Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nicole Dobbs"'
Autor:
Xintao Tu, Ting-Ting Chu, Devon Jeltema, Kennady Abbott, Kun Yang, Cong Xing, Jie Han, Nicole Dobbs, Nan Yan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microbial DNA is recognized by the cGAS-STING pathway, which leads to a type I interferon response. Here authors show that a basal flux of interferon activation could also be triggered by interference with STING trafficking from the Golgi apparatus t
Externí odkaz:
https://doaj.org/article/2f9d65377a264c70b9738aa78c4ec3c2
Autor:
Charles S. Fermaintt, Kanae Sano, Zhida Liu, Nozomi Ishii, Junichi Seino, Nicole Dobbs, Tadashi Suzuki, Yang-Xin Fu, Mark A. Lehrman, Ichiro Matsuo, Nan Yan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic a
Externí odkaz:
https://doaj.org/article/02aa3410ad05460ab0fc4008becd936e
Autor:
Vijay K. Gonugunta, Tomomi Sakai, Vladislav Pokatayev, Kun Yang, Jianjun Wu, Nicole Dobbs, Nan Yan
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3234-3242 (2017)
STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on and quickly turns off downstream signaling as it translocates from the ER to vesicles. How STING signaling is attenuated during trafficking remains poorly understoo
Externí odkaz:
https://doaj.org/article/6fb2ae1df4924b1f85f0c536b0840d36
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55984 (2013)
Mycoplasmas cause chronic respiratory diseases in animals and humans, and to date, development of vaccines have been problematic. Using a murine model of mycoplasma pneumonia, lymphocyte responses, specifically T cells, were shown to confer protectio
Externí odkaz:
https://doaj.org/article/c1dea3c9d19849498cf422e51475133d
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10739 (2010)
Mycoplasma lipoproteins are recognized by Toll-like receptors (TLR), but TLRs' role in responses to infection are unknown. Mycoplasma pulmonis is a naturally occurring respiratory pathogen in mice. In the current study, we used TLR-transfected HEK ce
Externí odkaz:
https://doaj.org/article/9138038b8915415ca5563ab41645a581
Publikováno v:
The Journal of Immunology. 199:3840-3848
HIV-1 evades immune detection by the cGAS-STING cytosolic DNA-sensing pathway during acute infection. STING is a critical mediator of type I IFN production, and STING agonists such as cGMP-AMP (cGAMP) and other cyclic dinucleotides elicit potent immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57a126ee5134fc3046ae996174667f4
https://doi.org/10.4049/jimmunol.1700972
https://doi.org/10.4049/jimmunol.1700972
Autor:
Vladislav Pokatayev, Tomomi Sakai, Nicole Dobbs, Vijay K. Gonugunta, Jianjun Wu, Nan Yan, Kun Yang
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3234-3242 (2017)
Summary STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on and quickly turns off downstream signaling as it translocates from the ER to vesicles. How STING signaling is attenuated during trafficking remains poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc096516a54b61118a910c01bd3af30
http://www.sciencedirect.com/science/article/pii/S2211124717317138
http://www.sciencedirect.com/science/article/pii/S2211124717317138
Autor:
Nicole Dobbs, Maria A. Calvaruso, Nan Yan, Guillermo Palchik, Aktar Ali, Vijay K. Gonugunta, Maroof Hasan, Ralph J. DeBerardinis
Publikováno v:
Proceedings of the National Academy of Sciences. 114:746-751
Three-prime repair exonuclease 1 knockout (Trex1-/-) mice suffer from systemic inflammation caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96388b62a4cd6a29a491be4d958752cf
https://doi.org/10.1073/pnas.1611113114
https://doi.org/10.1073/pnas.1611113114
Publikováno v:
Immunity. 53(1)
Summary Type I interferon (IFN) response is commonly recognized as the main signaling activity of STING. Here, we generate the Sting1S365A/S365A mutant mouse that precisely ablates IFN-dependent activities while preserving IFN-independent activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9df8223f4308e6d88b1cc3cd9c88e1
https://pubmed.ncbi.nlm.nih.gov/32668231
https://pubmed.ncbi.nlm.nih.gov/32668231
Autor:
Ichiro Matsuo, Nan Yan, Junichi Seino, Mark A. Lehrman, Kanae Sano, Nozomi Ishii, Zhida Liu, Charles S. Fermaintt, Tadashi Suzuki, Nicole Dobbs, Yang Xin Fu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2371b75168a74593b55ceb1cdd24452
https://doi.org/10.1038/s41467-019-10319-5
https://doi.org/10.1038/s41467-019-10319-5