High affinity Grb2-SH3 domain ligand incorporating Cβ-substituted prolines in a Sos-derived decapeptide

Autor: Solange Lavielle, Charlotte Joss, Olivier Lequin, Philippe Karoyan, Emeric Miclet, Yves Jacquot, Isabelle Broutin, Michel Desmadril, Magali Nicaise, Arnaud Ducruix, Nicole Goasdoué

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 ((3)), pp.1439-47. ⟨10.1016/j.bmc.2006.11.002⟩
Bioorganic and Medicinal Chemistry, 2007, 15 ((3)), pp.1439-47. ⟨10.1016/j.bmc.2006.11.002⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2007, 15 ((3)), pp.1439-47. 〈10.1016/j.bmc.2006.11.002〉

International audience; Peptide ligands that disrupt MAPK pathways are of great interest for a better understanding of these signalling cascades and represent therefore an attractive target to control cell degenerative processes. In that context, sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc240cd35b27184815a3a283525fb21
https://doi.org/10.1016/j.bmc.2006.11.002

Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution

Autor: Isabel D. Alves, Sandrine Sagan, Nicole Goasdoué, Solange Lavielle, Gérard Chassaing, Soline Aubry, Isabelle Correia, Cécile Galanth

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2010, 1780 ((7-8)), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1780 (7-8), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2008, 1780 (7-8), pp.948-959. ⟨10.1016/j.bbagen.2008.04.004⟩
BBA-Biochimica et Biophysica Acta, 2010, 1780 ((7-8)), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2008, 1780 (7-8), pp.948-959. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1780 (7-8), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩

International audience; Independently from the cell penetrating peptide uptake mechanism (endocytic or not), the interaction of the peptide with the lipid bilayer remains a common issue that needs further investigation. The cell penetrating or antimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0841a02313e558fca12f91b54a996e
https://hal.archives-ouvertes.fr/hal-00407766

Biotin synthase mechanism : Mutagenesis of the YNHNLD Conserved Motif

Autor: Dominique Florentin, Evelyne Raux, Nicole Goasdoué, Bernadette Tse Sum Bui, Francine Libot, Andrée Marquet, Martin J. Warren, Manuela Lotierzo

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2006, 45, pp.12274-12281
Biochemistry, 2006, 45, pp.12274-12281

Biotin synthase, a member of the "radical SAM" family, catalyzes the final step of the biotin biosynthetic pathway, namely, the insertion of a sulfur atom into dethiobiotin (DTB). The active form of the enzyme contains two iron-sulfur clusters, a [4F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a0b81f8e7512a066957b3768129ad7
https://hal.archives-ouvertes.fr/hal-00116208

Characterization of cyclonerodiol isolated from corn infested byfusarium moniliforme sheld.: One- and two-dimensional1H and13C NMR study

Autor: F. Kohler, Nicole Platzer, Nicole Goasdoué, F. Pellegrin, D. Laurent

Publikováno v: Magnetic Resonance in Chemistry. 28:662-664

A metabolite extracted from maize culture was identified as cyclonerodiol. Its 1H and 13C NMR spectra have been fully analysed, and some literature assignments have been reversed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a080438905f3893ab83ea0019f04fba
https://doi.org/10.1002/mrc.1260280721

Long-range1H coupling interactions: Identification of different pathways by 2D NMR δ—δ correlated spectroscopy. Applications in structural analysis

Autor: Nicole Goasdoué, D. Davoust, Nicole Platzer

Publikováno v: Magnetic Resonance in Chemistry. 25:311-319

The simplest methods of 2D δ-δ correlated spectroscopy (COSY and COSY LR) allow the easy observation of long-range coupling interactions. It is shown how these methods can lead to the discrimination between different pathways across single bonds: 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd90396be275fcea3b45ece92cb815e
https://doi.org/10.1002/mrc.1260250408