Výsledky vyhledávání - "Nicole E, Schapiro"

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

Autor: Herbert J. Zeh, Michael T. Lotze, Jarrod T. Ellis, Daolin Tang, Gianmarino C. Gianfrate, Patricia Loughran, Nicole E. Schapiro, Lidiya Orlichenko, Brian A. Boone, Rui Kang, Aatur D. Singhi

Publikováno v: Cancer gene therapy

Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones and intracellular proteins into the extracellular space or circulation. NET formation is dependent on autophagy and is mediated by citrullination of histones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7bf78092a625252f5f46417aea7fc1
https://doi.org/10.1038/cgt.2015.21

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The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

Autor: B. Van Houten, Daolin Tang, Timothy R. Billiar, Herbert J. Zeh, Michael T. Lotze, Haichao Wang, Tara J. Loux, Rui Kang, Kristen M. Livesey, Nicole E. Schapiro

Publikováno v: Oncogene. 33:567-577

Tumor cells require increased adenosine triphosphate (ATP) to support anabolism and proliferation. The precise mechanisms regulating this process in tumor cells are unknown. Here, we show that the receptor for advanced glycation endproducts (RAGE) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdae05600c61e1dee49a00371d295d1
https://doi.org/10.1038/onc.2012.631

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The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia

Autor: Alyssa M. Krasinskas, Philip Vernon, Michael T. Lotze, Rui Kang, Herbert J. Zeh, Daolin Tang, Nicole E. Schapiro, Kristen M. Livesey, Tara J. Loux

Publikováno v: Proceedings of the National Academy of Sciences. 109:7031-7036

Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early metastasis, resistance to chemotherapy, and early mutation of the Kras oncogene. Here we show that the receptor for advanced glycation endproducts (RAGE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c80e2b645461432cfebb3be22a8ca7
https://doi.org/10.1073/pnas.1113865109

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The Receptor for Advanced Glycation End-Products (RAGE) Protects Pancreatic Tumor Cells Against Oxidative Injury

Autor: Michael T. Lotze, Rui Kang, Daolin Tang, Kristen M. Livesey, Nicole E. Schapiro, Herbert J. Zeh

Publikováno v: Antioxidants & Redox Signaling. 15:2175-2184

Reactive oxygen species, including hydrogen peroxide (H2O2), can cause toxicity and act as signaling molecules in various pathways regulating both cell survival and cell death. However, the sequence of events between the oxidative insult and cell dam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ff909bb0e55a758e35d3246466a82d
https://doi.org/10.1089/ars.2010.3378

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HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells

Autor: Xiaoyan Liang, Herbert J. Zeh, Nicole E. Schapiro, Daolin Tang, Kevin J. Tracey, Kristen M. Livesey, Chun-Wei Cheh, Andrew A. Amoscato, Robert J. Benschop, Louis J. Sparvero, Rui Kang, Michael T. Lotze

Publikováno v: Oncogene

The functional relationship and cross-regulation between autophagy and apoptosis is complex. In this study we show that the high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of the balance between autophagy and apoptosis. In ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8175b3264167f895d6fb57cbaf3ac33e
http://europepmc.org/articles/PMC2945431

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The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

Autor: Rui Kang, Angelika Bierhaus, Daolin Tang, Adam M. Farkas, Nicole E. Schapiro, Patricia Loughran, Kristen M. Livesey, Herbert J. Zeh, Michael T. Lotze

Publikováno v: Cell death and differentiation

Activation of the induced receptor for advanced glycation end products (RAGE) leads to initiation of NF-kappaB and MAP kinase signaling pathways, resulting in propagation and perpetuation of inflammation. RAGE-knockout animals are less susceptible to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427ae013faf2edb756e8c98dc270438d
https://doi.org/10.1038/cdd.2009.149

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Ethyl pyruvate administration inhibits hepatic tumor growth

Autor: Donna Beer-Stolz, Herbert J. Zeh, Andrew A. Amoscato, Nicole E. Schapiro, Antonio Romo de Vivar Chavez, Michael T. Lotze, Patricia Loughran, Michael E. de Vera, Stephen H. Thorne, Xiaoyan Liang

Publikováno v: Journal of Leukocyte Biology. 86:599-607

The first demonstration of ethyl pyruvate inhibition of liver tumor growth associated with induction of tumor apoptosis, diminished HMGB1 release, and decreased inflammation is reported. EP is a potent inhibitor of HMGB1 release that has significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4894d2740f2ec03537e1140ae4e18b
https://doi.org/10.1189/jlb.0908578

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The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells

Autor: Nicole E. Schapiro, Ravi Muthuswamy, Daolin Tang, Tara J. Loux, Herbert J. Zeh, Michael T. Lotze, Rui Kang, Pawel Kalinski, Philip Vernon

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(3)

Pancreatic ductal adenocarcinoma (PDA) has an aggressive natural history and is resistant to therapy. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor for many damage-associated molecular pattern molecules. RA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d5456a46e95b33aaffe2a48c9a3e1e
https://pubmed.ncbi.nlm.nih.gov/23269246

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Abstract B96: The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

Autor: Daolin Tang, Rui Kang, Michael T. Lotze, Herbert J. Zeh, Nicole E. Schapiro

Publikováno v: Tumor Biology.

Background and Aims: Recently altered cellular bioenergetics and inflammation have been added to the list of essential hallmarks of cancer. The precise mechanisms regulating these processes are not well characterized. We previously observed that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dd6181b027842f48ccb9caa486ec859
https://doi.org/10.1158/1538-7445.panca2012-b96

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Focal adhesion kinase signaling controls cyclic tensile strain enhanced collagen I-induced osteogenic differentiation of human mesenchymal stem cells

Autor: Donald F, Ward, William A, Williams, Nicole E, Schapiro, Genevieve L, Weber, Samuel R, Christy, Megan, Salt, Robert F, Klees, Adele, Boskey, George E, Plopper

Publikováno v: Molecularcellular biomechanics : MCB. 4(4)

Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9f757187c6ef175a1f569ae6d12e76b
https://pubmed.ncbi.nlm.nih.gov/18437915

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