Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nicole M Sayles"'
Autor:
Nneka Southwell, Onorina Manzo, Sandra Bacman, Dazhi Zhao, Nicole M Sayles, Jalia Dash, Keigo Fujita, Marilena D’Aurelio, Annarita Di Lorenzo, Giovanni Manfredi, Hibiki Kawamata
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1352-1378 (2024)
Abstract Mutations in CHCHD10, a mitochondrial protein with undefined functions, are associated with autosomal dominant mitochondrial diseases. Chchd10 knock-in mice harboring a heterozygous S55L mutation (equivalent to human pathogenic S59L) develop
Externí odkaz:
https://doaj.org/article/06da78e884b74bbabfb6411ca3018288
Publikováno v:
eLife, Vol 6 (2017)
The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK block the proliferation of various cancer cell lines, and MELK knockdown has bee
Externí odkaz:
https://doaj.org/article/b99d40db238a4793959d3b76a7669da3
Autor:
Nicole M. Sayles, Jill S. Napierala, Josef Anrather, Nadège Diedhiou, Jixue Li, Marek Napierala, Hélène Puccio, Giovanni Manfredi
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/b108419737af43439a6188f425d2817c
Autor:
Nicole M. Sayles, Nneka Southwell, Kevin McAvoy, Kihwan Kim, Alba Pesini, Corey J. Anderson, Catarina Quinzii, Suzanne Cloonan, Hibiki Kawamata, Giovanni Manfredi
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110475- (2022)
Summary: Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of heart mitochondrial function activate the mitochondrial integrated stress response (ISRmt), a transcriptional program affecting cell metabolism, m
Externí odkaz:
https://doaj.org/article/5012e15c8bdc4baf984db05e7aaa986a
Autor:
Michael Notaras, Dilek Colak, Aiman Lodhi, Paul Collier, Hagen Tilgner, David W. Greening, Friederike Dündar, Nicole M. Sayles
Publikováno v:
Molecular Psychiatry. 27:1416-1434
Due to an inability to ethically access developing human brain tissue as well as identify prospective cases, early-arising neurodevelopmental and cell-specific signatures of Schizophrenia (Scz) have remained unknown and thus undefined. To overcome th
Autor:
Veronica Granatiero, Nicole M. Sayles, Angela M. Savino, Hibiki Kawamata, Csaba Konrad, Giovanni Manfredi, Michael G. Kharas
Publikováno v:
Autophagy. 17:4029-4042
ALS (amyotrophic lateral sclerosis), the most common motor neuron disease, causes muscle denervation and rapidly fatal paralysis. While motor neurons are the most affected cells in ALS, studies on the pathophysiology of the disease have highlighted t
Autor:
Nicole M. Sayles, Michael Notaras, Dilek Colak, Paul Collier, Aiman Lodhi, David W. Greening, Friederike Dündar, Hagen Tilgner
Due to an inability to ethically access developing human brain tissue as well as identify prospective cases, early-arising neurodevelopmental and cell-specific signatures of Schizophrenia (Scz) have remained unknown and thus undefined. To overcome th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d8a35289ba0a33bf9dc9c964f19da7
https://doi.org/10.1101/2021.06.10.447949
https://doi.org/10.1101/2021.06.10.447949
Autor:
Zuzana Storchova, Joan C. Smith, Anand Vasudevan, Jason M. Sheltzer, Dan Levy, Narendra Kumar Chunduri, Jude Kendall, Michael Wigler, Justin Leu, Nicole M. Sayles, Prasamit S. Baruah, Zihua Wang, Peter Andrews
Publikováno v:
Dev Cell
High levels of cancer aneuploidy are frequently associated with poor prognosis. To examine the relationship between aneuploidy and cancer progression, we analyzed a series of congenic cell lines that harbor single extra chromosomes. We found that acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109bee3c71258f7838dbf15b814d4b17
https://europepmc.org/articles/PMC7354079/
https://europepmc.org/articles/PMC7354079/
Autor:
Nicole M. Sayles, Rachel Babij, Teresa A. Milner, Robert N. Fetcho, Susan A. Antigua, Anjali M. Rajadhyaksha, Delaney K. Fischer, Charlotte C. Bavley, Conor Liston, Baila S. Hall, Alexander P. Walsh, Thomas L. Kash, Jonathan E. Hackett, Natalia V. De Marco García, Natalina H. Contoreggi, Caitlin E. Burgdorf
Publikováno v:
Molecular Psychiatry. 25:2201-2202
Autor:
Anand Vasudevan, Prasamit S. Baruah, Joan C. Smith, Zihua Wang, Nicole M. Sayles, Peter Andrews, Jude Kendall, Justin E. Leu, Narendra Kumar Chunduri, Dan Levy, Michael Wigler, Zuzana Storchová, Jason M. Sheltzer
Most human tumors display chromosome-scale copy number alterations, and high levels of aneuploidy are frequently associated with advanced disease and poor patient prognosis. To examine the relationship between aneuploidy and cancer progression, we ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd16f3e4f7db3c9401bccc84a9ac83b