Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nicole Coolen-van Neer"'
Autor:
Hennie R. Hoogenboom, Edward H. Cohen, Shannon Hogan, Isaac J. Rondon, Malini Viswanathan, Jennifer A. Leeds, Robert Charles Ladner, Andrew E. Nixon, Marc Daukandt, Rachel Baribault Kent, Sonia Schoonbroodt, Nicole Coolen-van Neer, Nastri Horacio G, Guannan Kuang, Daniel J. Sexton, Lili Huang, Kristin L. Rookey, Louise Rem, Irina Kashin, Rob van Hegelsom, Mieke Steukers, Simon E. Hufton, Mary Devlin, Henk Pieters, Nicolas Frans, Rene Hoet
Publikováno v:
Nature Biotechnology. 23:344-348
Combinatorial libraries of rearranged hypervariable V(H) and V(L) sequences from nonimmunized human donors contain antigen specificities, including anti-self reactivities, created by random pairing of V(H)s and V(L)s. Somatic hypermutation of immunog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ee38e2a6e16eb22f970e86cc5aa60a
https://doi.org/10.1038/nbt1067
https://doi.org/10.1038/nbt1067
Autor:
Nicole Coolen-van Neer, Jürgen Müllberg, Hennie R. Hoogenboom, Paula Henderikx, Edith van der Linden, Anita Jacobs, Jan-Willem Arends
We describe the engineering and characterization of a whole human antibody directed toward the tumor-associated protein core of human MUC1. The antibody PH1 originated from the in vitro selection on MUC1 of a nonimmune human Fab phage library. The PH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ebf4874264713acbb85a4aaf2fcf8
https://europepmc.org/articles/PMC1850867/
https://europepmc.org/articles/PMC1850867/
Autor:
Hennie R. Hoogenboom, Twan van den Beuken, Johan Desmet, Erwin Sablon, Nicole Coolen van Neer, Simon E. Hufton
Publikováno v:
FEBS letters. 475(3)
We have explored the possibilities of using human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) as a single immunoglobulin fold-based scaffold for the generation of novel binding ligands. To obtain a suitable protein library selection system,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2972e39be24f57e61d7578826a9e7fba
https://pubmed.ncbi.nlm.nih.gov/10869561
https://pubmed.ncbi.nlm.nih.gov/10869561