Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Nicole K. Paulk"'
Autor:
Prasad D. Trivedi, Chenghui Yu, Payel Chaudhuri, Evan J. Johnson, Tina Caton, Laura Adamson, Barry J. Byrne, Nicole K. Paulk, Nathalie Clément
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 154-170 (2022)
Recent clinical successes have propelled recombinant adeno-associated virus vectors (rAAV) to the center stage for human gene therapy applications. However, the exploding demand for high titers of highly pure rAAV vectors for clinical applications an
Externí odkaz:
https://doaj.org/article/97b4dcff8c0649f8864f4a8556d6d176
Autor:
Neil G. Rumachik, Stacy A. Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis Thomas, Susan Stamnes, Kathleen Holt, Patrick Sinn, Andrew P. May, Nicole K. Paulk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 98-118 (2020)
Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human HEK293 cells and live baculovirus infection of Spodoptera frugiperda (Sf9) insect cells. Unexpl
Externí odkaz:
https://doaj.org/article/5bf725043a6b4f7f9442d02c1d0f7c87
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/0e0333f1ddf1421f80c4e6c8d8b1c964
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Progress in recombinant AAV gene therapy product and process development has advanced our understanding of the basic biology of this critical delivery vector. The discovery of rAAV capsid post-translational modifications (PTMs) has spurred interest i
Externí odkaz:
https://doaj.org/article/6b97b356396c4be885faf58cabe4ca20
Autor:
Nicole K. Paulk, Katja Pekrun, Gregory W. Charville, Katie Maguire-Nguyen, Michael N. Wosczyna, Jianpeng Xu, Yue Zhang, Leszek Lisowski, Bryan Yoo, Jose G. Vilches-Moure, Gordon K. Lee, Joseph B. Shrager, Thomas A. Rando, Mark A. Kay
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 144-155 (2018)
Skeletal muscle is ideal for passive vaccine administration as it is easily accessible by intramuscular injection. Recombinant adeno-associated virus (rAAV) vectors are in consideration for passive vaccination clinical trials for HIV and influenza. H
Externí odkaz:
https://doaj.org/article/ba3cc380d053477da8b6a626ff9c0d2b
Autor:
Ian P. Winters, Shin-Heng Chiou, Nicole K. Paulk, Christopher D. McFarland, Pranav V. Lalgudi, Rosanna K. Ma, Leszek Lisowski, Andrew J. Connolly, Dmitri A. Petrov, Mark A. Kay, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Genome editing technologies enable the rapid interrogation of genetic alterations. Here, the authors present a CRISPR/Cas9-based platform to simultaneously investigate multiple activating point mutations in de novo cancers in mice; and generate panel
Externí odkaz:
https://doaj.org/article/ec34a2e663bb4e9aa7d634750cb16aee
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Autor:
Nicole K. Paulk
Publikováno v:
Genetic Engineering & Biotechnology News. 40:14-16
Autor:
Michael Z. Lin, Namdoo Kim, Joseph C. Wu, Younghee Oh, Mark A. Kay, Julia H Cho, Yunhee Park, Lan Xiang Liu, Haodi Wu, Nicole K. Paulk
Publikováno v:
Nature chemical biology
Fluorescent indicators are used widely to visualize calcium dynamics downstream of membrane depolarization or G-protein-coupled receptor activation, but are poorly suited for non-invasive imaging in mammals. Here, we report a bright calcium-modulated
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Progress in recombinant AAV gene therapy product and process development has advanced our understanding of the basic biology of this critical delivery vector. The discovery of rAAV capsid post-translational modifications (PTMs) has spurred interest i