Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Nicole L. Moore"'
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Akademický článek
The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities
Autor: Josephine A. Hinneh, Joanna L. Gillis, Nicole L. Moore, Lisa M. Butler, Margaret M. Centenera
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Receptor for hyaluronic acid-mediated motility (RHAMM) is a cell surface receptor for hyaluronic acid that is critical for cell migration and a cell cycle protein involved in microtubule assembly and stability. These functions of RHAMM are required f
Externí odkaz: https://doaj.org/article/7407ac07a6cc44faaaa40e7fab0f5b04
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4
Anti-proliferative transcriptional effects of medroxyprogesterone acetate in estrogen receptor positive breast cancer cells are predominantly mediated by the progesterone receptor
Autor: Nicole L. Moore, Theresa E. Hickey, Wayne D. Tilley, Adrienne R. Hanson, Esmaeil Ebrahimie
Publikováno v: The Journal of steroid biochemistry and molecular biology. 199
Medroxyprogesterone acetate (MPA) is a first generation progestin that has been in clinical use for various hormonal conditions in women since the 1960s. Although developed as a progesterone receptor (PR) agonist, MPA also has strong binding affinity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf503335b7dc0d55f2e705da6b998c7
https://pubmed.ncbi.nlm.nih.gov/31805393
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5
Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors
Autor: Elisa J. Cops, Stephen N. Birrell, Wayne D. Tilley, Tina Bianco-Miotto, Lisa M. Butler, Nicole L. Moore, Christine L. Clarke
Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 110:236-243
Androgen signaling, mediated by the androgen receptor (AR), is a critical factor influencing growth of normal and malignant breast cells. Given the increasing use of exogenous androgens in women, a better understanding of androgen action in the breas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5f8d25e475e89c57b48b193eb81102
https://doi.org/10.1016/j.jsbmb.2007.10.014
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6
Vitamin D Status of Patients Admitted to a Hospital Rehabilitation Unit
Autor: C George Kevorkian, Nicole L. Moore, Gary M. Kiebzak, Bruce W. Hollis, Shana Margolis
Publikováno v: American Journal of Physical Medicine & Rehabilitation. 86:435-445
The primary objective was to determine the association between vitamin D status, baseline function, and short-term inpatient rehabilitation progress.This was a prospective convenience sampling of 100 patients in a tertiary general hospital rehabilita
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a34eee470e892e5c12493003e75a034
https://doi.org/10.1097/phm.0b013e31805b7e20
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7
Cyclins, cyclin dependent kinases, and regulation of steroid receptor action
Autor: Nancy L. Weigel, Nicole L. Moore
Publikováno v: Molecular and Cellular Endocrinology. :157-161
Steroid receptors (SR), which are ligand activated transcription factors, and their coactivators are phosphoproteins whose activities are regulated by cell signaling pathways. Many of the identified phosphorylation sites in these proteins contain Ser
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209f2f67710c3e1b67d7291356d70928
https://doi.org/10.1016/j.mce.2006.12.013
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8
Decreased Androgen Receptor Levels and Receptor Function in Breast Cancer Contribute to the Failure of Response to Medroxyprogesterone Acetate
Autor: Nicole L. Moore, Wayne D. Tilley, Jacqueline M. Bentel, Miao Yang, Henry A. Simila, Carmella Ricciardelli, David J. Horsfall, Amelia A. Peters, Stephen N. Birrell, Elisa J. Cops, Tina Bianco-Miotto, Grant Buchanan, Jonathan M. Harris, Lisa M. Butler, Katrina Ramsay
Publikováno v: Cancer Research. 65:8487-8496
Previously, we reported that androgen receptor (AR), but not estrogen receptor (ER) or progesterone receptor (PR), is predictive of response to the synthetic progestin, medroxyprogesterone acetate (MPA), in a cohort of 83 patients with metastatic bre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29f4a31f39a74a6aaa35bfcef730c74
https://doi.org/10.1158/0008-5472.can-04-3077
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9
Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells
Autor: Dean P. Edwards, Nancy L. Weigel, Nicole L. Moore
Publikováno v: The Journal of steroid biochemistry and molecular biology.
A role for the cell cycle protein cyclin A2 in regulating progesterone receptor (PR) activity is emerging. This study investigates the role of cyclin A2 in regulating endogenous PR activity in T47D breast cancer cells by depleting cyclin A2 expressio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdda6bdd5a84f5169a96a250e01038d
https://pubmed.ncbi.nlm.nih.gov/25220500
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10
Mutations at the Boundary of the Hinge and Ligand Binding Domain of the Androgen Receptor Confer Increased Transactivation Function
Autor: Miao Yang, Nicole L. Moore, David J. Horsfall, Jacqueline M. Bentel, Wayne D. Tilley, Norman M. Greenberg, Grant Buchanan, Robert J. Matusik, Jonathan M. Harris, Hyun S. Nahm, Guangzhou Han, Villis R. Marshall
Publikováno v: Molecular Endocrinology. 15:46-56
The androgen receptor (AR), a member of the steroid receptor superfamily of nuclear transcription factors, mediates androgen signaling in diverse target tissues. Here we report AR gene mutations identified in human prostate cancer and the autochthono
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc294b4423a45b9c5645fadce8f73d
https://doi.org/10.1210/mend.15.1.0581
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