Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nicole E, Scharping"'
Autor:
Paolo D. A. Vignali, Kristin DePeaux, McLane J. Watson, Chenxian Ye, B. Rhodes Ford, Konstantinos Lontos, Nicole K. McGaa, Nicole E. Scharping, Ashley V. Menk, Simon C. Robson, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe
Publikováno v:
Nature Immunology. 24:267-279
Autor:
Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1509-1521 (2018)
Summary: To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events
Externí odkaz:
https://doaj.org/article/9a323dcf2c784882a7635f4587454ea7
Autor:
Saumendra N. Sarkar, Greg M. Delgoffe, Christopher J. Bakkenist, Hassane M. Zarour, Veit Hornung, Stephen H. Thorne, Pooja Karukonda, Joe-Marc Chauvin, Yiyang Wang, Ashley V. Menk, Chandra Nath Roy, Rashmi Srivastava, Frank P. Vendetti, Nicole E. Scharping, Weizhou Hou, Lulu Shao
Multiple studies have associated the transcription factor IRF1 with tumor-suppressive activities. Here, we report an opposite tumor cell–intrinsic function of IRF1 in promoting tumor growth. IRF1-deficient tumor cells showed reduced tumor growth in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a56b6cc559cb7e26d9a33e1e0d6618a
https://doi.org/10.1158/2326-6066.c.6549892
https://doi.org/10.1158/2326-6066.c.6549892
Autor:
Saumendra N. Sarkar, Greg M. Delgoffe, Christopher J. Bakkenist, Hassane M. Zarour, Veit Hornung, Stephen H. Thorne, Pooja Karukonda, Joe-Marc Chauvin, Yiyang Wang, Ashley V. Menk, Chandra Nath Roy, Rashmi Srivastava, Frank P. Vendetti, Nicole E. Scharping, Weizhou Hou, Lulu Shao
Supplementary Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a707a925bb3118d4a3df3e9885566d1c
https://doi.org/10.1158/2326-6066.22542367
https://doi.org/10.1158/2326-6066.22542367
Autor:
Saumendra N. Sarkar, Greg M. Delgoffe, Christopher J. Bakkenist, Hassane M. Zarour, Veit Hornung, Stephen H. Thorne, Pooja Karukonda, Joe-Marc Chauvin, Yiyang Wang, Ashley V. Menk, Chandra Nath Roy, Rashmi Srivastava, Frank P. Vendetti, Nicole E. Scharping, Weizhou Hou, Lulu Shao
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d77854966602f0497b01ef55305dcd
https://doi.org/10.1158/2326-6066.22542358
https://doi.org/10.1158/2326-6066.22542358
Metformin has indirect effects on immunity in the tumor microenvironment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5925d750743efc3d220817619bad3f
https://doi.org/10.1158/2326-6066.22538459.v1
https://doi.org/10.1158/2326-6066.22538459.v1
Metformin in the drinking water enhances PD-1 therapy in B16 melanoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdd7e29c0d4adc3b03b31a46634147f
https://doi.org/10.1158/2326-6066.22538456
https://doi.org/10.1158/2326-6066.22538456
Supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a00f6c365a50cb15d869c64385fb9fa
https://doi.org/10.1158/2326-6066.22538453.v1
https://doi.org/10.1158/2326-6066.22538453.v1
Blockade of the coinhibitory checkpoint molecule PD-1 has emerged as an effective treatment for many cancers, resulting in remarkable responses. However, despite successes in the clinic, most patients do not respond to PD-1 blockade. Metabolic dysreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64e44cd1f86d1a014035076c2e0085a
https://doi.org/10.1158/2326-6066.c.6548786.v1
https://doi.org/10.1158/2326-6066.c.6548786.v1
Autor:
B. Rhodes Ford, Paolo D. A. Vignali, Natalie L. Rittenhouse, Nicole E. Scharping, Ronal Peralta, Konstantinos Lontos, Andrew T. Frisch, Greg M. Delgoffe, Amanda C. Poholek
Publikováno v:
Sci Immunol
Response rates to immunotherapy in solid tumors remain low due in part to the elevated prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced through persistent antigen and stress signaling. However, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b08924bb4f05a2d0d80de6a93062a38
https://europepmc.org/articles/PMC9851604/
https://europepmc.org/articles/PMC9851604/