Výsledky vyhledávání - "Nicole Georgi"

Akademický článek

Nanostructured 3D constructs based on chitosan and chondroitin sulphate multilayers for cartilage tissue engineering.

Autor: Joana M Silva, Nicole Georgi, Rui Costa, Praveen Sher, Rui L Reis, Clemens A Van Blitterswijk, Marcel Karperien, João F Mano

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55451 (2013)

Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositin

Externí odkaz: https://doaj.org/article/c61c6e6be56d459b936e7072c81c6b69

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O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models

Autor: Ellie B. M. Landman, Clemens van Blitterswijk, Marcel Karperien, Travis J. Klein, Nicole Georgi

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 11:724-732

Hypoxia has been shown to be important for maintaining cartilage homeostasis as well as for inducing chondrogenic differentiation. Ensuring low oxygen levels during in vitro culture is difficult, therefore we assessed the chondro-inductive capabiliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05a03a4376ded17158e10476efac32b7
https://doi.org/10.1002/term.1969

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Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Autor: Janine N. Post, Marcel Karperien, Liliana Moreira Teixeira, Nicole Georgi, Clemens van Blitterswijk, Jeroen Leijten

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13954-13959. National Academy of Sciences

Actively steering the chondrogenic differentiation of mesenchymal stromal cells (MSCs) into either permanent cartilage or hypertrophic cartilage destined to be replaced by bone has not yet been possible. During limb development, the developing long b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a3084e4c9c89123e639b4907122675
https://doi.org/10.1073/pnas.1410977111

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Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures

Autor: Clemens van Blitterswijk, Ling Wu, Nicole Georgi, Marcel Karperien, Jeroen Leijten

Publikováno v: Tissue engineering. Part B: Reviews, 19(1), 31-40. Mary Ann Liebert

The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years, cartilage tissue engineering has shown great promise. As with all tissue engineer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389575218f0175d141a73f653ef5a7a8
https://doi.org/10.1089/ten.teb.2012.0273

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MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

Autor: Jan de Boer, Clemens van Blitterswijk, C.C. Raiss, Karolina Janaeczek Portalska, Marcel Karperien, Janine N. Post, Andre J. van Wijnen, Nicole Georgi, Nathalie Groen, Hanna Taipaleenmäki

Publikováno v: Stem Cells and Development, 24(16), 1946-1955. Mary Ann Liebert Inc.
Stem cells and development, 24(16), 1946-1955. Mary Ann Liebert

The ability of human mesenchymal stromal/stem cells (hMSCs) to differentiate into various mesenchymal cell lineages makes them a promising cell source for the use in tissue repair strategies. Since the differentiation potential of hMSCs differs betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3accfbe05ccc0af0e269ba8a8bbcea41
https://europepmc.org/articles/PMC4533023/

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Differentiation of mesenchymal stem cells under hypoxia and normoxia: lipid profiles revealed by time-of-flight secondary ion mass spectrometry and multivariate analysis

Autor: Nicole Georgi, Andras Kiss, Clemens van Blitterswijk, Berta Cillero-Pastor, Marcel Karperien, Janine N. Post, Gert B. Eijkel, P.C. Periyasamy, Ron M. A. Heeren

Publikováno v: Analytical Chemistry, 87(7), 3981-3988. American Chemical Society
Analytical chemistry, 87(7), 3981-3988. American Chemical Society

Mesenchymal stem cells (MSC) have the ability to self-renew and differentiate into multiple cell types valuable for clinical treatment of rheumatic pathologies. To study the chondrogenic potential of MSC and identify the conditions that recreate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d68eb04dfd54be656304f6a26934a
https://pubmed.ncbi.nlm.nih.gov/25742117

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Lipids as mediators of chondrogenesis

Autor: Ron M. A. Heeren, P.C. Periyasamy, Nicole Georgi, Gert B. Eijkel, B. Cillero Pastor, Marcel Karperien, Andras Kiss, Janine N. Post, C.A. van Blitterswijk

Publikováno v: STARTPAGE=S46;ENDPAGE=S48;TITLE=2014 OARSI World Congress on Osteoarthritis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459e0d705cf13053f4be89701eeb9405
https://research.utwente.nl/en/publications/lipids-as-mediators-of-chondrogenesis(4355ad0e-f714-4a4d-8d1f-65a229d1139b).html

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Mesenchymal Stromal/Stem Cell–or Chondrocyte-Seeded Microcarriers as Building Blocks for Cartilage Tissue Engineering

Autor: Marcel Karperien, Clemens van Blitterswijk, Nicole Georgi

Publikováno v: Tissue engineering. Part A, 20(17-18), 2513-2523. Mary Ann Liebert
Tissue Engineering, 20(17-18), 2513-2523. Mary Ann Liebert Inc.

In this study we have tested the use of mesenchymal stromal/stem cell (MSC)- or chondrocyte (hch)-laden microcarriers as building blocks for engineered cartilage tissue. MSCs and hchs expanded on microcarriers were used in chondrogenic coculture and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441a131e507ef8845964bf2df98f9278
https://research.utwente.nl/en/publications/890b6d6f-ab43-4c7b-a8a4-3d663124397c

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O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models

Autor: Nicole, Georgi, Ellie B M, Landman, Travis J, Klein, Clemens A, van Blitterswijk, Marcel, Karperien

Publikováno v: Journal of tissue engineering and regenerative medicine. 11(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98a15b80277560143e171dcc85dfc285
https://pubmed.ncbi.nlm.nih.gov/25414128

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