Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nicole Hamagami"'
Autor:
Diana C. Beard, Xiyun Zhang, Dennis Y. Wu, Jenna R. Martin, Alyssa Erickson, Jane Valeriane Boua, Nicole Hamagami, Raylynn G. Swift, Katherine B. McCullough, Xia Ge, Austin Bell-Hensley, Hongjun Zheng, Cory W. Palmer, Nicole A. Fuhler, Austin B. Lawrence, Cheryl A. Hill, Thomas Papouin, Kevin K. Noguchi, Audrey McAlinden, Joel R. Garbow, Joseph D. Dougherty, Susan E. Maloney, Harrison W. Gabel
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113411- (2023)
Summary: Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood. Here, we investigate
Externí odkaz:
https://doaj.org/article/48fc308841a24ec68b568d4410c3c83e
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier, Tamara L. Davis
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retain differences in alle
Externí odkaz:
https://doaj.org/article/35c8c5f4891c4780a26b0e6188c3eb11
Autor:
Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin oc
Externí odkaz:
https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
Autor:
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 400-415.e5 (2019)
Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis. The acetyl-lysine binding protein BRD4 has been previousl
Externí odkaz:
https://doaj.org/article/8b145c50765d4778bd5ce4df11b251aa
Publikováno v:
bioRxiv
SummaryDuring postnatal development the DNA methyltransferase DNMT3A deposits high levels of non-CG cytosine methylation in neurons. This unique methylation is critical for transcriptional regulation in the mature mammalian brain, and loss of this ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e9adeebb93fef0b651d385262f4597
https://europepmc.org/articles/PMC9949142/
https://europepmc.org/articles/PMC9949142/
Autor:
Nicole Hamagami, Michael T. Werner, Jennifer A. Yano, Sarah C. Hsu, Hongxin Wang, Aaron J. Stonestrom, Gerd A. Blobel, Yichen Zhong, Vivek Behera, Joel P. Mackay
Publikováno v:
Journal of Biological Chemistry. 295:1898-1914
The widely expressed bromodomain and extraterminal motif (BET) proteins bromodomain-containing protein 2 (BRD2), BRD3, and BRD4 are multifunctional transcriptional regulators that bind acetylated chromatin via their conserved tandem bromodomains. Sma
Autor:
Michael T. Werner, Hongxin Wang, Nicole Hamagami, Sarah C. Hsu, Jennifer A. Yano, Aaron J. Stonestrom, Vivek Behera, Yichen Zhong, Joel P. Mackay, Gerd A. Blobel
Publikováno v:
J Biol Chem
The widely expressed bromodomain and extraterminal motif (BET) proteins bromodomain-containing protein 2 (BRD2), BRD3, and BRD4 are multifunctional transcriptional regulators that bind acetylated chromatin via their conserved tandem bromodomains. Sma
Autor:
Nicole Hamagami, Carol Hager
Publikováno v:
Rev Policy Res
Our article explores the contribution of local initiatives to the creation of path dependencies for energy transition in Germany and Japan in the face of resistance from entrenched incumbents at the national level. We use a process-tracing methodolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d605e06047869c2575950ff5b45a6aca
https://europepmc.org/articles/PMC8009489/
https://europepmc.org/articles/PMC8009489/
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Autor:
Ross C. Hardison, Saurabh K. Bhardwaj, Carolyne J. Face, Stella T. Chou, Christopher R. Edwards, Stephen A. Liebhaber, Gerd A. Blobel, Xianjiang Lan, Ben A. Garcia, Junwei Shi, Laavanya Sankaranarayanan, David Posocco, Simone Sidoli, Belinda Giardine, Nicole Hamagami, Osheiza Abdulmalik, Jeremy D. Grevet, Cheryl A. Keller, Xinjun Ji
Publikováno v:
Science. 361:285-290
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin