Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nicole M Littman"'
Autor:
Barbara J. Brandhuber, George T. Topalov, Michele Callejo, Matthew Martinson, Nikole Randolph, Susan L. Gloor, Ellen R. Laird, Brad Newhouse, Mike Welch, Joseph P. Lyssikatos, Joshua D. Hansen, Jonas Grina, Rich Woessner, Alan G. Olivero, Guy Vigers, Nicole M Littman, Tony Morales
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4692-4695
Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01679be6189825d6dd1ca0c8f7d6aab9
https://doi.org/10.1016/j.bmcl.2008.07.002
https://doi.org/10.1016/j.bmcl.2008.07.002
Autor:
Matthew Martinson, George T. Topalov, Michele Callejo, Mike Welch, Nikole Randolph, Rich Woessner, Joseph P. Lyssikatos, Ellen R. Laird, Guy Vigers, Sarah Galbraith, Barbara J. Brandhuber, Jonas Grina, Joshua D. Hansen, Brad Newhouse, Nicole M Littman, Alan G. Olivero, Tony Morales
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d2ef9017c0890fcfd275c77fdaaee5
https://pubmed.ncbi.nlm.nih.gov/21536432
https://pubmed.ncbi.nlm.nih.gov/21536432