Výsledky vyhledávání - "Nicole J. Medeiros"

Akademický článek

In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.

Autor: Amanda L Miller, J Alex Pasternak, Nicole J Medeiros, Lauren K Nicastro, Sarah A Tursi, Elizabeth G Hansen, Ryan Krochak, Akosiererem S Sokaribo, Keith D MacKenzie, Melissa B Palmer, Dakoda J Herman, Nikole L Watson, Yi Zhang, Heather L Wilson, R Paul Wilson, Aaron P White, Çagla Tükel

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008591 (2020)

Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an extracellular, bacterial amyloid with cross beta-sheet structure can trigger inflammatory

Externí odkaz: https://doaj.org/article/1badb525e2964d4b81ab1e7a66ba92da

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Akademický článek

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

Autor: R Paul Wilson, Sarah A Tursi, Glenn J Rapsinski, Nicole J Medeiros, Long S Le, Kevin P Kotredes, Sajan Patel, Elisabetta Liverani, Shuang Sun, Wenhan Zhu, Laurie Kilpatrick, Sebastian E Winter, Ana M Gamero, Çagla Tükel

Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007745 (2019)

The mechanisms by which the gut luminal environment is disturbed by the immune system to foster pathogenic bacterial growth and survival remain incompletely understood. Here, we show that STAT2 dependent type I IFN signaling contributes to the inflam

Externí odkaz: https://doaj.org/article/648625e4182d42e88ea88a6f56d5c0a6

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Akademický článek

Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9.

Autor: Sarah A Tursi, Ernest Y Lee, Nicole J Medeiros, Michael H Lee, Lauren K Nicastro, Bettina Buttaro, Stefania Gallucci, Ronald Paul Wilson, Gerard C L Wong, Çagla Tükel

Publikováno v: PLoS Pathogens, Vol 13, Iss 4, p e1006315 (2017)

Bacterial biofilms are associated with numerous human infections. The predominant protein expressed in enteric biofilms is the amyloid curli, which forms highly immunogenic complexes with DNA. Infection with curli-expressing bacteria or systemic expo

Externí odkaz: https://doaj.org/article/ab1761a0ea1e4e6b805a725f50f361e1

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