Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicole D. Barth"'
Autor:
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to imm
Externí odkaz:
https://doaj.org/article/773a1c7cda434f51a8e1ac084abce313
Autor:
Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole D. Barth, Isaac Maksso, Marc Vendrell, Lutz Ackermann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatab
Externí odkaz:
https://doaj.org/article/93b52903be4747fead66811972b504c1
Autor:
Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield, Marc Vendrell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imag
Externí odkaz:
https://doaj.org/article/7e4b972f90a04057803fb05db7c472e8
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Programmed cell death (apoptosis) has an important role in the maintenance of tissue homeostasis as well as the progression and ultimate resolution of inflammation. During apoptosis, the cell undergoes morphological and biochemical changes [e.g., pho
Externí odkaz:
https://doaj.org/article/53504da5ef244400bed52301211528d6
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Apoptosis and subsequent phagocytic clearance of apoptotic cells is important for embryonic development, maintenance of tissues that require regular cellular renewal and innate immunity. The timely removal of apoptotic cells prevents progression to s
Externí odkaz:
https://doaj.org/article/b35dc250df3a482ca069bbc8835ef4f0
Autor:
Nicole D. Barth, Floris J. Van Dalen, Utsa Karmakar, Marco Bertolini, Lorena Mendive‐Tapia, Takanori Kitamura, Martijn Verdoes, Marc Vendrell
Publikováno v:
Angewandte Chemie. International Edition, 61, 41
Barth, N D, Van Dalen, F J, Karmakar, U, Bertolini, M, Mendive-Tapia, L, Kitamura, T, Verdoes, M & Vendrell, M 2022, ' Enzyme-Activatable Chemokine Conjugates for In Vivo Targeting of Tumor-Associated Macrophages ', Angewandte Chemie International Edition, vol. 61, no. 41, e202207508 . https://doi.org/10.1002/anie.202207508
Angewandte Chemie. International Edition, 61
Angewandte Chemie International Edition
Barth, N D, Van Dalen, F J, Karmakar, U, Bertolini, M, Mendive-Tapia, L, Kitamura, T, Verdoes, M & Vendrell, M 2022, ' Enzyme-Activatable Chemokine Conjugates for In Vivo Targeting of Tumor-Associated Macrophages ', Angewandte Chemie International Edition, vol. 61, no. 41, e202207508 . https://doi.org/10.1002/anie.202207508
Angewandte Chemie. International Edition, 61
Angewandte Chemie International Edition
Contains fulltext : 287053.pdf (Publisher’s version ) (Open Access) Increased levels of tumor-associated macrophages (TAMs) are indicators of poor prognosis in most cancers. Although antibodies and small molecules blocking the recruitment of macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3ec7d1ffab7bf3010140ecbdc981bb
Autor:
Gabriela B.P. Souza, Eufrânio N. da Silva Júnior, Richard J. Mellanby, Zhiming Cheng, Nicole D. Barth, Wagner O. Valença, Fabio de Moliner, Gleiston G. Dias, Jamie I. Scott, Marc Vendrell
Publikováno v:
Cheng, Z, Valenca, W O, Dias, G G, Scott, J, Barth, N D, De Moliner, F, Souza, G B P, Mellanby, R, da Silva Junior, E N & Vendrell Escobar, M 2019, ' Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2019.07.017
Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cb7cc73c8773f6521093436aa60d5c
https://doi.org/10.1016/j.bmc.2019.07.017
https://doi.org/10.1016/j.bmc.2019.07.017
Autor:
Nikolaos, Kaplaneris, Jongwoo, Son, Lorena, Mendive-Tapia, Adelina, Kopp, Nicole D, Barth, Isaac, Maksso, Marc, Vendrell, Lutz, Ackermann
Publikováno v:
Nature Communications
Bioorthogonal late-stage diversification of amino acids and peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies largely rely on traditional, lengthy prefunctionalization methods,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5db99aa027f611d66d4012373908013
https://pubmed.ncbi.nlm.nih.gov/34099672
https://pubmed.ncbi.nlm.nih.gov/34099672
Autor:
Félix M. Goñi, Ian Dransfield, Adriano G. Rossi, Sónia Troeira Henriques, Nicole D. Barth, Rodolfo Lavilla, Sonja Vermeren, Lorena Mendive-Tapia, Mikala Egeblad, Mario A. Shields, John A. Marwick, Ramon Subiros-Funosas, Jesús Sot, Marc Vendrell, Jennifer A Cartwright, Rodger Duffin
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Barth, N D, Subiros-Funosas, R, Mendive-Tapia, L, Duffin, R, Shields, M A, Cartwright, J A, Henriques, S T, Sot, J, Goñi, F M, Lavilla, R, Marwick, J A, Vermeren, S, Rossi, A G, Egeblad, M, Dransfield, I & Vendrell, M 2020, ' A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis ', Nature Communications, vol. 11, 4027 . https://doi.org/10.1038/s41467-020-17772-7
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
Nature Communications
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
instname
Universidad de Barcelona
Barth, N D, Subiros-Funosas, R, Mendive-Tapia, L, Duffin, R, Shields, M A, Cartwright, J A, Henriques, S T, Sot, J, Goñi, F M, Lavilla, R, Marwick, J A, Vermeren, S, Rossi, A G, Egeblad, M, Dransfield, I & Vendrell, M 2020, ' A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis ', Nature Communications, vol. 11, 4027 . https://doi.org/10.1038/s41467-020-17772-7
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
Nature Communications
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
instname
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered by the need for fixatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a0303764e7028e12b02b2c1a6a1954
http://hdl.handle.net/2445/174241
http://hdl.handle.net/2445/174241
Autor:
Ramon Subiros-Funosas, Ouldouz Ghashghaei, Xavier Barril, Morena Pappalardo, Marc Vendrell, Bin-Zhi Qian, Lorena Mendive-Tapia, Ruoyu Ma, Rodolfo Lavilla, Cheng-Bin Zhang, Nicole D. Barth, Miquel Sintes, Vivian Cheuk Lam Ho
Publikováno v:
Chemical Science
Dipòsit Digital de la UB
Universidad de Barcelona
Subiros-funosas, R, Ho, V C L, Barth, N D, Mendive-tapia, L, Pappalardo, M, Barril, X, Ma, R, Zhang, C, Qian, B, Sintes, M, Ghashghaei, O, Lavilla, R & Vendrell, M 2019, ' Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas ', Chemical Science, vol. 11, no. 5, pp. 1368-1374 . https://doi.org/10.1039/C9SC05558D
Dipòsit Digital de la UB
Universidad de Barcelona
Subiros-funosas, R, Ho, V C L, Barth, N D, Mendive-tapia, L, Pappalardo, M, Barril, X, Ma, R, Zhang, C, Qian, B, Sintes, M, Ghashghaei, O, Lavilla, R & Vendrell, M 2019, ' Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas ', Chemical Science, vol. 11, no. 5, pp. 1368-1374 . https://doi.org/10.1039/C9SC05558D
Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba57cee79c8d7531c6a24419dbc315c