Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole Hartig"'
Autor:
Greg G. Jones, Isabel Boned del Río, Sibel Sari, Aysen Sekerim, Lucy C. Young, Nicole Hartig, Itziar Areso Zubiaur, Mona A. El-Bahrawy, Rob E. Hynds, Winnie Lei, Miriam Molina-Arcas, Julian Downward, Pablo Rodriguez-Viciana
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Targeted inhibition of the ERK-MAPK pathway is challenged by the development of resistance and toxicity. Here, the authors show that SHOC2 genetic inhibition impairs lung tumour development and improves MEK inhibitor efficacy in RAS- and EGFR-mutant
Externí odkaz:
https://doaj.org/article/63c728d50eef448aa2fdb9117a059704
Autor:
Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://doaj.org/article/060b7e02b03d49888281c2e401c2133d
Autor:
Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu
Publikováno v:
Nature structuralmolecular biology. 29(10)
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af969c6552b8ea187cbaa14a6a178876
https://pubmed.ncbi.nlm.nih.gov/36175670
https://pubmed.ncbi.nlm.nih.gov/36175670
Autor:
Greg G. Jones, Sibel Sari, Pablo Rodriguez-Viciana, Nicole Hartig, Amandeep Bhamra, Ewa Rejnowicz, Isabel Boned del Río, Benjamin Ringham-Terry, Winnie Lei, Lucy C. Young, Silvia Surinova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Significance The ERK signaling pathway is hyperactivated in a majority of cancers. However, because it mediates myriad physiological responses, the clinical efficacy of current ERK pathway inhibitors has been severely limited by toxicity. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fc24a24bc8e5b6eeae72bb00d076d9
http://europepmc.org/articles/PMC6613145
http://europepmc.org/articles/PMC6613145
Autor:
Alma L. Burlingame, Warren Emmett, Andreas Blees, Fabian Brunk, Silvia Surinova, Anne E. Roehrig, Marta Munoz-Alegre, Alexander Hergovich, Kristina Klupsch, Maha Tijani, Anett Pfeiffer, Juan A. Oses-Prieto, Stephen Henderson, Pablo Rodriguez-Viciana, Nicole Hartig, Selim Chaib, Barbara H. Jennings, Lucy C. Young
Publikováno v:
PloS one, vol 16, iss 8
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e0538a32a3dbbdd2c44b48de833dd
https://escholarship.org/uc/item/57d9s6th
https://escholarship.org/uc/item/57d9s6th
Autor:
Stephen Henderson, Alma L. Burlingame, Marta Munoz-Alegre, Alexander Hergovich, A. E. Roehrigh, Juan A. Oses-Prieto, Pablo Rodriguez-Viciana, A. Blees, K. Klupsch, Barbara H. Jennings, Nicole Hartig, Warren Emmett, Silvia Surinova, F. Brunk, A. Pfeiffer, S. Chaib, Maha Tijani, Lucy C. Young
SUMMARYThe PAF complex (PAFC) coordinates transcription elongation and mRNA processing events and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions at the cell cortex and nucleus and is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa1052b053cce99932ff3d641a4d05
https://doi.org/10.1101/717769
https://doi.org/10.1101/717769
Autor:
Sibel Sari, Nicole Hartig, Aysen Sekerim, Julian Downward, Itziar Areso Zubiaur, Miriam Molina-Arcas, Winnie Lei, Greg G. Jones, Isabel Boned del Río, Lucy C. Young, Mona El-Bahrawy, Pablo Rodriguez-Viciana, Robert E. Hynds
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, vol 10, iss 1
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15759a18dcea667dd571fac74d527842
http://europepmc.org/articles/PMC6557854
http://europepmc.org/articles/PMC6557854
Autor:
Sibel Sari, Isabel Boned del Río, Julian Downward, Nicole Hartig, Mona El-Bahrawy, Aysen Sekerim, Pablo Rodriguez-Viciana, Miriam Molina-Arcas, Greg G. Jones, Lucy C. Young
Publikováno v:
Molecular Cancer Research. 18:B26-B26
Mutual exclusivity of RAS and BRAF mutations in multiple cancer types illustrates the key role of the RAF-MEK-ERK signaling pathway in mediating RAS oncogenesis. Although MEK inhibitors in particular are potent and specific, their on-target toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad89c7b512c25deb6a11471111ad1f7
https://doi.org/10.1158/1557-3125.ras18-b26
https://doi.org/10.1158/1557-3125.ras18-b26
Autor:
Frank McCormick, Greg G. Jones, Joshua R. Wainwright, Lucy C. Young, Nicole Hartig, Benjamin Ringham-Terry, Sibel Sari, Isabel Boned del Río, Pablo Rodriguez-Viciana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 45
Dephosphorylation of the inhibitory "S259" site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS oncoproteins, interacts with SHOC2 and protein phosphatase 1 (PP1) to form a hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043fd74764d8eeaa7289fdbb429b878f
https://escholarship.org/uc/item/9ct3g7st
https://escholarship.org/uc/item/9ct3g7st
Autor:
Lucy C. Young, Vineetha Vijayakumar, Rupinder Ghatrora, Christina Gewinner, Juan A. Oses-Prieto, Stephen Henderson, Matteo Vietri Rudan, Mark F. Lythgoe, Marta Munoz-Alegre, Sevi Durdu, Sabine Bender, Pablo Rodriguez-Viciana, Nicole Hartig, Amit P. Jathoul, Alma L. Burlingame
Publikováno v:
Molecular Cell. 52(5):679-692
SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human cancers. SHOC2 functions as a PP1-regulatory protein and as an effector of MRAS. Here we show that SHOC2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2cc455ebc7bbbe2fa898f66c50f46b