Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

Autor: D W James Keenan, Alistair I Roy, Ronan McMullan, Ashley Agus, Niall Anderson, Gert Boschman, Christopher Bassford, Stephen E Wright, Jonathan Scott, Anthony J. Rostron, A. John Simpson, Nicole M Robin, Cecilia O'Kane, Vanessa Linnett, Simon Baudouin, Ingeborg Welters, Jonathan Hulme, Susan A Bowett, Glenn Phair, Lydia M Emerson, Daniel F. McAuley, A Joy Allen, Julian Sonksen, Bronagh Blackwood, Paul Dark, Ross L Paterson, Kallirroi Kefala, Stephen Bonner, Gavin D. Perkins, Bryan Yates, Tina Van Den Broeck, Jennie Parker, Shondipon Laha, Timothy S. Walsh, Craig Spencer, Thomas P Hellyer, Suveer Singh, Jonathan Bannard-Smith, Andrew Conway Morris

Publikováno v: LANCET RESPIRATORY MEDICINE
Hellyer, T P, Mcauley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, Mcmullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, D J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(19)30367-4
Ann Transl Med
Hellyer, T P, McAuley, D, Walsh, T S, Anderson, N H, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C, Baudouin, S V, Paterson, R W, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N, Welters, I, Bassford, C, Yates, B, Spencer, C, Laha, S, Hulme, J, Bonner, S, Linnett, V C, Sonksen, J, van den Broeck, T, Boschman, G, Keenan, J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2019, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182 . https://doi.org/10.1016/S2213-2600(19)30367-4
Hellyer, T P, McAuley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, DW J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182-191 . https://doi.org/10.1016/S2213-2600(19)30367-4

Background: Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0819679fdb81603ef968776dfb2fb3b4
http://hdl.handle.net/10044/1/82700

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia

Autor: Niall Anderson, Ian Dimmick, Suveer Singh, Simon Baudouin, Stephen E Wright, Emma Browne, Daniel F. McAuley, Thomas P Hellyer, Nicole M Robin, John Widdrington, I. F. Laurenson, Andrew Conway Morris, Craig Spencer, Shondipon Laha, Timothy S. Walsh, Frans Nauwelaers, A. John Simpson, Jonathan Scott, Savita Gossain, Sarah Wiscombe, Gavin D. Perkins, Melinda Jeffels, Cecilia O'Kane, Kate Gould, Paul Dark, James G. Macfarlane, Alistair I Roy, Ronan McMullan, Marie-Hélène Ruchaud-Sparagano, Kallirroi Kefala

Publikováno v: Hellyer, T P, Conway Morris, A, McAuley, D F, Walsh, T S, Anderson, N H, Singh, S, Dark, P, Roy, A I, Baudouin, S V, Wright, S E, Perkins, G D, Kefala, K, Jeffels, M, McMullan, R, O'Kane, C M, Spencer, C, Laha, S, Robin, N, Gossain, S, Gould, K, Ruchaud-Sparagano, M-H, Scott, J, Browne, E M, MacFarlane, J G, Wiscombe, S, Widdrington, J D, Dimmick, I, Laurenson, I F, Nauwelaers, F & Simpson, A J 2015, ' Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia ', Thorax, vol. 70, no. 1, pp. 41-47 . https://doi.org/10.1136/thoraxjnl-2014-205766

Background: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a110c92adc8abf9c19a9489bae9d28b
https://www.repository.cam.ac.uk/handle/1810/307336