Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicole J. Cooper"'
Autor:
Wolfgang Liedtke, Tobias Liebregts, B. Adam, Patrick A. Hughes, Nicole J. Cooper, Stuart M. Brierley, L. Ashley Blackshaw, Amanda J. Page, Gerald Holtmann
Publikováno v:
Gastroenterology. 134:2059-2069
Background & Aims: Although there are many candidates as molecular mechanotransducers, so far there has been no evidence for molecular specialization of visceral afferents. Here, we show that colonic afferents express a specific molecular transducer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b4e819570b93bd6b7d1591b5c9df74
https://doi.org/10.1053/j.gastro.2008.01.074
https://doi.org/10.1053/j.gastro.2008.01.074
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G1420-G1428
Nutrient-evoked gastrointestinal reflexes are likely initiated by specialized epithelial cells located in the small intestine that detect luminal stimuli and release mediators that activate vagal endings. The G-protein alpha-gustducin, a key signal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9ffd758c2b09e79486f8734d517b2c
https://doi.org/10.1152/ajpgi.00504.2006
https://doi.org/10.1152/ajpgi.00504.2006
Autor:
Tracey A. O'Donnell, Amanda J. Page, James A. Slattery, Nicole J. Cooper, L. Ashley Blackshaw, Richard L. Young
Publikováno v:
The Journal of Physiology. 563:809-819
The neuropeptide galanin is found in the central and peripheral nervous systems. It may have excitatory or inhibitory actions via three subtypes of G-protein-coupled receptor, and it modulates the mechanosensitivity of somatic sensory fibres. We aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a216c4fc96e7552386afc2968899b83
https://doi.org/10.1113/jphysiol.2004.075291
https://doi.org/10.1113/jphysiol.2004.075291
Autor:
Jan P. Mattsson, Mia Umaerus, Malin Hulander, Tracey A. O'Donnell, Amanda J. Page, Anders Lehmann, Nicole J. Cooper, Christopher M. Martin, Jonathan R. Coldwell, Richard L. Young, L. Ashley Blackshaw
Publikováno v:
Gastroenterology. 128:402-410
Background & Aims: Inhibitory G-protein-coupled receptors have demonstrated potential in treatment of gastroesophageal reflux disease (GERD) through actions on vagal afferent signaling. Metabotropic glutamate receptors (mGluR) belong to this receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab3e0ab3219d6eaeef3c543ed369ea7
https://doi.org/10.1053/j.gastro.2004.11.062
https://doi.org/10.1053/j.gastro.2004.11.062
Publikováno v:
Gastroenterology. 138(3)
Background & Aims During gastroesophageal reflux, transient lower esophageal sphincter relaxation and crural diaphragm (CD) inhibition occur concomitantly. Modifying vagus nerve control of transient lower esophageal sphincter relaxation is a major fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8895a11c08454e82147b490ab5d689bd
https://pubmed.ncbi.nlm.nih.gov/19732773
https://pubmed.ncbi.nlm.nih.gov/19732773
Publikováno v:
Neuropharmacology. 54(6)
Metabotropic glutamate receptors (mGluR) are classified into groups I (excitatory), II and III (inhibitory) mGluR. Activation of peripheral group III mGluR (mGluR4, mGluR6, mGluR7, mGluR8), particularly mGluR8, inhibits vagal afferent mechanosensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e46f1f8d3807213bdbbe1e61c62a24e
https://pubmed.ncbi.nlm.nih.gov/18371991
https://pubmed.ncbi.nlm.nih.gov/18371991
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 292(2)
Metabotropic glutamate receptors (mGluR) are classified into group I, II, and III mGluR. Group I (mGluR1, mGluR5) are excitatory, whereas group II and III are inhibitory. mGluR5 antagonism potently reduces triggering of transient lower esophageal sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6dad310edf4bdd708483caa2343399
https://pubmed.ncbi.nlm.nih.gov/17053158
https://pubmed.ncbi.nlm.nih.gov/17053158
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 281(6)
GABAB-receptor (GABABR) agonists reduce transient lower esophageal sphincter relaxation (TLESR) and reflux episodes through an action on vagal pathways. In this study, we determined whether GABABR are expressed on vagal afferent neurones and whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ad279387350458d3547ea8c84130cb
https://pubmed.ncbi.nlm.nih.gov/11705755
https://pubmed.ncbi.nlm.nih.gov/11705755
Autor:
Christopher M. Martin, Patrick A. Hughes, Andrea M. Harrington, Nicole J. Cooper, B. Adam, David P. Corey, Tracey A. O'Donnell, Grigori Y. Rychkov, L. Ashley Blackshaw, Tobias Liebregts, Kelvin Y. Kwan, Gerald Holtmann, Stuart M. Brierley, Amanda J. Page
Publikováno v:
Gastroenterology. 137:2084-2095.e3
BACKGROUND & AIMS: The transient receptor potential (TRP) channel family includes transducers of mechanical and chemical stimuli for visceral sensory neurons. TRP ankyrin 1 (TRPA1) is implicated in inflammatory pain; it interacts with G-protein-coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366558a6778e2307084c40410fc2abf8
https://doi.org/10.1053/j.gastro.2009.07.048
https://doi.org/10.1053/j.gastro.2009.07.048
Publikováno v:
Gastroenterology. 134:A-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6ffb002ef524b72b633fded1430031
https://doi.org/10.1016/s0016-5085(08)60348-0
https://doi.org/10.1016/s0016-5085(08)60348-0