Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nicole Hermance"'
Autor:
Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range
Externí odkaz:
https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a06
Autor:
Joanne A. O’Donnell, Michelle A. Kelliher, Jesse Lehman, Justine E. Roderick, Katherine A. Fitzgerald, Nicole Hermance, Ann Marshak-Rothstein, Matija Zelic, Stephen Lyle, Manolis Pasparakis, Dalia Martinez-Marin, Ciara G. Doran
Publikováno v:
The Journal of Immunology. 200:737-748
Necroptosis is a form of cell death associated with inflammation; however, the biological consequences of chronic necroptosis are unknown. Necroptosis is mediated by RIPK1, RIPK3, and MLKL kinases but in hematopoietic cells RIPK1 has anti-inflammator
Autor:
Justine E. Roderick, Michelle A. Kelliher, Ciara G. Doran, Matija Zelic, Joanne A. O’Donnell, Dalia Martinez-Marin, Manolis Pasparakis, Katherine A. Fitzgerald, Stephen Lyle, Jesse Lehman, Nicole Hermance, Ann Marshak-Rothstein
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(8)
Necroptosis is a form of cell death associated with inflammation, however the biological consequences of chronic necroptosis are unknown. Necroptosis is mediated by RIPK1, RIPK3 and MLKL kinases but in hematopoietic cells RIPK1 has anti-inflammatory
Autor:
Anuradha Illendula, John H. Bushweller, Jessica Tesell, John Anto Pulikkan, Justine E. Roderick, Jun Yu, Nicole Hermance, Lucio H. Castilla, Lihua Julie Zhu, Michelle A. Kelliher, AHyun Choi
Publikováno v:
Blood. 130(15)
The gene encoding the RUNX1 transcription factor is mutated in a subset of T-cell acute lymphoblastic leukemia (T-ALL) patients, and RUNX1 mutations are associated with a poor prognosis. These mutations cluster in the DNA-binding Runt domain and are
Autor:
Pallavi Gandhi, Sarah Morrissey, Mary Munson, Fang Xia, Sara J.S. Simonson, Angela M. Mabb, Yibin Yang, Michelle A. Kelliher, Shigeki Miyamoto, Nicole Hermance
Publikováno v:
Molecular and Cellular Biology. 31:2774-2786
In multiple tumor types, activation of the transcription factor NF-κB increases the resistance of tumor cells to anticancer therapies and contributes to tumor progression. Genotoxic stress induced by chemotherapy or radiation therapy triggers the AT
Autor:
Veena Krishnamoorthy, Kathleen Cullion, Nicole Hermance, George N. Nikov, Kyle M. Draheim, Christopher Ware, Michelle A. Kelliher, Jennifer Tammam, Pradip K. Majumder, Vishva Mitra Sharma
Publikováno v:
Blood. 113:6172-6181
Mutations in NOTCH1 are frequently detected in patients with T-cell acute lymphoblastic leukemia (T-ALL) and in mouse T-ALL models. Treatment of mouse or human T-ALL cell lines in vitro with γ-secretase inhibitors (GSIs) results in growth arrest and
Autor:
Veena Krishnamoorthy, Jennifer A. Calvo, Leslie A. Cunningham, Manoj Bhasin, Anthony J. Capobianco, Vishva Mitra Sharma, Levi J. Beverly, Nicole Hermance, Michelle A. Kelliher, Kyle M. Draheim
Publikováno v:
Molecular and Cellular Biology. 26:8022-8031
Recent work with mouse models and human leukemic samples has shown that gain-of-function mutation(s) in Notch1 is a common genetic event in T-cell acute lymphoblastic leukemia (T-ALL). The Notch1 receptor signals through a gamma-secretase-dependent p
Autor:
Manolis Pasparakis, Matija Zelic, Justine E. Roderick, Apostolos Polykratis, Matthew J. Simmons, Nicole Hermance, Michelle A. Kelliher
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(40)
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. RIPK1 deficiency results in postnatal lethality, but precisely why Ripk1(-/
Autor:
André Bleich, Marius Dannappel, Nicole Hermance, Petra Kirsch, Teresa Corona, Juan Lin, Matija Zelic, Marijana Basic, Katerina Vlantis, Manolis Pasparakis, Christina Eftychi, Snehlata Kumari, Michelle A. Kelliher, Laurens Wachsmuth, Chun Kim, Apostolos Polykratis
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation1–8. RIPK1 is implicated in inflammatory and cell death signalling9–13 and its kinase activity is beli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c682e77063cea943de76ebc327813c5a
https://europepmc.org/articles/PMC4206266/
https://europepmc.org/articles/PMC4206266/
Autor:
Manolis Pasparakis, Nicole Hermance, Francis Ka-Ming Chan, Michelle A. Kelliher, Trieu-My Van, Chun Kim, Matija Zelic, Justine E. Roderick, Apostolos Polykratis, Thomas H. Lee
Publikováno v:
The Journal of Immunology
The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. A RIPK1 deficiency results in perinatal lethality, impaired NFκB and MAPK signaling, and sensitivity to TNF-induced