Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicole J Lambert"'
Autor:
Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
Publikováno v:
eLife, Vol 3 (2014)
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated
Externí odkaz:
https://doaj.org/article/1bcc618553ce4884a9566906671808ea
Publikováno v:
PLoS Biology, Vol 10, Iss 1, p e1001229 (2012)
Thousands of human genes contain introns ending in NAGNAG (N any nucleotide), where both NAGs can function as 3' splice sites, yielding isoforms that differ by inclusion/exclusion of three bases. However, few models exist for how such splicing might
Externí odkaz:
https://doaj.org/article/c501e51f9f154b05b58855d6473b0147
Autor:
Anne E. Conway, Eric L. Van Nostrand, Gabriel A. Pratt, Stefan Aigner, Melissa L. Wilbert, Balaji Sundararaman, Peter Freese, Nicole J. Lambert, Shashank Sathe, Tiffany Y. Liang, Anthony Essex, Severine Landais, Christopher B. Burge, D. Leanne Jones, Gene W. Yeo
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 666-679 (2016)
Human pluripotent stem cells (hPSCs) require precise control of post-transcriptional RNA networks to maintain proliferation and survival. Using enhanced UV crosslinking and immunoprecipitation (eCLIP), we identify RNA targets of the IMP/IGF2BP family
Externí odkaz:
https://doaj.org/article/b657293d7277411a89c514e56c42b038
Autor:
Gabriel A. Pratt, Shashank Sathe, Neal A.L. Cody, Ruth Wang, Xiaofeng Wang, Peter Freese, Keri E. Garcia, Ashley L. Louie, Eric Lécuyer, Cassandra Bazile, Xintao Wei, Steven M. Blue, Rebecca Stanton, Myles Hochman, Daniel Dominguez, Balaji Sundararaman, Eric L. Van Nostrand, Michael O. Duff, Jia-Yu Chen, Nicole J. Lambert, Amanda Su, Julie Bergalet, Stefan Aigner, Tsultrim Palden, Ines Rabano, Xiang-Dong Fu, Hairi Li, Brenton R. Graveley, Chelsea Gelboin-Burkhart, Lijun Zhan, Bing Zhou, Gene W. Yeo, Christopher B. Burge, Thai B. Nguyen, Rui Xiao, Michael P. McGurk, Louis Philip Benoit Bouvrette, Brian A. Yee, Sara Olson
Publikováno v:
Nature, vol 583, iss 7818
Nature
Nature
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cdaacf41c6d6a57cdabc5d98c5fbe7
https://doi.org/10.1038/s41586-020-2077-3
https://doi.org/10.1038/s41586-020-2077-3
Autor:
Nicole J. Lambert, Ken Nesmith, Haluk Tezcan, Becky Wong, Andrew M. Davis, Ayse Tezcan, Young Kwang Chae, Neil Peterman, Michael S. Oh, Wade T. Iams, Timothy R. Wilson, Abhik Shah, Robert W. Lentz, Jason Close, Rohith Srivas, Haleigh Wood, David Chan, Alex Robertson, Peter George
Publikováno v:
Mol Cancer Ther
Treatment response assessment for patients with advanced solid tumors is complex and existing methods require greater precision. Current guidelines rely on imaging, which has known limitations, including the time required to show a deterministic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bafbcdaa220a134c176d6f50262322
https://europepmc.org/articles/PMC8142024/
https://europepmc.org/articles/PMC8142024/
Autor:
Brian A. Yee, Myles Hochman, Gabriel A. Pratt, Julie Bergalet, Sara Olson, Thai B. Nguyen, Brenton R. Graveley, Chelsea Gelboin-Burkhart, Jia-Yu Chen, Ashley L. Louie, Christopher B. Burge, Nicole J. Lambert, Keri E. Garcia, Eric L. Van Nostrand, Balaji Sundararaman, Tsultrim Palden, Bing Zhou, Louis Philip Benoit Bouvrette, Steven M. Blue, Xiaofeng Wang, Rui Xiao, Neal A.L. Cody, Lijun Zhan, Stefan Aigner, Xiang-Dong Fu, Michael O. Duff, Ines Rabano, Eric Lécuyer, Shashank Sathe, Michael P. McGurk, Gene W. Yeo, Cassandra Bazile, Rebecca Stanton, Ruth Wang, Peter Freese, Daniel Dominguez, Xintao Wei, Hairi Li, Amanda Su
