Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nicole Hallahan"'
Autor:
Dillon Jevon, Kylie Deng, Nicole Hallahan, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
Publikováno v:
eLife, Vol 11 (2022)
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Externí odkaz:
https://doaj.org/article/20dc23e379ba40cab6b3df7b4494ac7e
Autor:
Heja Aga, Nicole Hallahan, Pascal Gottmann, Markus Jaehnert, Sophie Osburg, Gunnar Schulze, Anne Kamitz, Danny Arends, Gudrun Brockmann, Tanja Schallschmidt, Sandra Lebek, Alexandra Chadt, Hadi Al-Hasani, Hans-Georg Joost, Annette Schürmann, Heike Vogel
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility
Externí odkaz:
https://doaj.org/article/c1879ec999634ac1a25ae539c9841c9e
Autor:
Pascal Gottmann, Meriem Ouni, Sophie Saussenthaler, Julian Roos, Laura Stirm, Markus Jähnert, Anne Kamitz, Nicole Hallahan, Wenke Jonas, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger, Matthias Blüher, Pamela Fischer-Posovszky, Heike Vogel, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 145-159 (2018)
Objective: Obesity and type 2 diabetes (T2D) arise from the interplay between genetic, epigenetic, and environmental factors. The aim of this study was to combine bioinformatics and functional studies to identify miRNAs that contribute to obesity and
Externí odkaz:
https://doaj.org/article/b43f895593b3447b9e47be298c257584
Autor:
Kim Cheng, Viviane Delghingaro-Augusto, Christopher J Nolan, Nigel Turner, Nicole Hallahan, Sofianos Andrikopoulos, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40868 (2012)
Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP) MIN6 cell
Externí odkaz:
https://doaj.org/article/eb70c21f5557456a87223dfd6015e7e6
Autor:
Nicole Hallahan, Kylie Deng, Dillon Jevon, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
Publikováno v:
eLife. 11
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Publikováno v:
Journal of Biological Chemistry. 299:104343
Autor:
Nicole Hallahan, Kylie Deng, Dillon Jevon, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
A developing understanding suggests that spatial compartmentalisation of components the glucose stimulus-secretion pathway in pancreatic β cells are critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8708a5fa21c6d1b797666704845bcfe6
https://doi.org/10.1101/2021.12.21.473760
https://doi.org/10.1101/2021.12.21.473760
Autor:
Dillon, Jevon, Kylie, Deng, Nicole, Hallahan, Krish, Kumar, Jason, Tong, Wan Jun, Gan, Clara, Tran, Marcela, Bilek, Peter, Thorn
Publikováno v:
eLife. 11
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Autor:
Elena Kosobrodova, Nicole Hallahan, Clara T. H. Tran, Marcela M.M. Bilek, Jason Tong, Peter Thorn
Publikováno v:
Coatings
Volume 11
Issue 9
Coatings, Vol 11, Iss 1085, p 1085 (2021)
Volume 11
Issue 9
Coatings, Vol 11, Iss 1085, p 1085 (2021)
Implant devices containing insulin-secreting β-cells hold great promise for the treatment of diabetes. Using in vitro cell culture, long-term function and viability are enhanced when β-cells are cultured with extracellular matrix (ECM) proteins. He