Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicole E. Baryla"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 52:316-319
During development of the residual solvent method using headspace-GC for a drug substance, an unexpected peak was observed in the chromatography. GC–MS analysis confirmed the unknown peak identity as isobutylene. An understanding of the source of t
Autor:
Catherine A. O’Brien, Mark J. Sinnamon, Eric S. Martin, Nicole E. Baryla, Ping Jiang, Kenneth E. Hung, Julie L.C. Kan, Scott L. Weinrich, Bradly G. Wouters, Oivin Guicherit, Valeria Fantin, David Shields, Peter Olson, Trevor D. McKee, Nathan V. Lee, James G. Christensen, Tao Xie, Paul A. Rejto, Jatin Roper, Jason Isaacson, Todd VanArsdale, Peter J. Belmont
Publikováno v:
Science signaling. 7(351)
Targeted blockade of aberrantly activated signaling pathways is an attractive therapeutic strategy for solid tumors, but drug resistance is common. KRAS is a frequently mutated gene in human cancer but remains a challenging clinical target. Inhibitor
Publikováno v:
Analytical Chemistry. 74:776-783
The double-chained, zwitterionic phospholipid 1,2-dilauroyl-sn-phosphatidylcholine (DLPC, C12) was investigated for its use as a wall coating for the prevention of protein adsorption in capillary electrophoresis. DLPC forms a semipermanent coating at
Publikováno v:
Analytical Chemistry. 73:4558-4565
This paper describes the adsorption mechanisms and aggregation properties of cetyltrimethylammonium bromide (CTAB) and didodecyldimethylammonium bromide (DDAB) surfactants that are used for dynamic coatings in capillary electrophoresis (CE). Atomic f
Publikováno v:
TrAC Trends in Analytical Chemistry. 20:365-374
Control of the electroosmotic flow (EOF) is critical for achieving optimal separations by capillary electrophoresis. For instance, manipulation of the EOF can yield either high resolution separations or rapid analyses. Dynamic capillary coatings are
Autor:
Nicole E. Baryla, Charles A. Lucy
Publikováno v:
ELECTROPHORESIS. 22:52-58
In capillary electrophoresis, the short optical path length associated with on-column UV detection imposes an inherent detection problem. Detection limits can be improved using sample stacking. Recently, large-volume sample stacking (LVSS) without po
Autor:
Chris M. Denis, Nicole E. Baryla
Publikováno v:
Journal of chromatography. A. 1110(1-2)
A fast, selective capillary electrophoresis (CE) method was developed for piperazine counter-ion analysis and applied to the analysis of an active pharmaceutical ingredient (API) that exists as a hemipiperazine salt. Due to the poor chromophore, the
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 276
Surfactants such as didodecyldimethyl ammonium bromide (DDAB) and 1,2-dilauroyl-sn-phosphatidylcholine (DLPC) form bilayers at the walls of bare silica capillaries. Once formed, these bilayers are stable in the absence of surfactant in the buffer. DD
Surfactants such as didodecyldimethyl ammonium bromide (DDAB) and 1,2-dilauroyl-sn-phosphatidylcholine (DLPC) form bilayers at the walls of bare silica capillaries. Once formed, these bilayers are stable in the absence of surfactant in the buffer. DD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f31b39ac5c5f5d81b104fd7f7677d6
https://doi.org/10.1385/1-59259-798-x:001
https://doi.org/10.1385/1-59259-798-x:001
Autor:
Nicole E. Baryla
Publikováno v:
Analytical Method Validation and Instrument Performance Verification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c691b584ce88db18073a5c02ec603e
https://doi.org/10.1002/0471463728.ch12
https://doi.org/10.1002/0471463728.ch12