Publikováno v:
Nature
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03067-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d71199f2c6b89865f97657d825f15bf
https://doi.org/10.1038/s41586-020-03067-w
https://doi.org/10.1038/s41586-020-03067-w
Autor:
Michael S. Oh, Robert W. Lentz, Andrew M. Davis, Young Kwang Chae, Neil Peterman, Haluk Tezcan, Alex Robertson, Rohith Srivas, David C. Chan, Ayse Tezcan, Abhik Shah, Nicole J. Lambert
Publikováno v:
Cancer Research. 80:P5-01
Background: Liquid biopsies have potential clinical utility as dynamic biomarkers for treatment response in advanced breast cancer. We evaluated a plasma-only assay to track serial changes in WG cfDNA to identify disease progression prior to routine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c637047772d38b4ec30bd7533f6ef175
https://doi.org/10.1158/1538-7445.sabcs19-p5-01-13
https://doi.org/10.1158/1538-7445.sabcs19-p5-01-13
Autor:
Maria S. Alexis, Gene W. Yeo, Peter Freese, Myles Hochman, Brenton R. Graveley, Eric L. Van Nostrand, Daniel Dominguez, Tsultrim Palden, Gabriel A. Pratt, Cassandra Bazile, Christopher B. Burge, Amanda Su, Nicole J. Lambert
Publikováno v:
Elsevier
RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased assay that determines the sequence, structure, and context preferences of these pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5499a77f4c9865a1a2fc6c89b8025c6f
Autor:
Louis Philip Benoit Bouvrette, Gabriel A. Pratt, Neal A.L. Cody, Julie Bergalet, Bing Zhou, Brenton R. Graveley, Chelsea Gelboin-Burkhart, Christopher B. Burge, Balaji Sundararaman, Xiaofeng Wang, Ruth Wang, Xiang-Dong Fu, Brian A. Yee, Shashank Sathe, Lijun Zhan, Eric L. Van Nostrand, Michael O. Duff, Eric Lécuyer, Gene W. Yeo, Ashley L. Louie, Amanda Su, Rui Xiao, Sara H. Olson, Cassandra Bazile, Thai B. Nguyen, Xintao Wei, Stefan Aigner, Ines Rabano, Rebecca Stanton, Hairi Li, Keri E. Garcia, Tsultrim Palden, Peter Freese, Abigail Hochman, Daniel Dominguez, Steven M. Blue, Jia-Yu Chen, Nicole J. Lambert
Genomes encompass all the information necessary to specify the development and function of an organism. In addition to genes, genomes also contain a myriad of functional elements that control various steps in gene expression. A major class of these e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c2f9ab0038c2147dad60349f86190c
Autor:
John C Spinosa, Becky Wong, David C. Chan, Ken Nesmith, Peter M. George, Young Kwang Chae, Rohith Srivas, Abhik Shah, Ayse Tezcan, Timothy R. Wilson, Michael S. Oh, Haluk Tezcan, Andrew M. Davis, Robert W. Lentz, Ram Yalamanchili, Wade T. Iams, Alex Robertson, Nicole J. Lambert, Neil Peterman
Publikováno v:
Cancer Research. 79:2279-2279
Background: Response to cancer treatment is usually determined by clinical exam and imaging assessment. Here, we analyzed changes in tumor-derived whole-genome cell-free DNA (cfDNA) at baseline and after treatment initiation to determine response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37cc37567e420b821cf3a9d1f202d8e
https://doi.org/10.1158/1538-7445.am2019-2279
https://doi.org/10.1158/1538-7445.am2019-2279