Výsledky vyhledávání - "Nicole G. Manning"

The Transcription Factor ZEB1 Is Aberrantly Expressed in Aggressive Uterine Cancers

Autor: Yujiro Higashi, Russell Broaddus, Nicole G. Manning, Douglas S. Darling, Meenakshi Singh, Nicole S. Spoelstra, Kenneth R. Shroyer, Kathryn B. Horwitz, Jennifer K. Richer

Publikováno v: Cancer Research. 66:3893-3902

The transcription factor ZEB1 (δEF1 in mice) has been implicated in cellular processes during development and tumor progression including epithelial to mesenchymal transition. δEF1 null mice die at birth, but heterozygotes expressing a LacZ reporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8e8cc479419a0c314fdf13e8a187df
https://doi.org/10.1158/0008-5472.can-05-2881

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Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells

Autor: James M. Haughian, S. Kelly Ambler, Nicole G. Manning, Kathryn B. Horwitz, Paul Jedlicka, Päivi Heikkilä, Kristiina Joensuu, Ndiya Ogba, Brian S Bliesner, Mauricio P. Pinto

Publikováno v: Breast Cancer Research : BCR

Introduction Luminal, estrogen receptor-positive (ER+) breast cancers can metastasize but lie dormant for years before recurrences prove lethal. Understanding the roles of estrogen (E) or progestin (P) in development of luminal metastases or in arous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b576fc20ff170fc84cbbd1a8b1483ef5
http://hdl.handle.net/10138/211837

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Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer

Autor: Kathryn B. Horwitz, Gareth I. Owen, Carol A. Lange, Roger Powell, Nicole G. Manning, Jennifer K. Richer

Publikováno v: Journal of Biological Chemistry. 273:31317-31326

STATS (signal transducers and activators of transcription) are latent transcription factors activated in the cytoplasm by diverse cell surface signaling molecules. Like progesterone receptors (PR), Stat5a and 5b are required for normal mammary gland

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebbb9ea78c3055179a6b62f51b49577f
https://doi.org/10.1074/jbc.273.47.31317

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Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis

Autor: Miriam D. Post, Monique A. Spillman, Britta M. Jacobsen, Wendy W. Dye, Carol A. Sartorius, Joshua Chuck Harrell, Kathryn B. Horwitz, Nicole G. Manning

Publikováno v: Cancer research. 70(21)

Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)–positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed preexisting disease is unknown. To determine E2 effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff15346f4e7fc871ad3c4b05d7d48ed
https://pubmed.ncbi.nlm.nih.gov/20959477

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Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells

Autor: Nicole G. Manning, Cheryl A. Pickett, Arthur Gutierrez-Hartmann, Yoshiko Akita

Publikováno v: Molecular endocrinology (Baltimore, Md.). 16(12)

Epidermal growth factor (EGF) and TRH both produce enhanced prolactin (PRL) gene transcription and PRL secretion in GH4 rat pituitary tumor cell lines. These agents also activate protein kinase C (PKC) in these cells. Previous studies have implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517caf2a488a6ee97ed53bbcfdb039fd
https://pubmed.ncbi.nlm.nih.gov/12456804

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Role of Progesterone Receptor Isoforms in Regulation of Cell Adhesion and Apoptosis

Autor: Jennifer K. Richer, Nicole G. Manning

Progesterone receptors (PR) and estrogen receptors (ER) are important prognostic indicators in breast cancer. We believe that PR, in addition to being an indicator of functional ER, can play a role in the progression of breast cancer in its own right

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfae0040bc807936899d1e208a9d571b
https://doi.org/10.21236/ada407539

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Abstract A63: Tamoxifen effectively suppresses both initiation of intraperitoneal tumors and established ovarian cancer growth in a fluorescent xenograft model

Autor: Douglas A. Hicks, Monique A. Spillman, Nicole G. Manning

Publikováno v: Clinical Cancer Research. 19:A63-A63

Background: Sixty percent of serous ovarian carcinomas express the estrogen receptor (ER). The antiestrogen (AE) Tamoxifen and aromatase inhibitors (AI) are common therapies for chemoprevention and treatment of ER+ breast cancers, but have not been r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1636a421e5a33969f0a4f4a97015fd8
https://doi.org/10.1158/1078-0432.ovca13-a63

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Abstract 1388: Luminal breast cancer metastasis is hormone-dependent and progesterone activates dormant disease

Autor: Nicole G. Manning, James M. Haughian, Kathryn B. Horwitz, Brian S Bliesner, Ndiya Ogba, Kelly Ambler, Mauricio P. Pinto

Publikováno v: Cancer Research. 73:1388-1388

Luminal, estrogen (ER) and/or progesterone (PR) receptor-positive breast cancers are the least aggressive forms of the disease. However, luminal cancers are the most common (70-80%) breast cancer subtype and therefore overall responsible for the grea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e64558780b5f9e91f38bb286599a1a5
https://doi.org/10.1158/1538-7445.am2013-1388

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