Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicole Jedinger"'
Autor:
Eva Roblegg, Simone Schrank, Johannes Khinast, Nicole Jedinger, Johannes M. Fischer, Karlheinz Breinhälter
Publikováno v:
AAPS PharmSciTech. 17:68-77
This study focused on the development of flexible (i.e., deformable) multiple-unit pellets that feature (i) a prolonged drug release, (ii) drug abuse deterrence, and (iii) a minimal risk of alcohol-induced dose dumping (ADD). Deformable pellets were
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 87:217-226
The concomitant intake of alcoholic beverages together with oral controlled-release opioid formulations poses a serious safety concern since alcohol has the potential to alter the release rate controlling mechanism of the dosage form which may result
Publikováno v:
International journal of pharmaceutics. 509(1-2)
In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion
Autor:
Johannes Khinast, Andrea Feichtinger, Eva Roblegg, Simone Schrank, Stefan Mohr, Nicole Jedinger
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92
The objective of the present study was to investigate interactions between alcohol and hot-melt extruded pellets and the resulting drug release behavior. The pellets were composed of vegetable calcium stearate as matrix carrier and paracetamol or cod