Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicole L. Grant"'
Autor:
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O’Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Despite the extensive research on CD4 T cells within the context of Mycobacterium tuberculosis (Mtb) infections, few studies have focused on identifying and investigating the profile of Mtb-specific T cells within lung granulomas. To facilit
Externí odkaz:
https://doaj.org/article/0bd7932b650b4c48833d648c0ad5e9a1
Autor:
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110826- (2022)
Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host c
Externí odkaz:
https://doaj.org/article/27d79ee8867c4472a720d0e7466b5302
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/bf3567b2577c4e5a9d254f761658596f
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines and treatment require a 2better understanding of the immune response to infection with Mycobacterium tuberculosis (Mtb). In many infectious diseases, pathogen-
Externí odkaz:
https://doaj.org/article/18bc1f958e4442d3b25681c8a9dfda80
Autor:
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O’Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Despite the extensive research on CD4 T cells within the context ofMycobacterium tuberculosis(Mtb) infection, few studies have focused on identifying and investigating the profile of Mtb-specific T cells within lung granulomas. To facilitate identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec50c43a2ce27ce77b34835be53ffcd3
https://doi.org/10.1101/2022.11.30.518638
https://doi.org/10.1101/2022.11.30.518638
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn
SUMMARYMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff54b069c7bcba7db81354228a5d2c7
https://doi.org/10.1101/2022.01.25.477732
https://doi.org/10.1101/2022.01.25.477732
Autor:
Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Pauline Maiello, Alexander G. White, Caylin G. Winchell, Sarah K. Nyquist, Sharie Keanne C. Ganchua, Amy Myers, Kush V. Patel, Cassaundra L. Ameel, Catherine T. Cochran, Samira Ibrahim, Jaime A. Tomko, Lonnie James Frye, Jacob M. Rosenberg, Angela Shih, Michael Chao, Edwin Klein, Charles A. Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T. Mattila, Rajhmun Madansein, J. Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M. Behar, Bryan Bryson, JoAnne L. Flynn, Sarah M. Fortune, Alex K. Shalek
Publikováno v:
Immunity. 55:827-846.e10
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial c
Autor:
Louis R. Joslyn, Nicole L. Grant, Denise E. Kirschner, J. Russ Butler, JoAnne L. Flynn, Caleb Weissman, Marissa Renardy
Publikováno v:
Complex Systems and Computational Biology Approaches to Acute Inflammation ISBN: 9783030565091
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), kills more individuals worldwide per year than any other infectious agent. As the hallmark of TB, lung granulomas are complex structures composed of immune cells that interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7642e7fd6a65c8b79f8dce715f80077f
https://doi.org/10.1007/978-3-030-56510-7_15
https://doi.org/10.1007/978-3-030-56510-7_15
Autor:
Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Pauline Maiello, Alexander G. White, Caylin G. Winchell, Sarah K. Nyquist, Sharie Keanne C. Ganchua, Amy Myers, Kush V Patel, Cassaundra L. Ameel, Catherine T. Cochran, Samira Ibrahim, Jaime A Tomko, Lonnie James Frye, Jacob M. Rosenberg, Angela Shih, Michael Chao, Charles A. Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T. Mattila, Rajhmun Madansein, J. Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M. Behar, Bryan Bryson, JoAnne L Flynn, Sarah M. Fortune, Alex K. Shalek
Mycobacterium tuberculosis lung infection results in a complex multicellular structure, the granuloma. In some granulomas, immune activity promotes bacterial clearance; in others, bacteria persist and grow. We identified correlates of bacterial contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7560139895ed4573b1d19bd67d012bd6
https://doi.org/10.1101/2020.10.24.352492
https://doi.org/10.1101/2020.10.24.352492