Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nicole I. Orazio"'
Autor:
Matthew D. Weitzman, Nicole I. Orazio, Tony Hunter, Brandon J. Lamarche, Zhongsheng You, Brittany Goben, Jill Meisenhelder
Publikováno v:
DNA Repair (Amst)
The DNA double strand breaks (DSBs) created during meiotic recombination and during some types of chemotherapy contain protein covalently attached to their 5' termini. Removal of the end-blocking protein is a prerequisite to DSB processing by non-hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117bae324f77eb1b9c1004ddfce7dc51
https://europepmc.org/articles/PMC8057058/
https://europepmc.org/articles/PMC8057058/
Publikováno v:
Journal of Virology. 85:1887-1892
The adenovirus (Ad) E1b55K and E4orf6 gene products assemble an E3 ubiquitin ligase complex that promotes degradation of cellular proteins. Among the known substrates are p53 and the Mre11-Rad50-Nbs1 (MRN) complex. Since members of the RecQ helicase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39f0c2391a18e2b05ccf2a843d48189
https://doi.org/10.1128/jvi.02134-10
https://doi.org/10.1128/jvi.02134-10
Autor:
Christian T. Carson, Darwin V. Lee, Jiri Lukas, Matthew D. Weitzman, Nicole I. Orazio, Seema S. Lakdawala, Caroline E. Lilley, Jiri Bartek, Junghae Suh, Felipe D. Araujo, Simon Bekker-Jensen
Publikováno v:
The EMBO Journal. 28:652-662
The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e72dc1a5b0d96adbf044a7e683d355
https://doi.org/10.1038/emboj.2009.15
https://doi.org/10.1038/emboj.2009.15
Publikováno v:
Journal of Virology. 81:11730-11736
We have previously shown that treatment of human cytomegalovirus-infected cells with the cyclin-dependent kinase (cdk) inhibitor roscovitine has significant effects on several stages of the virus life cycle depending on the time of addition (V. Sanch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274363fdaabe23fa938afb0de5a4d16d
https://doi.org/10.1128/jvi.02760-06
https://doi.org/10.1128/jvi.02760-06
Autor:
Nicole I. Orazio, Jenny P.-Y. Ting, Thomas J. Kelly, Jae U. Jung, Mary A. Rodgers, Qiming Liang, Hiroaki Fujita, Mude Shi, Rina Amatya, Kazuhiro Iwai, James W. Bowman
Publikováno v:
The Journal of Experimental Medicine
Independent of its known role in NF-κB transcription, the HOIL-1L containing LUBAC is required for assembly and activation of the NLRP3 inflammasome via linear ubiquitination of ASC.
Linear ubiquitination is a newly discovered posttranslational
Linear ubiquitination is a newly discovered posttranslational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e6f7972bc202777074049c80152206
https://pubmed.ncbi.nlm.nih.gov/25086647
https://pubmed.ncbi.nlm.nih.gov/25086647
Autor:
A. F. Tyler, Matthew D. Weitzman, Nicole I. Orazio, H. P. Adams, H. B. Fleisig, Han Liang, Lalitha Nagarajan
Publikováno v:
Oncogene. 26(33)
Sequence-specific single-stranded DNA-binding protein 2 (SSBP2) is a candidate tumor suppressor for human acute myelogenous leukemia (AML). Inducible expression of SSBP2 causes growth arrest and partial differentiation in AML cells. Here, we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb9ed607ef7bf9d9ed85aa06771279
https://pubmed.ncbi.nlm.nih.gov/17311003
https://pubmed.ncbi.nlm.nih.gov/17311003
Publikováno v:
FEBS Letters. (17):3682-3695
Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein–DNA compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b8fa81a1c9ece1f9a6d3bf8a02a9fa