Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicole L. Solimini"'
Autor:
Paul L. Klarenbeek, David A. Hafler, Katrijn Verhaeghen, Nicole L. Solimini, George M. Church, Robert M. Plenge, Geert A. Martens, Peter A. Nigrovic, Philip L. De Jager, Ilse Weets, Stephen J. Elledge, Luis Querol, George Xu, Uri Laserson, Kevin C. O’Connor, H. Benjamin Larman
Publikováno v:
Journal of autoimmunity, 43, 1-9. Academic Press Inc.
Autoimmune disease results from a loss of tolerance to self-antigens in genetically susceptible individuals. Completely understanding this process requires that targeted antigens be identified, and so a number of techniques have been developed to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ce266b067b00f9b7da7aa58602151b
https://doi.org/10.1016/j.jaut.2013.01.013
https://doi.org/10.1016/j.jaut.2013.01.013
Autor:
Nicole L. Solimini, Michael R. Schlabach, Qikai Xu, Anna E. Burrows, Rameen Beroukhim, Ji Luo, Andrea L. Bredemeyer, Mamie Z. Li, Matthew Meyerson, Anthony Anselmo, Anthony C. Liang, Craig H. Mermel, Stephen J. Elledge
Publikováno v:
Science. 337:104-109
Cancer Gene Islands Human tumors are riddled with genomic alterations that rearrange, remove, amplify, or otherwise disrupt a wide spectrum of genes, and a key challenge is identifying which of these alterations are causally involved in tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fd47ee56fa919d993b965bce007b01
https://doi.org/10.1126/science.1219580
https://doi.org/10.1126/science.1219580
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f333634ece8665702ff6849596ee06
https://doi.org/10.1096/fasebj.27.1_supplement.451.1
https://doi.org/10.1096/fasebj.27.1_supplement.451.1
Autor:
Qikai Xu, Kwok-Kin Wong, Mamie Z. Li, Anthony C. Liang, Nicole L. Solimini, Teresa Davoli, Natalya N. Pavlova, Stephen J. Elledge, Chunxiao Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Cancer develops through genetic and epigenetic alterations that allow unrestrained proliferation and increased survival. Using a genetic RNAi screen, we previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dbf19ab641882a50cd0ce529f72ff0
https://doi.org/10.1073/pnas.1221385110
https://doi.org/10.1073/pnas.1221385110
Autor:
Devin Worster, Joan S. Brugge, Bjorn Millard, Gordon B. Mills, John G. Albeck, Eric S. Lightcap, Nicole L. Solimini, Tobias Schmelzle
Publikováno v:
Science Signaling. 5
Epithelial cells respond to growth factors including epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), and insulin. Using high-content immunofluorescence microscopy, we quantitated differences in signaling networks downstream of EG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e635845d66942e41627d47b12b3296c4
https://doi.org/10.1126/scisignal.2001986
https://doi.org/10.1126/scisignal.2001986
Autor:
Tingting Sun, Mamie Z. Li, Earlene M. Schmitt, Zachary C. Hartman, Peng Yu, Nicole L. Solimini, Bing Yu, Rachel Schiff, Stephen J. Elledge, Rocio Dominguez-Vidana, Tiffany Y.T. Hsu, Ido Golding, Ji Luo, Jessica D. Kessler, Anthony C. Liang, Chad A. Shaw, Michael R. Schlabach, Kristen L. Meerbrey, Kristopher T. Kahle, Thomas F. Westbrook, C. Kent Osborne, Susan G. Hilsenbeck, Ronald J. Bernardi, Samuel O. Skinner, Mitchell Rao, Chad J. Creighton, Qikai Xu
Publikováno v:
Science (New York, N.Y.). 335(6066)
Taking the Myc Despite nearly 30 years of research into the mechanisms by which Myc oncogene dysregulation contributes to tumorigenesis, there are still no effective therapies that inhibit Myc activity. Kessler et al. (p. 348 , published online 8 Dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c63d9b47513a219f0054ce3cdffbc
https://pubmed.ncbi.nlm.nih.gov/22267799
https://pubmed.ncbi.nlm.nih.gov/22267799
Autor:
Mamie Z. Li, Zhenming Zhao, Stephen J. Elledge, H. Benjamin Larman, Santosh Kesari, Uri Laserson, Nicole L. Solimini, Emily M LeProust, George M. Church, M. Angelica Martinez Gakidis, Alberto Ciccia
Publikováno v:
Nature biotechnology
Immune responses targeting self-proteins (autoantigens) can lead to a variety of autoimmune diseases. Identification of these antigens is important for both diagnostic and therapeutic reasons. However, current approaches to characterize autoantigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a614e604c0e49c5b73fc72b58d5b3173
https://pubmed.ncbi.nlm.nih.gov/21654669
https://pubmed.ncbi.nlm.nih.gov/21654669
Autor:
J. Wade Harper, Thomas F. Westbrook, Jennifer A. Hackett, Anthony C. Liang, Agata Smogorzewska, Nicole L. Solimini, Mamie Z. Li, Stephen J. Elledge, Mathew E. Sowa, Qikai Xu, Zhenming Zhao, Gregory J. Hannon, Michael R. Schlabach, Kenneth Chang, Xiaolu L. Ang, Guang Hu, Ji Luo
Publikováno v:
Science (New York, N.Y.). 319(5863)
Retroviral short hairpin RNA (shRNA)–mediated genetic screens in mammalian cells are powerful tools for discovering loss-of-function phenotypes. We describe a highly parallel multiplex methodology for screening large pools of shRNAs using half-hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad75bdd4e5d0de95c47a4c8fb958731
https://pubmed.ncbi.nlm.nih.gov/18239126
https://pubmed.ncbi.nlm.nih.gov/18239126
Autor:
Bryan A. Ballif, Kristen E. Hurov, Corey E. Bakalarski, Agata Smogorzewska, Ji Luo, Yaniv Lerenthal, Yosef Shiloh, E. Robert McDonald, Nicole L. Solimini, Shuhei Matsuoka, Zhenming Zhao, Stephen J. Elledge, Steven P. Gygi
Publikováno v:
Science (New York, N.Y.). 316(5828)
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee633395853a3909e7001c5960619ac
https://pubmed.ncbi.nlm.nih.gov/17525326
https://pubmed.ncbi.nlm.nih.gov/17525326
Autor:
Jason S. Carroll, Joan S. Brugge, Arnaud Mailleux, Michael Overholtzer, O. P. Veiby, Nicole L. Solimini, Tobias Schmelzle, Eric S. Lightcap
The formation of a lumen in three-dimensional mammary epithelial acinar structures in vitro involves selective apoptosis of centrally localized cells that lack matrix attachment. Similarly, apoptosis is induced by forced detachment of mammary epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39183e06fca86b537c06b412fde7e165
https://europepmc.org/articles/PMC1820662/
https://europepmc.org/articles/PMC1820662/
