Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole L. McIntosh"'
Autor:
Nicole L. McIntosh, Geoffrey Y. Berguig, Omair A. Karim, Christa L. Cortesio, Rolando De Angelis, Ayesha A. Khan, Daniel Gold, John A. Maga, Vikas S. Bhat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Adeno associated virus (AAV) capsids are a leading modality for in vivo gene delivery. Complete and precise characterization of capsid particles, including capsid and vector genome concentration, is necessary to safely and efficaciously dose
Externí odkaz:
https://doaj.org/article/c3c8db3276f844adbcb7cbaf0943c311
Autor:
Nicole L. McIntosh, Geoffrey Y. Berguig, Omair A. Karim, Christa L. Cortesio, Rolando De Angelis, Ayesha A. Khan, Daniel Gold, John A. Maga, Vikas S. Bhat
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/14f2ad347d0843cc8e440c96e095713c
Autor:
Britta Handyside, Ashrafali Mohamed Ismail, Lening Zhang, Bridget Yates, Lin Xie, Choong-Ryoul Sihn, Ryan Murphy, Taren Bouwman, Chan Kyu Kim, Rolando De Angelis, Omair A. Karim, Nicole L. McIntosh, Michael Xavier Doss, Shilpa Shroff, Erno Pungor, Vikas S. Bhat, Sherry Bullens, Stuart Bunting, Sylvia Fong
Publikováno v:
Molecular Therapy. 30:3570-3586
Recombinant adeno-associated virus (rAAV) vectors are often produced in HEK293 or Spodoptera frugiperda (Sf)-based cell lines. We compared expression profiles of "oversized" (∼5,000 bp) and "standard-sized" (4,600 bp) rAAV5-human α1-antitrypsin (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9747859dff1c27f1a3f01d6c5cbf29f9
https://doi.org/10.1016/j.ymthe.2022.11.001
https://doi.org/10.1016/j.ymthe.2022.11.001
Autor:
Anthony J. Sinskey, Scott R. Manalis, Vincent Agache, Iris E. Hwang, Jacqueline Wolfrum, Sha Sha, Richard D. Braatz, Wade Wang, Omair A. Karim, Nicole L. McIntosh, Paul W. Barone, Stacy L. Springs, Georgios Katsikis, Vikas Bhat, Bartlomiej J. Blus
Publikováno v:
Nano Letters. 22:1511-1517
Quantifying the composition of viral vectors used in vaccine development and gene therapy is critical for assessing their functionality. Adeno-Associated Virus (AAV) vectors, which are the most widely used viral vectors for in-vivo gene therapy, are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9018352a514a6cd67826b34fd8a90b4d
https://doi.org/10.1021/acs.nanolett.1c04092
https://doi.org/10.1021/acs.nanolett.1c04092
Autor:
Tyler A. Johnson, David Coppage, Jiajiu Shaw, Phillip Crews, Joseph Media, Marcos A. Ogarrio, Frederick A. Valeriote, Erin P. McCauley, Joseph D. Morris, Lauren N Persi, Mani Maheshwari, Taylor C Garcia, Nicole L. McIntosh, Colon V. Cook
Publikováno v:
ACS Medicinal Chemistry Letters. 11:108-113
Reinvestigation of mycothiazole (1) revealed picomolar potency (IC50 = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α]D data indicating Vanuatu specimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25064717cf5b9545371be28eab12d710
https://doi.org/10.1021/acsmedchemlett.9b00302
https://doi.org/10.1021/acsmedchemlett.9b00302
Autor:
John A Maga, Vikas Bhat, Geoffrey Y. Berguig, Ayesha A Khan, Nicole L. McIntosh, Daniel Solomon Gold, Rolando De Angelis, Christa L Cortesio, Omair A. Karim
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Adeno associated virus (AAV) capsids are a leading modality for in vivo gene delivery. Complete and precise characterization of capsid particles, including capsid and vector genome concentration, is necessary to safely and efficaciously dose patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13242f126d8f9301a67079f8371ca11e
https://pubmed.ncbi.nlm.nih.gov/36396936
https://pubmed.ncbi.nlm.nih.gov/36396936
Autor:
Tyler A, Johnson, Joseph D, Morris, David A, Coppage, Colon V, Cook, Lauren N, Persi, Marcos A, Ogarrio, Taylor C, Garcia, Nicole L, McIntosh, Erin P, McCauley, Joseph, Media, Mani, Maheshwari, Frederick A, Valeriote, Jiajiu, Shaw, Phillip, Crews
Publikováno v:
ACS Med Chem Lett
[Image: see text] Reinvestigation of mycothiazole (1) revealed picomolar potency (IC(50) = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α](D) data indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b1a8892b1d427a8ed885846904f2b15
https://pubmed.ncbi.nlm.nih.gov/32071675
https://pubmed.ncbi.nlm.nih.gov/32071675
Autor:
Eptisam Lambu, Philip Crews, Li He, Jennifer L. Whistler, Allison Coker, Fei Li, Madeline Fewerda, Laura Milan-Lobo, Nicole L. McIntosh, Tyler A. Johnson
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f80b04c0d3176866cc9b4c7282024eb
https://doi.org/10.1096/fasebj.2018.32.1_supplement.554.1
https://doi.org/10.1096/fasebj.2018.32.1_supplement.554.1
Autor:
David Coppage, Karen Tenney, Phillip Crews, Frederick A. Valeriote, Colon V. Cook, Tyler A. Johnson, Nicole L. McIntosh, Marcos A. Ogarrio
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96311270b22c5a00f57f457f7affe1b0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.836.12
https://doi.org/10.1096/fasebj.2018.32.1_supplement.836.12