Výsledky vyhledávání - "Nicole E. Ballard"

Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis

Autor: Angela E. Hawley, Diana M. Farris, Daniel D. Myers, Peter K. Henke, Daniel A. Lawrence, Nicole E Ballard-Lipka, Jose A. Diaz, Shirley K. Wrobleski, Thomas W. Wakefield

Publikováno v: Journal of Vascular Surgery. 55(3):815-822

BackgroundHyperlipidemia increases the level of blood plasminogen activator inhibitor-1 (PAI-1) that is responsible for regulating fibrinolysis by inhibiting both urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d14195ba5affa503f59d3bd44fbbb77

Zobrazit plný text záznamu

Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis

Autor: Thomas W. Wakefield, Shirley K. Wrobleski, Diana M. Farris, Nicole E. Ballard, Peter K. Henke, Angela E. Hawley, Eduardo Ramacciotti, Daniel D. Myers

Publikováno v: Thrombosis and Haemostasis. 101:748-754

SummaryMicroparticles (MP) are lipid vesicles from platelets, leukocytes and endothelial cells that are involved in early thrombogenesis. We evaluated a detailed time-course analysis of MPs on thrombogenesis and the associated tissue factor (TF) acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e99720e43cf5a05fff53f209b1d4e20c
https://doi.org/10.1160/th08-09-0620

Zobrazit plný text záznamu

Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation

Autor: Frank J. Londy, Shirley K. Wrobleski, Neelu Kaila, Paul J. Zajkowski, Patricia W. Bedard, Nicole E. Ballard, Daniel D. Myers, George P. Vlasuk, Robert G. Schaub, Angela E. Hawley, Thomas R. Meier, Thomas W. Wakefield

Publikováno v: Thrombosis and Haemostasis. 99:343-351

SummaryP-selectin inhibition has been evaluated as a therapeutic for prevention and treatment of venous thrombosis. In this study, a novel oral small-molecule inhibitor of P-selectin, PSI-421, was evaluated in a baboon model of stasis induced deep ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291955eaf2d3703645f84049fe6aa265
https://doi.org/10.1160/th07-10-0608

Zobrazit plný text záznamu

Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation

Autor: Frank J. Londy, Thomas R. Meier, S. Rohrer, Neelu Kaila, George D. Shaw, Chris Longo, Diana M. Farris, Paul J. Zajkowski, Daniel D. Myers, Thomas W. Wakefield, Shirley K. Wrobleski, Robert G. Schaub, Angela E. Hawley, Peter K. Henke, Nicole E. Ballard, Patricia W. Bedard, Beverly A. Fex

Publikováno v: Thrombosis and Haemostasis. 97:400-407

SummaryP-selectin inhibition has been shown to decrease thrombogenesis in multiple animal species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI-697, promotes thrombus resolution and decreases inflammation in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a3e6ba39d7b40804fa6327fa7ff2270
https://doi.org/10.1160/th06-11-0658

Zobrazit plný text záznamu

Abstract 24: Resolvin D2 Reduces Thrombus Burden and Attenuates Inflammatory Signaling Pathways in a Murine Model of Venous Thrombosis

Autor: Jose A Diaz, Maxim E Shaydakov, Anuran Chatterjee, Diana M Farris, Nicole E Ballard-Lipka, Angela E Hawley, Robert E Sigler, Peter K Henke, Daniel D Myers, Thomas W Wakefield, Michael S Conte

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35

Background: Specialized pro-resolving lipid mediators (SPM) derived from polyunsaturated fatty acids, such as Resolvin D2 (RvD2), play a critical role in the resolution of acute inflammation. In recent years, total organic synthesis of SPM have enabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73eb88101025ce2d91e6fc90aca8011c
https://doi.org/10.1161/atvb.35.suppl_1.24

Zobrazit plný text záznamu

Early Increased MT1-MMP Expression and Late MMP-2 and MMP-9 Activity during Angiotensin II Induced Aneurysm Formation

Autor: James C. Stanley, Erin Lynch, Sunita D. Srivastava, Nicole E. Ballard, Gilbert R. Upchurch, Matthew J. Eagleton

Publikováno v: Journal of Surgical Research. 135:345-351

Angiotensin II (Ang II) is associated with a variety of cardiovascular diseases including aneurysm formation. The aim of this study was to evaluate the temporal changes in MT1-matrix metalloproteinase (MMP) and MMP-2 and -9 expression and activity du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f8491636a2b87f4daafb8e2b3de4c
https://doi.org/10.1016/j.jss.2006.03.026

Zobrazit plný text záznamu

Allelic Loss and Tumor Pathology in Head and Neck Squamous Cell Carcinoma

Autor: Benjamin A. Rybicki, Daniel L. Van Dyke, Sonal C Patel, Adnan T. Savera, Michael S. Benninger, Jose A Gomez, Richard J. Zarbo, Nicole E Ballard

Publikováno v: Modern Pathology. 16:970-979

Allelic loss is a common occurrence in head and neck tumors and has been shown to be an independent predictor of prognosis; however, the relationship between allelic loss and tumor pathology is not well-known. We studied 139 patients who were newly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0ae0374d974ca2e70e54a17cbbd124
https://doi.org/10.1097/01.mp.0000086627.74271.13

Zobrazit plný text záznamu

Abstract 196: Matrix Metalloproteinases Regulation in Thrombus Resolution Is Independent of TGF-β in a PAI-1 Ko Mouse Model of Venous Thrombosis

Autor: Andrea T Obi, Thomas W Wakefield, Nicole E Ballard-Lipka, Diana M Farris, Daniel D Myers, Peter K Henke, Jose A Diaz

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 32

Introduction: Plasminogen activator inhibitor (PAI-1) is the primary regulator of urokinase (u-PA) and tissue (t-PA) plasminogen activators. Observations in mice with impaired fibrinolysis have demonstrated an alternate pathway of thrombus resolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d4e141cb39a19d21a0c6494353cbcf0
https://doi.org/10.1161/atvb.32.suppl_1.a196

Zobrazit plný text záznamu

Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation

Autor: Daniel D, Myers, Shirley K, Wrobleski, Chris, Longo, Patricia W, Bedard, Neelu, Kaila, George D, Shaw, Frank J, Londy, Suzan E, Rohrer, Beverly A, Fex, Paul J, Zajkowski, Thomas R, Meier, Angela E, Hawley, Diana M, Farris, Nicole E, Ballard, Peter K, Henke, Robert G, Schaub, Thomas W, Wakefield

Publikováno v: Thrombosis and haemostasis. 97(3)

P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI-697, promotes thrombus resolution and decreases inflammation in a baboon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5348ea3f4bc70d1e79108769f8fab17
https://pubmed.ncbi.nlm.nih.gov/17334507

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání