Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicole Kerry"'
Publikováno v:
The Journal of Immunology. 173:3186-3192
Folate is required for one-carbon transfer reactions and the formation of purines and pyrimidines for DNA and RNA synthesis. Deficiency of folate can lead to many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth def
Autor:
Catherine Rice-Evans, Nicole Kerry
Publikováno v:
Journal of Neurochemistry. 73:247-253
The interaction between peroxynitrite and dopamine and the inhibition of this reaction by plant-derived antioxidants have been investigated. Peroxynitrite promoted the oxidation of dopamine to 6-hydroxyindole-5-one as characterised by HPLC and photod
Autor:
Nicole Kerry, Mavis Abbey
Publikováno v:
Atherosclerosis. 135:93-102
The oxidative modification of low density lipoproteins (LDL) has been implicated in the development of atherosclerosis. This study examined the effect of red wine, ethanol and red wine stripped of phenols on copper-mediated and azo-initiated LDL oxid
Publikováno v:
Biochemical Pharmacology. 45:833-839
The O-demethylation of dextromethorphan (DM) to dextrorphan (DR) is catalysed by the polymorphic CYP2D6 (cytochrome P4502D6) isozyme in man. DM is commonly used as a probe for phenotyping subjects as either poor or extensive metabolizers for the debr
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison
Autor:
Chantal Courtemanche, Bernice Y. Ng, Bruce N. Ames, Arnold C. Huang, Nicole Kerry, Ilan Elson-Schwab
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(1)
DNA double-strand breaks, the most serious DNA lesion caused by ionizing radiation, are also caused by several vitamin or mineral deficiencies, such as for folate. Primary human lymphocytes were either irradiated or cultured at different levels of fo
Autor:
Nicole Kerry, Mavis Abbey
Publikováno v:
Atherosclerosis. 140(2)
Oxidation of low density lipoprotein (LDL) is implicated in the development of atherosclerosis and dietary antioxidants may provide a useful therapy in the prevention of LDL oxidation and atheroma development. The aim of these experiments was to inve
Publikováno v:
British journal of clinical pharmacology. 38(3)
1. The enzyme kinetics of dextromethorphan O-demethylation in liver microsomes from three extensive metabolisers (EM) with respect to CYP2D6 indicated high (Km1 2.2-9.4 microM) and low (Km2 55.5-307.3 microM) affinity sites whereas microsomes from tw
Autor:
Catherine Rice-Evans, Nicole Kerry
Publikováno v:
FEBS Letters. (3):167-171
Nitration of phenolic compounds is a well-established mechanism on interaction with peroxynitrite. However, while nitration is the predominant reaction for monophenolic hydroxycinnamates, this does not take place with the catechol-containing hydroxyc