Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicole Farwick"'
Autor:
Sareetha Kailayangiri, Bianca Altvater, Nicole Farwick, Jutta Meltzer, Wolfgang Hartmann, Claudia Rossig
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103199- (2024)
Summary: The detection of disialoganglioside GD2 on tumor biopsies, especially in paraffin-embedded tissues, has been challenging due to the glycolipid structure of GD2 and its membrane anchorage. Here, we present an immunofluorescence protocol for t
Externí odkaz:
https://doaj.org/article/6e27c866a2b14a24a2b2706fc20cf9d4
Autor:
Silke Jamitzky, Bianca Altvater, Carolin Krekeler, Laura Hoen, Caroline Brandes, Julia Ebbinghaus, Lisa Richter, Lisa Kosel, Laurin Ochs, Nicole Farwick, Katja Urban, Lena Kluge, Lara Bücker, Dennis Görlich, Ian C. D. Johnston, Rita Pfeifer, Wolfgang Hartmann, Claudia Rossig, Sareetha Kailayangiri
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Carbohydrate markers of immature cells during prenatal human development can be aberrantly expressed in cancers and deserve evaluation as immune targets. A candidate target in Ewing sarcoma is the globo-series ganglioside stage-specific embr
Externí odkaz:
https://doaj.org/article/c7a03da52b4a4a629ef2068b60b10500
Autor:
Claudia Rossig, Bianca Altvater, Lea Greune, Simone König, Jutta Meltzer, Wolfgang Hartmann, Dennis Görlich, Katja Urban, Sareetha Kailayangiri, Lina F. Pérez Lanuza, Maike Flügge, Nicole Farwick
Publikováno v:
Cancers
Cancers; Volume 13; Issue 12; Pages: 2857
Cancers, Vol 13, Iss 2857, p 2857 (2021)
Cancers; Volume 13; Issue 12; Pages: 2857
Cancers, Vol 13, Iss 2857, p 2857 (2021)
Simple Summary Solid cancers can effectively counteract immune attack by inhibitory checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could be a useful tool for enhancing the efficacy of antitumor T cell therapies. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aa789e680ef785a51f30f29ceb5c50
http://europepmc.org/articles/PMC8227123
http://europepmc.org/articles/PMC8227123
Autor:
Julia Meyer, Hanna Huebner, Ramona Erber, Carol Geppert, Arndt Hartmann, Peter A. Fasching, Matthias Ruebner, Laura Landgraf, Simon Völkl, Paul Gass, Andreas Mackensen, Lothar Häberle, Matthias W. Beckmann, Sareetha Kailayangiri, Rüdiger Schulz-Wendtland, Nicole Farwick, Claudia Rossig
Publikováno v:
Cancers
Cancers, Vol 13, Iss 5577, p 5577 (2021)
Volume 13
Issue 21
Cancers, Vol 13, Iss 5577, p 5577 (2021)
Volume 13
Issue 21
Simple Summary GD2 is an antigen that is tumor-specific and can be used as a target for specific immunotherapies. Since the knowledge about GD2 in breast cancer is limited, we analyzed the frequency of GD2 expression in breast cancer using two differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b718863f0ef5d71ee1fc4508f57dccb
https://doi.org/10.3390/cancers13215577
https://doi.org/10.3390/cancers13215577
Autor:
Holger N. Lode, Nikolai Siebert, Claudia Rossig, Kornelius Kerl, Ingo Müller, Claudia Göttlich, Stefanie Lesch, Bianca Altvater, Maike Fluegge, Wolfgang Hartmann, Sonja Schelhaas, Silke Jamitzky, Sebastian T. Balbach, Lea Greune, Heike Walles, Johanna Kühnemundt, Jutta Meltzer, Sareetha Kailayangiri, Jan-Henrik Mikesch, Nicole Farwick
Publikováno v:
Mol Ther
Chimeric antigen receptor (CAR) engineering of T cells allows one to specifically target tumor cells via cell surface antigens. A candidate target in Ewing sarcoma is the ganglioside G(D2), but heterogeneic expression limits its value. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c54360ba8e25b4d1bfedff824acf87
https://europepmc.org/articles/PMC6520468/
https://europepmc.org/articles/PMC6520468/
Autor:
Jutta Meltzer, Silke Jamitzky, Bianca Altvater, Katja Urban, Claudia Rossig, Nicole Farwick, Sareetha Kailayangiri, Lea Greune
Publikováno v:
Cancer Research. 80:4999-4999
Preclinical in vivo studies of chimeric antigen receptor (CAR) T cells often rely on NOD-scid gamma (NSG) mouse models which lack T cells, B cells and NK cells and thereby allow for reliable engraftment of human tumor xenografts. But murine myeloid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de53f4dafcac0fd1e039aeed109fa09
https://doi.org/10.1158/1538-7445.am2020-4999
https://doi.org/10.1158/1538-7445.am2020-4999
Autor:
Claudia Rossig, Heribert Juergens, Sareetha Kailayangiri, Ilka Neumann, Nadine Theimann, Martina Ahlmann, Anna Hansmeier, Bianca Altvater, Jendrik Hardes, Nicole Farwick, Sibylle Pscherer, Georg Gosheger, Gabriele Mrachatz, Christiane Chen
Publikováno v:
Cancer Immunology, Immunotherapy. 63:1047-1060
Disseminated or relapsed Ewing sarcoma (EwS) has remained fatal in the majority of patients. A promising approach to preventing relapse after conventional therapy is to establish tumor antigen-specific immune control. Efficient and specific T cell me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423961f1921349da2588951c028e6723
https://doi.org/10.1007/s00262-014-1574-3
https://doi.org/10.1007/s00262-014-1574-3
Autor:
Claudia Rossig, Eva Wardelmann, Jendrik Hardes, Schaefers Michael, Jan-Henrik Mikesch, Wolfgang Hartmann, Petra Fischer, Bianca Altvater, Silke Jamitzky, Stefanie Lesch, Nicole Farwick, Sareetha Kailayangiri, Jutta Meltzer, Sonja Schelhaas
Publikováno v:
Cancer Research. 78:4631-4631
Safe and effective targeting of cancer with chimeric antigen receptor (CAR) engineered T cells relies on the presence of adequate tumor-associated surface antigens. We have found that Ewing sarcomas (EwS) express ganglioside GD2 and are recognized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a710a9d2eb9d8e30b9aa51292cf0c091
https://doi.org/10.1158/1538-7445.am2018-4631
https://doi.org/10.1158/1538-7445.am2018-4631
Autor:
Birigit Lechtape, Martin Hasselblatt, Jörg Mühlisch, Steven C. Clifford, Michael C. Frühwald, Sabrina Schlosser, Joachim Gerss, Jonas H. Kreth, Gunther Richter, Rebekka Unland, Kornelius Kerl, Tanja Plagemann, Nicole Farwick
Publikováno v:
Journal of neuro-oncology. 116(2)
Epigenetic alterations are common events in cancer. Using a genome wide methylation screen (Restriction Landmark Genomic Scanning-RLGS) we identified the gene for the dopamine receptor D4 (DRD4) as tumor-specific methylated. As DRD4 is involved in ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89941e8fcd59bfdeff90fcdc75cbfc0
https://pubmed.ncbi.nlm.nih.gov/24264533
https://pubmed.ncbi.nlm.nih.gov/24264533