores-Bellver, Ming-Wen Hu, Chuanyu Guo, Shaima Salman, Yousang Hwang, Nicole M. Anders, Michelle A. Rudek, Jiang Qian, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the e
Externí odkaz:
https://doaj.org/article/208f02b363f54dcab967e446a3a95992
Autor:
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson III, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and available therapies, including immunotherapies, are ineffective for many patients. HCC is characterized by intratumoral hypoxia, and increased expression of hypoxia-ind
Externí odkaz:
https://doaj.org/article/93de6172546f4b1dba403323cea12053
Autor:
Amanda B. Kagan, Blake S. Moses, Bryan T. Mott, Ganesha Rai, Nicole M. Anders, Michelle A. Rudek, Curt I. Civin
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Acute myeloid leukemia (AML) remains a devastating disease, with low cure rates despite intensive standard chemotherapy regimens. In the past decade, targeted antileukemic drugs have emerged from research efforts. Nevertheless, targeted therapies are
Externí odkaz:
https://doaj.org/article/2cf6566fed2a4ca3b0fec12ce23940fd
Autor:
Anirudh Sharma, Sanem Özayral, Julia S. Caserto, Rosemarie ten Cate, Nicole M. Anders, James D. Barnett, Sri Kamal Kandala, Elizabeth Henderson, Jacqueline Stewart, Eleni Liapi, Michelle A. Rudek, Nicolaas A.P. Franken, Arlene L. Oei, Preethi Korangath, Fred Bunz, Robert Ivkov
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 1, Pp 711-719 (2019)
Purpose: A proposed mechanism for the enhanced effectiveness of hyperthermia and doxorubicin (Dox) combinations is increased intracellular Dox concentrations resulting from heat-induced cell stress. The purpose of this study was to determine whether
Externí odkaz:
https://doaj.org/article/72bc18e9717f462c987190e81cae41c8
Autor:
Kunal S. Parikh, Revaz Omiadze, Aditya Josyula, Richard Shi, Nicole M. Anders, Ping He, Youseph Yazdi, Peter J. McDonnell, Laura M. Ensign, Justin Hanes
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 2, Pp n/a-n/a (2021)
Abstract Sutures are applied almost universally at the site of trauma or surgery, making them an ideal platform to modulate the local, postoperative biological response, and improve surgical outcomes. To date, the only globally marketed drug‐elutin
Externí odkaz:
https://doaj.org/article/235fc883c4f34ff9aef8f69d95776b36
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e